Protein Alignment IleRS-m and ISM1

DIOPT Version :10

• Sequence 1: NP_648837.2
• Gene: IleRS-m / 39762
• FlyBaseID: FBgn0036569
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_015285.1
• Gene: ISM1 / 856067
• SGDID: S000005961
• Length: 1002
• Species: Saccharomyces cerevisiae
• Alignment Length: 1031
• Identity: 353/1031 - (34%)
• Similarity: 543/1031 - (52%)
• Gaps: 143/1031 - (13%)

  Fly     7 FRVGNRLYSMKAAKKDAKKYTDTINLPKTKFPNR--LTAAKRE---EQERLVLENKIAVSYA--- 63
            |.:.::.|..|.|      |..|:||||||||||  |....||   :..:||.:.::...:.
Yeast    12 FSIISKRYLAKHA------YQKTLNLPKTKFPNRSNLEITLRELIPKSSQLVYKEQLRDFFEEFS 70

  Fly    64 ---YQEQRLAEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHG 125
               ..:::|....:..|:||||||||||:||:|||:|||||||..|.:::.|:.:.|.|||||||
Yeast    71 KLNTTDEKLEFIKEKLFILHDGPPYANGELHLGHALNKILKDIINRYQLSQGKYIFYKPGWDCHG 135

  Fly   126 LPIELKATSTAPGQ-----SAQEIRQKSRAFAWEAIKSQKEEFSSWGILANWQKDNIYMTFQPEF 185
            ||||:||......|     |..:||..:...|.:|||.|:|.|..:.||.:|:..  |:|...::
Yeast   136 LPIEIKALKDLSAQQIESISPLKIRSMALKHAQKAIKRQRETFQHFAILTDWETP--YLTMDKDY 198

  Fly   186 IVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAELEYDANHISPSVYVRFAL-NPSSFDVK 249
            .:|||.:|..:||:||:.|..|||||...:||||||.||||:.||.|.:.||:|.| ..|..|:.
Yeast   199 EINQLNIFKEMYERGLIKRQNKPVYWGTETRTALAEGELEYNENHKSIAAYVKFPLEKKSQMDLC 263

  Fly   250 DK-------QIYALVWTTTPWTLPSNQAICYNASLEYVIVRLSDRNQDELYLMASALMADFEANT 307
            .|       .||.|:||:|||||.||:|||:|....|.::||:    .||.|:.:..:......|
Yeast   264 KKLGITNNLPIYCLIWTSTPWTLLSNRAICFNQDFSYSLLRLN----SELILVETGSIDKLGLTT 324

  Fly   308 QLKCEIVQHLSGELLSKLSYNHPIDKEQSNLPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQ 372
            . ..|.::...|..|:.|.|.:.:..::...|....:||....|||||||||.||.:|:|:.:..
Yeast   325 N-SFETIKQFQGTHLNGLYYQNLLVDDKVGRPLLHGAHVTSGTGTGLVHTAPGHGQDDYLIGIQN 388

  Fly   373 KIPVKCFVNEEGTY------------TKEAPDFLRGKSVLD-QGNSLVLDRIAE-DVVHSS-KLE 422
            .:.:...|:.:|.|            .::..|..:|:.||| :...::|.:::: ::::.| :..
Yeast   389 GLEIYSPVDHQGRYQLNELPQSVRSIVRDEGDLTKGRQVLDAETAKIILCKLSDLNLLYKSHEYT 453

  Fly   423 HSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPRANAEASKKALLTQLQKRPYWC 487
            ||||.|||:||||||||:.|||.:...:|..|.:::.:|:..|:    .....|.:.::.|..||
Yeast   454 HSYPYDWRSKKPVIIRATPQWFADLHDVKNLALESISRVKFCPK----RGYSRLSSFMKSRNEWC 514

  Fly   488 ISRQRAWGVPIPVLYSR-ESGKVVLNSALIEHLCNLLRKEGSIDFWW---VKSVEELVPEHLLRE 548
            |||||:||:||...|.: |...|::||.::.|....::::| |:.|:   ...::|.:||    :
Yeast   515 ISRQRSWGIPILSFYKKSEPDSVLMNSEILAHAIEKIKQKG-INAWFNDKDNDMKEWLPE----K 574

  Fly   549 LHHEAKDLVKGTDILDIWFDSGSTWSAVLGKD------KIADL-------YLEGYDQFTGWFQSS 600
            .|..|.:..:..|.:|:||||||:||.:  ||      |::.|       .|||.||..||||||
Yeast   575 YHDVAHEYCRSQDTMDVWFDSGSSWSVI--KDFYEKSLKLSKLPSPLYQVCLEGSDQHRGWFQSS 637

  Fly   601 LLMSIAARE--CAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITK--------KYGTDALRWW 655
            ||..:|:..  .|||:.:..||||:||.|.|||||:||.|||:.|.:        ..|.|.||:.
Yeast   638 LLTKVASSNVPVAPYEEVITHGFTLDENGLKMSKSVGNTISPEAIIRGDENLGLPALGVDGLRYL 702

  Fly   656 VA-SHGTQHMSITVSDKLLQQAAENLCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSYLNRYLLSQ 719
            :| |:.|  ..|.....:::...|.|.|:|.|.|||...: :|.....|:.......:::|.|.:
Yeast   703 IAQSNFT--TDIVAGPTVMKHVGEALKKVRLTFRYLLSNL-QKSQDFNLLPIEQLRRVDQYTLYK 764

  Fly   720 LVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYCGDDHELLAIRQ---TLTHC 781
            :.|......:.||.|.:::|:..:|..:.|::||.|..:.||.|| .:....||.||   ||.|.
Yeast   765 INELLETTREHYQKYNFSKVLITLQYHLNNELSAFYFDISKDILY-SNQISSLARRQVQTTLVHI 828

  Fly   782 YQQLCKSLWPIVPFLVEESWSYYDTTGGAFHEQIVQTNP---EWQ--DTKATEVINA--AFDVKR 839
            .......|.||:|.:|:|.|.|. ..|....::.:..||   :|.  |:. ||::.:  .|::|.
Yeast   829 LNAYRAILAPILPVMVQEVWKYI-PEGWLQGQEHIDINPMRGKWPFLDSN-TEIVTSFENFELKI 891

  Fly   840 L---------INQQAGDVNTWHLAVTIKGKERSQLDLLRELHSPLGESVSNSELCEILQVGSVTL 895
            |         ::.:.|...|.|..|||..|.          |.|.    |:.|||:|||..:|.:
Yeast   892 LKQFQEEFKRLSLEEGVTKTTHSHVTIFTKH----------HLPF----SSDELCDILQSSAVDI 942

  Fly   896 LQ---SHNS----------DLDIALSKLQISLCPRCRRYGLEDEQKTCQRCSDVME 938
            ||   ::||          ::.|.:.:.:...||||.:....:|.|.|.||.:.::
Yeast   943 LQMDDNNNSLPTIELGSGINVQILVERSKRHNCPRCWKANSAEEDKLCDRCKEAVD 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IleRS-m	NP_648837.2	IleS	26..936	CDD:439830	349/1008 (35%)
ISM1	NP_015285.1	ileS	35..920	CDD:273054	317/908 (35%)