Protein Alignment IleRS-m and Iars1

DIOPT Version :10

• Sequence 1: NP_648837.2
• Gene: IleRS-m / 39762
• FlyBaseID: FBgn0036569
• Length: 941
• Species: Drosophila melanogaster
• Sequence 2: NP_742012.2
• Gene: Iars1 / 105148
• MGIID: 2145219
• Length: 1262
• Species: Mus musculus
• Alignment Length: 854
• Identity: 245/854 - (28%)
• Similarity: 382/854 - (44%)
• Gaps: 188/854 - (22%)

  Fly    53 VLENKIAVSYAYQEQRLAE---------------KGKPTFVLHDGPPYANGQLHMGHAVNKILKD 102
            |.||   :|:..:|:::.|               |.:|.|..:||||:|.|..|.||.:...:||
Mouse     5 VPEN---ISFPAEEEKILEFWSKHNCFQECLKQSKLRPKFTFYDGPPFATGLPHYGHILAGTIKD 66

  Fly   103 ITLRQRVAHGQRVNYIPGWDCHGLPIELKATST----APGQSAQ----EIRQKSRAFA------W 153
            |..|.....|..|:...||||||||:|.:...|    .|...|:    |..::.||..      |
Mouse    67 IVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIKGPEDVAKMGIAEYNKQCRAIVMRYSAEW 131

  Fly   154 EAIKSQKEEFSSWGILANW-QKDNIYMTFQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRT 217
            ::..::         |..| ..||.|.|..|:|:.:...:|..||:||||||.:|.:.:|.:..|
Mouse   132 KSTVTR---------LGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACGT 187

  Fly   218 ALAEAELEYDANHI-SPSVYVRFALNPSSFDVKDKQIYALVWTTTPWTLPSNQAICYNASLEYVI 281
            .|:..|...:...: .|||:|.|.|.      :|:....:.|||||||||||.|:|.|..::|
Mouse   188 PLSNFESNQNYKDVQDPSVFVTFPLE------EDENTSLVAWTTTPWTLPSNLALCVNPEIQY-- 244

  Fly   282 VRLSDRNQDELYLMASA-LMADFEANTQLKCEIVQHLSGELLSKLSYNHPID-----KEQSNLPF 340
            |::.|..:.:|:::..| |.|.::..:..  ||::...|..|....|....|     ||......
Mouse   245 VKIKDVARGKLFILTEARLSALYKQESDY--EILERFPGASLKGKKYKPLFDYFIKCKENGAFTV 307

  Fly   341 FDASHVQDSKGTGLVHTAPAHGPEDFLV----SLTQK--IPVKCFVNEEGTYTKEAPDFLRGKSV 399
            ....:|:|.:|||:||.||..|.:|..|    ::.||  :|| |.|:..|.:|:|...|: |:.|
Mouse   308 LVDHYVKDEEGTGVVHQAPYFGADDHRVCMDFNIIQKDSVPV-CPVDASGCFTEEVTHFV-GQYV 370

  Fly   400 LDQGNSLVLDRIAED---VVHSSKLEHSYPIDWRTKKPVIIRASEQWFINTEKLKTPAADALEQ- 460
            .|...:::  |:.::   ::.:....||||..||:..|:|.::...||:..|    |..|.|.:
Mouse   371 KDADKNII--RMLKEQGRLLAAGTFTHSYPFCWRSDTPLIYKSVPSWFVRVE----PMVDQLLKN 429

  Fly   461 ------VEIYPRANAEASKKALLTQLQKRPYWCISRQRAWGVPIPVLYSRESGKVVLNSALIEHL 519
                  |..:.|      :|.....|::...|.|||.|.||.|||:..|.:..:||
Mouse   430 NDLCYWVPEFVR------EKRFGNWLKEARDWAISRNRYWGTPIPLWVSEDLEEVV--------- 479

  Fly   520 CNLLRKEGSIDFWWVKSVEELVPEHL----LRELHHEAKD------------LVKGTDILDIWFD 568
            |             :.||.||  |.|    :.:||.|:.|            |.:.:::.|.||:
Mouse   480 C-------------IGSVAEL--EELSGTKISDLHRESIDHLTIPSRCGKAPLRRVSEVFDCWFE 529

  Fly   569 SGSTWSAVLG---------KDKI-ADLYLEGYDQFTGWFQSSLLMSIAARECAPYKALFVHGFTV 623
            |||...|.:.         :|.. ||...||.||..|||.:.|:::.|.....|:|.:.|:|..:
Mouse   530 SGSMPYAQVHYPFESKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLIL 594

  Fly   624 DEKGYKMSKSLGNVISPKQITKKYGTDALRWWVASHGTQHMSITVSDKLLQQAAENL-CKIRGTM 687
            ...|.||||...|...|..|..|||.||||.::           ::..:::  |||| .|..|..
Mouse   595 ASDGQKMSKRKKNYPDPVSIIDKYGADALRLYL-----------INSPVVR--AENLRFKEEGVR 646

  Fly   688 RYLKGVI------------------GEKQ----SGEKLIRTS----DKSYLNRYLLSQLVEFESE 726
            ..||.|:                  .|::    ..|..:|.|    |:..|: ::.|.|..||:|
Mouse   647 DVLKDVLLPWYNAYRFFIQNVFRLHKEEEVKFLYNEHTVRESPNITDRWVLS-FMQSLLGFFETE 710

  Fly   727 VEKLYQAYEYNRVVACVQNFIANQVSAVYVHLIKDRL--YCGDDHELLAIRQTLTHCYQQLCKSL 789
            :    .||....||..:..|: :.::..||.:.:.||  ..|.:..::|: :||......||:.:
Mouse   711 M----AAYRLYTVVPRLVKFV-DILTNWYVRMNRRRLKGESGVEDCVMAL-ETLFSVLLSLCRLM 769

  Fly   790 WPIVPFLVE 798
            .|..|||.|
Mouse   770 APYTPFLTE 778

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IleRS-m	NP_648837.2	IleS	26..936	CDD:439830	245/854 (29%)
Iars1	NP_742012.2	PLN02882	6..1070	CDD:215477	244/853 (29%)
		'HIGH' region	48..58		4/9 (44%)
		'KMSKS' region	600..604		3/3 (100%)