DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IleRS-m and ValRS

DIOPT Version :9

Sequence 1:	NP_648837.2	Gene:	IleRS-m / 39762	FlyBaseID:	FBgn0036569	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001260946.1	Gene:	ValRS / 45783	FlyBaseID:	FBgn0027079	Length:	1055	Species:	Drosophila melanogaster

Alignment Length:	1076	Identity:	233/1076 - (21%)
Similarity:	400/1076 - (37%)	Gaps:	285/1076 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 RLYSMKAAKKDAKKYTDTINLPKTKFPNRLTAAKREEQERLVLENKIAVSYAYQ----EQR---- 68
            ||.:.|.||..||       |.|..........|:|:.|:...|.|.|..|..|    |::
  Fly    31 RLKAEKLAKLQAK-------LDKKAAAAPAAGEKKEKPEKRTKEVKEAAVYTAQTAPGEKKDLSG 88

  Fly    69 -------------------------LAEKGKPT---------FVLHDGPPYANGQLHMGHAVNKI 99
                                     ..|.|:.:         ||:...||...|.||:|||:...
  Fly    89 ALPDAYSPRYVEAQWYSWWEKEGFFTPEYGRASIDAPNPNGKFVMIIPPPNVTGSLHLGHALTNA 153

  Fly   100 LKDITLRQRVAHGQRVNYIPGWDCHGLPIEL---KATSTAPGQSAQEI-RQK--SRAFAWEAIKS 158
            ::|...|.....|:...::||.|..|:..::   |........|..:: |:|  .|.:.|...|.
  Fly   154 IEDAITRYHRMKGRTTLWVPGCDHAGIATQVVVEKLLWRDEKLSRHDLGREKFIERIWDWRREKG 218

  Fly   159 QK--EEFSSWGILANWQKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAE 221
            .:  |:..|.|...:|.:  :..|..|:......|.|..|:|:|.:||..:.|.||.:.|:|:::
  Fly   219 GRIYEQLKSLGSSYDWTR--VAFTMDPKLCRAVTEAFVRLHEEGSIYRSSRLVNWSCTLRSAISD 281

  Fly   222 AELE--------------YDANHISPSVYVRFALNPSSFDVKDKQIYALVWTTTPWTLPSNQAIC 272
            .|::              |: :.:...|.::||.   ..:..|::|  :|.||...|:..:.|:.
  Fly   282 IEVDKVEIPGRTFLSIPGYE-DKVEFGVLIKFAY---KVEGSDEEI--IVATTRIETMLGDTAVA 340

  Fly   273 YNASLEYVIVRLSDRNQDELYLMASALMADFEANTQLKCEIVQHLSGELLSKLSYNHPIDKEQSN 337
            .:.             ||:.|                     :||.|:.:.     ||....:
  Fly   341 VHP-------------QDDRY---------------------KHLHGKFVV-----HPFSTRR-- 364

  Fly   338 LPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPDFLR------G 396
            ||......|..:.|||.|...|||.|.|:.|.....:|.....|::|....:..:|..      .
  Fly   365 LPIVCDEFVDMAFGTGAVKITPAHDPNDYEVGKRCNLPFITIFNDDGYIIGDYGEFTGMKRFECR 429

  Fly   397 KSVLDQGNSLVLDRIAEDVVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALE-- 459
            |.:|::..:|.|.|   :.:::..:   .||..|:|..|......||:::...:...|.:|:.
  Fly   430 KKILEKLKALNLYR---ETLNNPMV---VPICSRSKDVVEPLIKPQWYVSCSDMAASATEAVRSG 488

  Fly   460 QVEIYPRANAEASKKALLTQLQKRPYWCISRQRAWGVPIPVLY------SRESGKVVLNSALIEH 518
            :::|.|    |...|.....:.....||:|||..||..||..:      |.::|    :||
  Fly   489 ELKIIP----EHHTKTWYHWMDGIRDWCVSRQLWWGHRIPAYHVSFTDPSLQTG----SSA---- 541

  Fly   519 LCNLLRKEGSI---DFWWVKSVEELVPEHLLRELHHEAKD-----LVKGTDILDIWFDSGSTWSA 575
                   .||:   :.:|:.:..|  .|.|.:.......|     |.:..|:||.||.||....:
  Fly   542 -------HGSVNDDEQYWIVARSE--AEALTKAAERFGVDASKIVLKQDEDVLDTWFSSGIFPFS 597

  Fly   576 VLG-KDKIADL-------YLE-GYDQFTGW------FQSSLLMSIAARECAPYKALFVHGFTVDE 625
            |.| .|:..||       .|| |:|....|      |...||..:      |:|.:::|....|.
  Fly   598 VFGWPDQTKDLQTFYPTSLLETGHDILFFWVARMVFFGQKLLGKL------PFKEVYLHPMVRDA 656

  Fly   626 KGYKMSKSLGNVISPKQITK-------------------------------------KYGTDALR 653
            .|.||||||||||.|..:.:                                     :.|:||||
  Fly   657 HGRKMSKSLGNVIDPMDVIRGITLEGLHAQLVGSNLDPREIEKAKAGQKQDYPQGIPECGSDALR 721

  Fly   654 WWVASHGTQHMSITVS-DKLLQQAAENLC-KIRGTMRY-LKGVIGEKQSGEKLIRTSDKSYLNRY 715
            :.:.::.||...|.:. :::|  .....| |:....:: |....|.::...:|..::..:.::.:
  Fly   722 FALCAYITQARDINLDINRVL--GYRFFCNKLWNATKFALLYFTGSEKFDTELSASAAINQMDAW 784

  Fly   716 LLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLYCGDDHELLAIRQTLTH 780
            :||:|..........:::|::....:....|....:..||:..:|.....|.:.:..|.|:||..
  Fly   785 ILSRLAAAIEACNTGFESYDFAAATSACYAFWLYDLCDVYLECLKPIFQSGSEEQQTAARRTLYV 849

  Fly   781 CYQQLCKSLWPIVPFLVEESWSYYDTTGGAFHEQIVQTNP-------------EWQDTKATEVIN 832
            |.....:.|.|.:||:.||           .::::.:.||             .|:.||....:.
  Fly   850 CLDYGLRLLSPFMPFITEE-----------LYQRLPRANPAPSICVASYPSNTSWRSTKIESDVE 903

  Fly   833 AAFDVKRLINQQAGDVNTWHLAVTIKGKERSQL----------DLLRELHSPLGESVSNSEL--- 884
            ......|:|.....|.|       :..|.::::          ::|:...|.|......|.:
  Fly   904 FVQKAARIIRSARSDYN-------LPNKVKTEVYIVCTDSVPSEILKRYASDLATISYCSNVVFD 961

  Fly   885 ------CEILQVG---SVTLLQSHNSDLDIALSKLQ 911
                  |.||.|.   .|.||.....:.|..::|||
  Fly   962 SPAPQGCAILTVTGQCEVHLLLKGLVEADKEIAKLQ 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS-m	NP_648837.2	ileS	26..938	CDD:235588	226/1062 (21%)
		nt_trans	75..>211	CDD:294020	38/152 (25%)
		nt_trans	<434..658	CDD:294020	71/291 (24%)
		Anticodon_Ia_Ile_BEm	668..842	CDD:153414	32/189 (17%)
ValRS	NP_001260946.1	PTZ00419	80..1053	CDD:240411	216/1020 (21%)
		ValRS_core	129..736	CDD:185677	162/688 (24%)
		tRNA-synt_1_2	307..436	CDD:290334	37/174 (21%)
		Anticodon_Ia_Val	736..873	CDD:153416	26/149 (17%)
		Val_tRNA-synt_C	978..1053	CDD:287436	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446756
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840