DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IleRS-m and SPCC18B5.08c

DIOPT Version :9

Sequence 1:	NP_648837.2	Gene:	IleRS-m / 39762	FlyBaseID:	FBgn0036569	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_587938.1	Gene:	SPCC18B5.08c / 2539323	PomBaseID:	SPCC18B5.08c	Length:	973	Species:	Schizosaccharomyces pombe

Alignment Length:	991	Identity:	344/991 - (34%)
Similarity:	528/991 - (53%)	Gaps:	119/991 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 AAKKDAKKYTDTINLPKTKFPNRLTAAKREEQERLVLENKIAVSYAYQEQRLAEKGKPTFVLHDG 82
            :::.|.|||::::.||||.||.:.......|:....:.:.:   |.:|::.|.:  :.:|||.||
pombe    26 SSQADLKKYSESLCLPKTSFPIKPNVKGNNEKYFKSITSDL---YEWQKENLNK--EDSFVLLDG 85

  Fly    83 PPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIPGWDCHGLPIELKA-TSTAPGQSAQEIRQ 146
            ||:|||:||:|||:|||||||..|.::..|:.|:|:|||||||||||.|| .:.|..:|:.|||:
pombe    86 PPFANGRLHIGHALNKILKDIINRWQLLKGRSVHYVPGWDCHGLPIESKAIKANAERKSSLEIRK 150

  Fly   147 KSRAFAWEAIKSQKEEFSSWGILANWQKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYW 211
            .::.||..|::.|...|....::.:|  .:.|:|...:|.:.:|::|.:|.:|.|::|..|||||
pombe   151 IAKDFANSAVQEQLMMFQRMAVMGDW--PSRYITMSDKFEIAELKVFLSLLQKDLIFRQNKPVYW 213

  Fly   212 SPSSRTALAEAELEYDANHISPSVYVRFALNPSSFD-VKDKQIYALVWTTTPWTLPSNQAICYNA 275
            |.|||:||||:|:|||.||:|.|:|..|.:|..|.| .:...:.||||||||||:|||.|:.|:.
pombe   214 SSSSRSALAESEIEYDDNHVSTSIYFTFPVNSFSIDGCEYNNVKALVWTTTPWTIPSNLALSYHP 278

  Fly   276 SLEYVIVRLSDRNQDELYLMASALMADFE----ANTQLKCEIVQHLSGELLSKLSYNHPIDKEQS 336
            .:.|.:.    ::.:.:|||:..|:.:.:    |.....|      ..:::|..:|.:|:..:||
pombe   279 EINYGLY----QHNNSIYLMSDNLVPNLDFMQGAKRLASC------PSDIISSFTYENPLLPKQS 333

  Fly   337 NLPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSLTQKIPVKCFVNEEGTYTKEAPD-FLRGKSVL 400
             .||..:::|.:..|||:||.||.||.||:|:.|...:.....:::.|.|||||.| .|.|..||
pombe   334 -FPFLQSNYVTNDIGTGIVHVAPGHGMEDYLLGLENNLRPFSPLDDYGRYTKEALDGSLEGLEVL 397

  Fly   401 DQGNSLVLDRIAED--VVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQVEI 463
            ..|...|:..:...  :|..|..:|.||.||||.||:|:||:.||||:.|..:..|..||:.|::
pombe   398 GDGGKKVISIMKNQNMIVKVSPYKHRYPYDWRTHKPLILRATPQWFISLENERKTAIKALDSVKM 462

  Fly   464 YPRANAEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLNSALIEHLCNLLRKEGS 528
            .|    ..|:..||..|..||.||||||||||:||||||.:.:...:|....:.::...:..||
pombe   463 IP----PNSRARLLGFLNGRPEWCISRQRAWGLPIPVLYEKGTKIPLLTVKSVSYIIEKMEVEG- 522

  Fly   529 IDFW-----------WVKSVEELVPEHLLRELHHEAKDLVKGTDILDIWFDSGSTWSAVL-GKDK 581
            :|.|           ||.      |:       :..|:.::||:.||:|||||::|:.:. .|:|
pombe   523 VDSWFNDTENNGHAQWVH------PD-------YRNKEYIRGTETLDVWFDSGTSWTTIAPRKNK 574

  Fly   582 -IADLYLEGYDQFTGWFQSSLLMSIA--ARECAPYKALFVHGFTVDEKGYKMSKSLGNVISPKQI 643
             :.||.|||.||..|||||.||...|  ::..||:..||.|||..||:|.|.|||||||..|:.:
pombe   575 PLIDLCLEGSDQHRGWFQSLLLTYTAYQSKPEAPFSTLFTHGFIFDERGQKQSKSLGNVTDPEDV 639

  Fly   644 T-------KK--YGTDALRWWVASHGTQHMSITVSDKLLQQAAENLCKIRGTMRYLKGVIGEKQS 699
            .       ||  ||.|.||.||||..:.: ...:...:|.|..|:|.|.|.|.|:..|.:.:..:
pombe   640 INGKLLKGKKLPYGVDLLRLWVASCDSTN-DTNLGPNILTQVGESLKKWRLTSRFCLGNLHDWNT 703

  Fly   700 GEKLIRTSDKSYLNRYLLSQLVEFESEVEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRLY 764
            ... :...:...:::..|.||.:|::|:.:||::|..|:||..:..|:.:.:|:.|...:|||||
pombe   704 SSS-VDVGELRGIDKLALVQLDKFQTEIRELYESYSINKVVHHLNYFMNSFLSSTYFDAVKDRLY 767

  Fly   765 CGDDHELLAIRQTLTHCYQQLCKSLW---PIVPFLVEESW---------SYYDTTGGAFHEQIVQ 817
             .|....::.|...|..|..|...:|   ||.|.|.:|.|         |.|.|...|....::.
pombe   768 -ADLPNSVSRRSVQTVLYHSLLTLIWAISPITPLLAQEIWQSLPDSYLNSSYQTPFHAGETHLIS 831

  Fly   818 TNPEWQDTKATEVINAAFDVKR-LINQQ-----------AGD----VNTWHLAVTIKGKERSQLD 866
            :.     ....::::..|.:|. |:.||           |.:    .|:....|.||.|.:|.|.
pombe   832 SL-----RSKVDLLDRKFLIKEYLVLQQLKYSINLLITAARENLTIKNSLEAYVVIKSKSQSLLS 891

  Fly   867 LLRELHSPL-----GESVSNSELCEILQVGSVTLLQSHNSDLDIALSKLQI-----SLCPRCRRY 921
            .|:...|.|     ...|..:|:.|.|::.|||   .....||..::.:.:     ..|.||..:
pombe   892 FLKNYSSDLPFLFNTSKVFINEIPENLKLASVT---QPEVQLDYGVANISLFFSNQQKCLRCWMH 953

  Fly   922 GLEDEQKTCQRCSDVM 937
             ...|...|.||..|:
pombe   954 -TAHEDGLCDRCESVL 968

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS-m	NP_648837.2	ileS	26..938	CDD:235588	341/983 (35%)
		nt_trans	75..>211	CDD:294020	62/136 (46%)
		nt_trans	<434..658	CDD:294020	100/247 (40%)
		Anticodon_Ia_Ile_BEm	668..842	CDD:153414	47/186 (25%)
SPCC18B5.08c	NP_587938.1	IleS	32..972	CDD:223138	343/985 (35%)
		IleRS_core	78..666	CDD:173909	253/618 (41%)
		Anticodon_Ia_Ile_BEm	672..860	CDD:153414	49/194 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	440	1.000	Domainoid score	I77
eggNOG	1	0.900	-	-		E1_COG0060
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7118
Inparanoid	1	1.050	517	1.000	Inparanoid score	I222
OMA	1	1.010	-	-		QHG60783
OrthoFinder	1	1.000	-	-		FOG0003995
OrthoInspector	1	1.000	-	-		oto101679
orthoMCL	1	0.900	-	-		OOG6_101646
Panther	1	1.100	-	-	LDO	PTHR42765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1444
SonicParanoid	1	1.000	-	-		X2759
TreeFam	1	0.960	-	-
	14	13.860