DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IleRS-m and IARS2

DIOPT Version :9

Sequence 1:	NP_648837.2	Gene:	IleRS-m / 39762	FlyBaseID:	FBgn0036569	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_060530.3	Gene:	IARS2 / 55699	HGNCID:	29685	Length:	1012	Species:	Homo sapiens

Alignment Length:	983	Identity:	384/983 - (39%)
Similarity:	567/983 - (57%)	Gaps:	96/983 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KYTDTINLPKTKFPNRLTAAKREEQERLVLENKIAVS--YAYQEQRLAEKGKPTFVLHDGPPYAN 87
            :|.||:.||:|.||.:|...::.:.| |.::.|...|  |::|.:|   |.|..|.|||||||||
Human    59 RYRDTVLLPQTSFPMKLLGRQQPDTE-LEIQQKCGFSELYSWQRER---KVKTEFCLHDGPPYAN 119

  Fly    88 GQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATS----TAPGQSAQEIRQKS 148
            |..|:|||:|||||||..|..:.:|.:::::|||||||||||:|..|    .|...||.|||:|:
Human   120 GDPHVGHALNKILKDIANRFHMMNGSKIHFVPGWDCHGLPIEIKVLSELGREAQNLSAMEIRKKA 184

  Fly   149 RAFAWEAIKSQKEEFSSWGILANWQKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSP 213
            |:||..||:.||..|..|||:|:|  :|.|.||..::...||..||.:|:||||||..|||:|||
Human   185 RSFAKAAIEKQKSAFIRWGIMADW--NNCYYTFDGKYEAKQLRTFYQMYDKGLVYRSYKPVFWSP 247

  Fly   214 SSRTALAEAELEYDANHISPSVYVRFAL---NPSSFDVKD--KQIYALVWTTTPWTLPSNQAICY 273
            |||||||||||||:..|:|.|:||:|.|   :|....:.|  ..:..|||||.|||:|:|:|:||
Human   248 SSRTALAEAELEYNPEHVSRSIYVKFPLLKPSPKLASLIDGSSPVSILVWTTQPWTIPANEAVCY 312

  Fly   274 NASLEYVIVRLSDRNQDELYLMASALMADFEANTQLKCEIVQHLSGELLSKLSYNHPIDKEQSNL 338
            ....:|.:|:.|  ...:||::|:..:|...:..:...|.:..|||..|...:.:||:..::::
Human   313 MPESKYAVVKCS--KSGDLYVLAADKVASVASTLETTFETISTLSGVDLENGTCSHPLIPDKAS- 374

  Fly   339 PFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFLRGKSVLDQG 403
            |...|:||..:|||||||||||||.||:.|:....:|:.|.|:|:|.:|..|...|:.|:||::|
Human   375 PLLPANHVTMAKGTGLVHTAPAHGMEDYGVASQHNLPMDCLVDEDGVFTDVAGPELQNKAVLEEG 439

  Fly   404 NSLVLDRI--AEDVVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPR 466
            ..:|:..:  |::::...||.||||.||||||||:||||:|||||...:||.|.:.|::|:..|
Human   440 TDVVIKMLQTAKNLLKEEKLVHSYPYDWRTKKPVVIRASKQWFINITDIKTAAKELLKKVKFIP- 503

  Fly   467 ANAEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLNSALIEHLCNLLRKEGSIDF 531
               .::...::..:.:||||||||||.|||||||.:.:...:.::||...||:..|:.:.|| |.
Human   504 ---GSALNGMVEMMDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIVKLVEQHGS-DI 564

  Fly   532 WWVKSVEELVPEHLLREL-HHEAKDLVKGTDILDIWFDSGSTWSAVL-GKDKIADLYLEGYDQFT 594
            ||....|:|:|:.:|.|: ..:|.:.|.|.||||||||||::||.|| |.|:.|||||||.||..
Human   565 WWTLPPEQLLPKEVLSEVGGPDALEYVPGQDILDIWFDSGTSWSYVLPGPDQRADLYLEGKDQLG 629

  Fly   595 GWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITK---------KYGTD 650
            ||||||||.|:|||:.||||.:.|||||:.|||.||||||||||.|..:..         .||.|
Human   630 GWFQSSLLTSVAARKRAPYKTVIVHGFTLGEKGEKMSKSLGNVIHPDVVVNGGQDQSKEPPYGAD 694

  Fly   651 ALRWWVASHGTQHMSITVSDKLLQQAAENLCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSYLNRY 715
            .||||||.... ...:.:...:|..|.:::.|:|.|:|:|.|.:.:.......|..:|...:::|
Human   695 VLRWWVADSNV-FTEVAIGPSVLNAARDDISKLRNTLRFLLGNVADFNPETDSIPVNDMYVIDQY 758

  Fly   716 LLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYC--GDDHELLAIRQTL 778
            :|..|.:..:::.:||:.|::.:||..::.|...::|..|..:|||||||  .:|.:..:.:..|
Human   759 MLHLLQDLANKITELYKQYDFGKVVRLLRTFYTRELSNFYFSIIKDRLYCEKENDPKRRSCQTAL 823

  Fly   779 THCYQQLCKSLWPIVPFLVEESWS---YYDTTGGAFHEQIVQTNPEWQDTKATEVINAAFDVKRL 840
            ......:.:|..||:|.|.||.:.   |.......|....:.|:..|:.....|.:.:|..::
Human   824 VEILDVIVRSFAPILPHLAEEVFQHIPYIKEPKSVFRTGWISTSSIWKKPGLEEAVESACAMR-- 886

  Fly   841 INQQAGDVNTWHLAVTIKGKERSQ------------LDLLRELHSPLGESVSNSELCEILQVGSV 893
             :...|         :|.||..::            .:::..|.|.  |:.|.|:|.|::.....
Human   887 -DSFLG---------SIPGKNAAEYKVITVIEPGLLFEIIEMLQSE--ETSSTSQLNELMMASES 939

  Fly   894 TLL----QSHNSDLDIALSKLQISL----------------------CPRCRRYGLEDEQKTCQR 932
            |||    :...:|:.....|..|:|                      ||||.:|..|.....|.|
Human   940 TLLAQEPREMTADVIELKGKFLINLEGGDIREESSYKVIVMPTTKEKCPRCWKYTAESSDTLCPR 1004

  Fly   933 CSDVMEAK 940
            |::|:..|
Human  1005 CAEVVSGK 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS-m	NP_648837.2	ileS	26..938	CDD:235588	383/978 (39%)
		nt_trans	75..>211	CDD:294020	75/139 (54%)
		nt_trans	<434..658	CDD:294020	120/234 (51%)
		Anticodon_Ia_Ile_BEm	668..842	CDD:153414	43/178 (24%)
IARS2	NP_060530.3	ileS	60..1011	CDD:235588	383/979 (39%)
		nt_trans	107..>245	CDD:294020	75/139 (54%)
		'HIGH' region. /evidence=ECO:0000250	116..126		6/9 (67%)
		tRNA-synt_1_2	266..440	CDD:290334	66/176 (38%)
		IleRS_core	<472..708	CDD:173909	121/241 (50%)
		'KMSKS' region. /evidence=ECO:0000250	664..668		3/3 (100%)
		Anticodon_Ia_Ile_BEm	711..890	CDD:153414	43/181 (24%)
		zf-FPG_IleRS	985..1006	CDD:284292	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144309
Domainoid	1	1.000	576	1.000	Domainoid score	I219
eggNOG	1	0.900	-	-		E1_COG0060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7118
Inparanoid	1	1.050	683	1.000	Inparanoid score	I713
Isobase	1	0.950	-	0	Normalized mean entropy	S1385
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D101703at33208
OrthoFinder	1	1.000	-	-		FOG0003995
OrthoInspector	1	1.000	-	-		oto90792
orthoMCL	1	0.900	-	-		OOG6_101646
Panther	1	1.100	-	-	LDO	PTHR42765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2759
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.760