Protein Alignment IleRS-m and IARS2

DIOPT Version :10

• Sequence 1: NP_648837.2
• Gene: IleRS-m / 39762
• FlyBaseID: FBgn0036569
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_060530.3
• Gene: IARS2 / 55699
• HGNCID: 29685
• Length: 1012
• Species: Homo sapiens
• Alignment Length: 983
• Identity: 384/983 - (39%)
• Similarity: 567/983 - (57%)
• Gaps: 96/983 - (9%)

  Fly    25 KYTDTINLPKTKFPNRLTAAKREEQERLVLENKIAVS--YAYQEQRLAEKGKPTFVLHDGPPYAN 87
            :|.||:.||:|.||.:|...::.:.| |.::.|...|  |::|.:|   |.|..|.|||||||||
Human    59 RYRDTVLLPQTSFPMKLLGRQQPDTE-LEIQQKCGFSELYSWQRER---KVKTEFCLHDGPPYAN 119

  Fly    88 GQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKATS----TAPGQSAQEIRQKS 148
            |..|:|||:|||||||..|..:.:|.:::::|||||||||||:|..|    .|...||.|||:|:
Human   120 GDPHVGHALNKILKDIANRFHMMNGSKIHFVPGWDCHGLPIEIKVLSELGREAQNLSAMEIRKKA 184

  Fly   149 RAFAWEAIKSQKEEFSSWGILANWQKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSP 213
            |:||..||:.||..|..|||:|:|  :|.|.||..::...||..||.:|:||||||..|||:|||
Human   185 RSFAKAAIEKQKSAFIRWGIMADW--NNCYYTFDGKYEAKQLRTFYQMYDKGLVYRSYKPVFWSP 247

  Fly   214 SSRTALAEAELEYDANHISPSVYVRFAL---NPSSFDVKD--KQIYALVWTTTPWTLPSNQAICY 273
            |||||||||||||:..|:|.|:||:|.|   :|....:.|  ..:..|||||.|||:|:|:|:||
Human   248 SSRTALAEAELEYNPEHVSRSIYVKFPLLKPSPKLASLIDGSSPVSILVWTTQPWTIPANEAVCY 312

  Fly   274 NASLEYVIVRLSDRNQDELYLMASALMADFEANTQLKCEIVQHLSGELLSKLSYNHPIDKEQSNL 338
            ....:|.:|:.|  ...:||::|:..:|...:..:...|.:..|||..|...:.:||:..::::
Human   313 MPESKYAVVKCS--KSGDLYVLAADKVASVASTLETTFETISTLSGVDLENGTCSHPLIPDKAS- 374

  Fly   339 PFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFLRGKSVLDQG 403
            |...|:||..:|||||||||||||.||:.|:....:|:.|.|:|:|.:|..|...|:.|:||::|
Human   375 PLLPANHVTMAKGTGLVHTAPAHGMEDYGVASQHNLPMDCLVDEDGVFTDVAGPELQNKAVLEEG 439

  Fly   404 NSLVLDRI--AEDVVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPR 466
            ..:|:..:  |::::...||.||||.||||||||:||||:|||||...:||.|.:.|::|:..|
Human   440 TDVVIKMLQTAKNLLKEEKLVHSYPYDWRTKKPVVIRASKQWFINITDIKTAAKELLKKVKFIP- 503

  Fly   467 ANAEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLNSALIEHLCNLLRKEGSIDF 531
               .::...::..:.:||||||||||.|||||||.:.:...:.::||...||:..|:.:.|| |.
Human   504 ---GSALNGMVEMMDRRPYWCISRQRVWGVPIPVFHHKTKDEYLINSQTTEHIVKLVEQHGS-DI 564

  Fly   532 WWVKSVEELVPEHLLREL-HHEAKDLVKGTDILDIWFDSGSTWSAVL-GKDKIADLYLEGYDQFT 594
            ||....|:|:|:.:|.|: ..:|.:.|.|.||||||||||::||.|| |.|:.|||||||.||..
Human   565 WWTLPPEQLLPKEVLSEVGGPDALEYVPGQDILDIWFDSGTSWSYVLPGPDQRADLYLEGKDQLG 629

  Fly   595 GWFQSSLLMSIAARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQITK---------KYGTD 650
            ||||||||.|:|||:.||||.:.|||||:.|||.||||||||||.|..:..         .||.|
Human   630 GWFQSSLLTSVAARKRAPYKTVIVHGFTLGEKGEKMSKSLGNVIHPDVVVNGGQDQSKEPPYGAD 694

  Fly   651 ALRWWVASHGTQHMSITVSDKLLQQAAENLCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSYLNRY 715
            .||||||.... ...:.:...:|..|.:::.|:|.|:|:|.|.:.:.......|..:|...:::|
Human   695 VLRWWVADSNV-FTEVAIGPSVLNAARDDISKLRNTLRFLLGNVADFNPETDSIPVNDMYVIDQY 758

  Fly   716 LLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYC--GDDHELLAIRQTL 778
            :|..|.:..:::.:||:.|::.:||..::.|...::|..|..:|||||||  .:|.:..:.:..|
Human   759 MLHLLQDLANKITELYKQYDFGKVVRLLRTFYTRELSNFYFSIIKDRLYCEKENDPKRRSCQTAL 823

  Fly   779 THCYQQLCKSLWPIVPFLVEESWS---YYDTTGGAFHEQIVQTNPEWQDTKATEVINAAFDVKRL 840
            ......:.:|..||:|.|.||.:.   |.......|....:.|:..|:.....|.:.:|..::
Human   824 VEILDVIVRSFAPILPHLAEEVFQHIPYIKEPKSVFRTGWISTSSIWKKPGLEEAVESACAMR-- 886

  Fly   841 INQQAGDVNTWHLAVTIKGKERSQ------------LDLLRELHSPLGESVSNSELCEILQVGSV 893
             :...|         :|.||..::            .:::..|.|.  |:.|.|:|.|::.....
Human   887 -DSFLG---------SIPGKNAAEYKVITVIEPGLLFEIIEMLQSE--ETSSTSQLNELMMASES 939

  Fly   894 TLL----QSHNSDLDIALSKLQISL----------------------CPRCRRYGLEDEQKTCQR 932
            |||    :...:|:.....|..|:|                      ||||.:|..|.....|.|
Human   940 TLLAQEPREMTADVIELKGKFLINLEGGDIREESSYKVIVMPTTKEKCPRCWKYTAESSDTLCPR 1004

  Fly   933 CSDVMEAK 940
            |::|:..|
Human  1005 CAEVVSGK 1012

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IleRS-m	NP_648837.2	IleS	26..936	CDD:439830	382/976 (39%)
IARS2	NP_060530.3	IleS	60..1011	CDD:439830	383/979 (39%)
		'HIGH' region. /evidence=ECO:0000305	116..126		6/9 (67%)
		'KMSKS' region. /evidence=ECO:0000305	664..668		3/3 (100%)