DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IleRS-m and iars2

DIOPT Version :9

Sequence 1:	NP_648837.2	Gene:	IleRS-m / 39762	FlyBaseID:	FBgn0036569	Length:	941	Species:	Drosophila melanogaster
Sequence 2:	NP_001120515.1	Gene:	iars2 / 100145647	XenbaseID:	XB-GENE-987849	Length:	992	Species:	Xenopus tropicalis

Alignment Length:	1015	Identity:	397/1015 - (39%)
Similarity:	566/1015 - (55%)	Gaps:	101/1015 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRIF-------YFRVGNRLYSMKAAKKDA---KKYTDTINLPKTKFPNRLTAAKREEQE-RLVL 54
            |||:.       .:|.|.|..|.||:..::   :||..|:.||.|.||.|....:....| ||..
Frog     1 MLRLLRCRLPVRRYRWGVRAASEKASSNESPGNRKYRGTVLLPHTDFPIRRGPGETASTELRLQE 65

  Fly    55 ENKIAVSYAYQEQRLAEKGKPTFVLHDGPPYANGQLHMGHAVNKILKDITLRQRVAHGQRVNYIP 119
            |:.....||:|.:|   |.|..|.||||||||||..|:|||:||||||||.|..:..|.:|:|:|
Frog    66 ESGFLQLYAWQRER---KTKKEFSLHDGPPYANGDPHVGHALNKILKDITNRFHMMRGYKVSYVP 127

  Fly   120 GWDCHGLPIELKATS----TAPGQSAQEIRQKSRAFAWEAIKSQKEEFSSWGILANWQKDNIYMT 180
            |||||||||||||.:    .|...|..|||:|::.||.:||:.||..|..|||:|:|  |..|.|
Frog   128 GWDCHGLPIELKALAELGEEAENMSPTEIRRKAKMFAEKAIEKQKSSFIRWGIMADW--DKCYYT 190

  Fly   181 FQPEFIVNQLEMFYNLYEKGLVYRDLKPVYWSPSSRTALAEAELEYDANHISPSVYVRFALN--- 242
            |.|::...||::||.:|:||.:|:|.|||:||||:|||||||||||:..|||.|::.:|.::
Frog   191 FDPKYEAKQLDIFYKMYDKGHIYQDYKPVFWSPSTRTALAEAELEYNQEHISRSIFAKFPMHKAP 255

  Fly   243 PSSFDVKD--KQIYALVWTTTPWTLPSNQAICYNASLEYVIVRLSDRNQDELYLMASALMADFEA 305
            |....:.|  ..:..|||||.|||:|:||||||....||.|.:.:  |..|.|::|:..:.....
Frog   256 PKLASIIDGSSAVSTLVWTTQPWTIPANQAICYMPDTEYAIAKCA--NTGEQYILATDRIESTAL 318

  Fly   306 NTQLKCEIVQHLSGELLSKLSYNHPIDKEQSNLPFFDASHVQDSKGTGLVHTAPAHGPEDFLVSL 370
            :...:.:::....|..|......||...::.: |...|:||..:|||||||||||||.||:.|:.
Frog   319 SLGTQLQVISTFKGLDLEGGICLHPTIADRLS-PLLPANHVTMAKGTGLVHTAPAHGIEDYSVAS 382

  Fly   371 TQKIPVKCFVNEEGTYTKEAPDFLRGKSVLDQGNSLVLDRIAEDVVHSSK-------LEHSYPID 428
            ..|:||.|.|:|.|.:|..|...|..|:||..||..|:     .::|:||       ..||||.|
Frog   383 HHKLPVDCLVDESGHFTTGAGAELENKAVLTDGNETVI-----QMLHASKSLLKEESFVHSYPYD 442

  Fly   429 WRTKKPVIIRASEQWFINTEKLKTPAADALEQVEIYPRANAEASKKALLTQLQKRPYWCISRQRA 493
            ||||||||||||:|||:||..:|..|.|.|::|:..| |:|.|   .:|..|.:|.||||||||.
Frog   443 WRTKKPVIIRASKQWFVNTANIKDKAQDVLKKVKFVP-ASAAA---RMLEMLDRRTYWCISRQRG 503

  Fly   494 WGVPIPVLYSRESGKVVLNSALIEHLCNLLRKEGSIDFWWVKSVEELVPEHLLRELH--HEAKDL 556
            |||||||.|.:|:||.::|...:.|:.:|:.:.|: |.||...:|||:|:.:|:::.  .:|.|.
Frog   504 WGVPIPVFYHKETGKPLINRHSVGHIMSLVEQHGT-DVWWTLPLEELLPKAVLQKVEGSSDACDY 567

  Fly   557 VKGTDILDIWFDSGSTWSAVL--GKDKIADLYLEGYDQFTGWFQSSLLMSIAARECAPYKALFVH 619
            .:|.|:||||||||::|:.||  |:.: ||:|:||.||..||||||||.|:|||..|||:.:.||
Frog   568 EQGRDVLDIWFDSGTSWAHVLEDGEQR-ADVYMEGKDQLGGWFQSSLLTSVAARNKAPYRNIIVH 631

  Fly   620 GFTVDEKGYKMSKSLGNVISPKQITK---------KYGTDALRWWVASHGTQHMSITVSDKLLQQ 675
            |||:.|||.|||||:|||:.|..:..         .||.|.||||||.... ...:.:...:|..
Frog   632 GFTLSEKGEKMSKSVGNVVDPDVVINGGQDKVNEPAYGADVLRWWVAESNV-FTEVLIGPAVLNS 695

  Fly   676 AAENLCKIRGTMRYLKGVIGEKQSGEKLIRTSDKSYLNRYLLSQLVEFESEVEKLYQAYEYNRVV 740
            |.:::.|:|.|:|::.|.:.:.......:.:::...:::|:|..|.::.|:|...|:.||:.:||
Frog   696 ARDDINKLRNTLRFMLGNLSDFTPERDSVPSTEMYVIDQYMLHILQDYGSKVTDAYKGYEFGKVV 760

  Fly   741 ACVQNFIANQVSAVYVHLIKDRLYCGD--DHELLAIRQTLTHCYQQLCKSLWPIVPFLVEESWSY 803
            ..::..:...:|:.|..:|||||||.:  |.:..:.:..|......:.:|..||:|.|.||.:.|
Frog   761 RLLEALVTRDLSSFYFSIIKDRLYCDEEKDPKRRSCQTVLAEALDVVVRSFAPILPHLAEEVFQY 825

  Fly   804 Y---DTTGGAFHEQIVQTNPEWQDTKATEVINAAFDVKRLINQQAGDVNTWHLAVTIKGKERSQL 865
            .   ..:..||....::.|..|:.....|.|.||..::..........|.....|||      .:
Frog   826 LPYRKESDSAFRTGWIKPNTVWKKLGLVEAIEAACSIRDAFLGSIPGKNAAEYEVTI------VI 884

  Fly   866 D--LLRELHSPLGESVSN--SELCEILQVGSVTLLQSHNSDLDIALSKLQISL------------ 914
            |  ||.||...|.|..|:  |:|.|:|.....:||.....||....|.|:.|.
Frog   885 DPGLLFELMETLQEEPSSCTSQLNELLMCSQTSLLSDLPLDLPPEASVLKGSFLINLEDGDICQE 949

  Fly   915 --------------CPRCRRYGLEDEQKTCQRCSDVMEAK 940
                          |||||:|........|.||.:.:..|
Frog   950 EAYKVVVQPSRKERCPRCRKYTAASSLAPCARCLEAIAGK 989

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IleRS-m	NP_648837.2	ileS	26..938	CDD:235588	386/976 (40%)
		nt_trans	75..>211	CDD:294020	76/139 (55%)
		nt_trans	<434..658	CDD:294020	118/236 (50%)
		Anticodon_Ia_Ile_BEm	668..842	CDD:153414	44/178 (25%)
iars2	NP_001120515.1	ileS	35..988	CDD:235588	387/978 (40%)
		nt_trans	83..>221	CDD:294020	76/139 (55%)
		tRNA-synt_1_2	<331..>388	CDD:290334	25/57 (44%)
		nt_trans	<448..685	CDD:294020	119/243 (49%)
		Anticodon_Ia_Ile_BEm	688..867	CDD:153414	44/178 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	557	1.000	Domainoid score	I239
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7118
Inparanoid	1	1.050	671	1.000	Inparanoid score	I737
OMA	1	1.010	-	-		QHG60783
OrthoDB	1	1.010	-	-		D101703at33208
OrthoFinder	1	1.000	-	-		FOG0003995
OrthoInspector	1	1.000	-	-		oto104585
Panther	1	1.100	-	-	LDO	PTHR42765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2759
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080