DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IleRS-m and OVA2

DIOPT Version :9

Sequence 1:	NP_648837.2	Gene:	IleRS-m / 39762	FlyBaseID:	FBgn0036569	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001190497.1	Gene:	OVA2 / 834962	AraportID:	AT5G49030	Length:	1279	Species:	Arabidopsis thaliana

Alignment Length:	1036	Identity:	369/1036 - (35%)
Similarity:	540/1036 - (52%)	Gaps:	157/1036 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AAKKDAK-------KYTDTINLPKTKFPNRLTAAKRE-EQERLVLENKIAVSYAYQEQRLAEKGK 74
            ||||.::       ||..|::||||.|..|..:..|| |.::|..||::.       :|:::...
plant   273 AAKKASEGEKQEDGKYKQTVDLPKTGFGMRANSLTREPELQKLWEENQVF-------KRVSDNNN 330

  Fly    75 -PTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATSTAPG 138
             .:|:||||||||||.||||||:|||||||..|.::....:|.|:|||||||||||||...:...
plant   331 GGSFILHDGPPYANGDLHMGHALNKILKDIINRYKLLQNYKVQYVPGWDCHGLPIELKVLQSLDQ 395

  Fly   139 QSAQE-----IRQKSRAFAWEAIKSQKEEFSSWGILANWQKDNIYMTFQPEFIVNQLEMFYNLYE 198
            :..:|     :|.|:..||...:|:|.|.|..:|:.|:|  :|.|:|..||:...|:|:|..:..
plant   396 EVRKELTPLKLRAKAAKFAKATVKTQMESFKRFGVWADW--NNPYLTLDPEYEAAQIEVFGQMAL 458

  Fly   199 KGLVYRDLKPVYWSPSSRTALAEAELEYDANHISPSVYVRFAL----NPSSFDVKDKQIYALVWT 259
            ||.:||..|||:||||||||||||||||...|||.|:|..|.|    ..|..|.....||..|||
plant   459 KGYIYRGRKPVHWSPSSRTALAEAELEYPEGHISKSIYAIFKLVGGAKTSLLDEFIPNIYLAVWT 523

  Fly   260 TTPWTLPSNQAICYNASLEYVIVRLSD--------------------RNQDELY-LMASALMADF 303
            |||||:|:|.|:..||.|:|.:|.:..                    :||.:|: ::|:.|:...
plant   524 TTPWTMPANAAVAVNAKLQYSVVEVQSFSEDESTVTSNKKKIPGKVLKNQQKLFVIVATDLVPAL 588

  Fly   304 EANTQLKCEIVQHLSGELLSKLSYNHPIDKEQSNLPFFDASHVQDSKGTGLVHTAPAHGPEDFLV 368
            ||...:|..|.:...|..|....|.||||.....: .....::....|||||||||.||.||:..
plant   589 EAKWGVKLSISKTFLGSDLENCRYTHPIDNRDCPV-VIGGDYITTESGTGLVHTAPGHGQEDYAT 652

  Fly   369 SLTQKIPVKCFVNEEGTYTKEAPDFLRGKSVLDQGNSLVLDRIAED--VVHSSKLEHSYPIDWRT 431
            .|...:|:...|::||.:|:||..| ||.|||.:||:.|:..:.|:  :|......|.||.||||
plant   653 GLKYGLPLVSPVDDEGKFTEEAGQF-RGLSVLGEGNTAVVSYLDENMSLVMEESYAHKYPYDWRT 716

  Fly   432 KKPVIIRASEQWFINTEKLKTPAADALEQVEIYPRANAEASKKALLTQLQKRPYWCISRQRAWGV 496
            |||.|.||:||||.:.|..:|...||:..|:..|  :...::.:.:|  ..|..|||||||.|||
plant   717 KKPTIFRATEQWFASVEGFRTATMDAINNVKWVP--HQAVNRISAMT--SSRSDWCISRQRTWGV 777

  Fly   497 PIPVLYSRESGKVVLNSALIEHLCNLLRKEGSIDFWWVKSVEELVPEHLLRELHHEAKDLVKGTD 561
            |||..|..::.:.::|...|.|:.:::.::|| |.||..|||:|:||    :...:|.|..||||
plant   778 PIPAFYHVKTKEPLMNEETINHVKSIISQKGS-DAWWYMSVEDLLPE----KYRDKAADYEKGTD 837

  Fly   562 ILDIWFDSGSTWSAVLGKDK----IADLYLEGYDQFTGWFQSSLLMSIAARECAPYKALFVHGFT 622
            .:|:||||||:|:.||||.:    .||:||||.||..||||||||.|||.:..|||.|:..|||.
plant   838 TMDVWFDSGSSWAGVLGKREGLSFPADVYLEGTDQHRGWFQSSLLTSIATQGKAPYSAVITHGFV 902

  Fly   623 VDEKGYKMSKSLGNVISPKQITK---------KYGTDALRWWVAS---HGTQHMSITVSDKLLQQ 675
            :||||.|||||||||:.|:.:.:         .||.|.:|.||:|   .|    .:.:..::|:|
plant   903 LDEKGMKMSKSLGNVVDPRLVIEGGKNSKDAPAYGADVMRLWVSSVDYTG----DVLIGPQILRQ 963

  Fly   676 AAENLCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSYLNRYLLSQLVEFESEVEKLYQAYEYNRVV 740
            .::...|:|||:|||.|.:.:.:. :..:...|...::::.|.||......:::.|:.|::.::.
plant   964 MSDIYRKLRGTLRYLLGNLHDWRV-DNAVPYQDLPIIDQHALFQLENVVKNIQECYENYQFFKIF 1027

  Fly   741 ACVQNFIANQVSAVYVHLIKDRLYCGDDHELL--AIRQTLTHCYQQLCKSLWPIVPFLVEESWSY 803
            ..:|.|....:|..|..:.|||||.|......  :.:..|:.....:.:.:.||||.|.|:.|
plant  1028 QIIQRFTIVDLSNFYFDIAKDRLYTGGTSSFTRRSCQTVLSTHLLSILRVIAPIVPHLAEDVW-- 1090

  Fly   804 YDTTGGAFHEQIVQTNP-EW--QDTKATEVINAAFDVK-RLINQQ-----AGDVNTWHLAVTIKG 859
                         |..| |:  :|..|.|.:   |::| ..:|:|     |.||..|...:.::.
plant  1091 -------------QNLPFEYRNEDGSAAEFV---FELKWPTLNEQWLSFPAEDVLFWQRLLELRT 1139

  Fly   860 KERSQLDLLRE-------------LHS----------PLGESVSNSE-LCEILQVGSVTLLQSHN 900
            :....|:|.|.             ||:          .:.|:.:.:: |..|.....|.:|.|..
plant  1140 EVNKVLELARNEKMIGSSLEAKVYLHTADAGMAAKLLEMSEAKNEADTLQRIFITSQVEVLSSME 1204

  Fly   901 SDLD-----------------IALSKLQISLCPRCRRY-----GLEDEQKTCQRCSDVMEA 939
            .::.                 |.:|:.:.|.|.||..|     ...|....|.||..|:.|
plant  1205 KEMISSVQHTGEYVEGENKVWIGVSRAEGSKCERCWNYSGQVGSFSDHPTLCGRCFSVIVA 1265

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS-m	NP_648837.2	ileS	26..938	CDD:235588	363/1018 (36%)
		nt_trans	75..>211	CDD:294020	67/140 (48%)
		nt_trans	<434..658	CDD:294020	108/236 (46%)
		Anticodon_Ia_Ile_BEm	668..842	CDD:153414	42/179 (23%)
OVA2	NP_001190497.1	Dirigent	45..177	CDD:281071
		PLN02843	301..1275	CDD:215452	357/1008 (35%)
		nt_trans	333..>471	CDD:294020	67/139 (48%)
		tRNA-synt_1_2	<613..694	CDD:290334	34/82 (41%)
		IleRS_core	<719..956	CDD:173909	110/249 (44%)
		Anticodon_Ia_Ile_BEm	956..1142	CDD:153414	48/204 (24%)
		zf-FPG_IleRS	1233..1259	CDD:284292	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	503	1.000	Domainoid score	I71
eggNOG	1	0.900	-	-		E1_COG0060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7118
Inparanoid	1	1.050	570	1.000	Inparanoid score	I241
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D59501at2759
OrthoFinder	1	1.000	-	-		FOG0003995
OrthoInspector	1	1.000	-	-		oto3564
orthoMCL	1	0.900	-	-		OOG6_101646
Panther	1	1.100	-	-	LDO	PTHR42765
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2759
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840