DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATPsynbetaL and ECM5

DIOPT Version :9

Sequence 1:	NP_648836.2	Gene:	ATPsynbetaL / 39761	FlyBaseID:	FBgn0036568	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_013901.1	Gene:	ECM5 / 855214	SGDID:	S000004788	Length:	1411	Species:	Saccharomyces cerevisiae

Alignment Length:	738	Identity:	133/738 - (18%)
Similarity:	237/738 - (32%)	Gaps:	254/738 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SWAKMATACARIGLKMG--PGTGGYRGNYLGNPVVFPRYLHASLSLWDDKDKKKSGDECEPEPQE 66
            ||.:.::..|:...|||  ||..       .|.::....|:::                .|..::
Yeast   682 SWLRFSSEAAKWTSKMGFLPGLD-------VNQLLINALLNSN----------------NPVLRK 723

  Fly    67 VCKTDAELVKK--KDEAEDECEEKKSDGGGKKL-ESKGRKGVIHAVIGPVIDVYFE----EEVPE 124
            .|:   :|:..  .:|||:          .||| |..|...|::..:..:.|:..|    .::..
Yeast   724 KCR---DLISNYVVEEAEN----------SKKLGELIGTVDVVYNKLNYISDISLESTGLSKIVV 775

  Fly   125 VLNALQVQDAPIANLVLEVFHHLGNNIVRCVAMDSTEGLRR---GQPVLDTGYPIRVAV----GK 182
            ...|||      .||.|:.|         .|.::..|....   |.|:.|....:.|.:    ..
Yeast   776 THGALQ------RNLSLKEF---------VVLLEKPENGAHSICGIPIRDQSGNLNVCLHSYFDS 825

  Fly   183 AVLGRILNVVGDPIDDRGEVKSDFYSFIHNEAPELTDLSVKPEILVTG--------IKVIDLLAP 239
            |.||..|:.:..|        ...|..:|||     |...|.::|:|.        :.:|..|..
Yeast   826 ASLGIALDGLDKP--------PTSYLLVHNE-----DFEKKWDVLMTSTFRNRTVPLNIIQYLIS 877

  Fly   240 YVKGG-KIGLFGGAGVGKTVLIMELINNIAKSHGGYSVFV-----GAGERTREGNDLYHEMIESK 298
            :.... :......:....::|::|......|:....|..|     |.|...|.....:.:.:...
Yeast   878 HTDSNTEFNRMLRSNFDDSLLLIEKCKKFIKTFVDVSCSVKDVDFGNGFNLRHLPLKFSDNMADN 942

  Fly   299 VISLEDDSSKVVLVFGQMNEPPGAR-----------SRVVLTG-------------LTI---AEY 336
            :.||.:...|..:.|.:  :|...|           :|.::.|             |||   ..|
Yeast   943 LESLYESVRKCSIEFSE--KPTIIRLYHVSRQFPIDNRDIIDGNNLDLLKELYQKSLTIPLKVSY 1005

  Fly   337 FR-----------------------DVDGQD------VLLFIDNIFRFTQAGSEVSALLGRIPSA 372
            :.                       |:..:|      .||:....|......||....||.:...
Yeast  1006 WTKLTRKICRLEWLSVYEHIFIERCDIKNEDPAKYSLPLLYSYFEFGLKYCDSEDIDKLGEVRKL 1070

  Fly   373 V-GYQPTLGTDMGTMQE-RITSTRNG----SITSVQAVYVPADDLSDPAPAATFSHLDATTVLSR 431
            : .||     ||  ||: |:...::.    |::.::.|.:..::...|..::.||.||..
Yeast  1071 ILKYQ-----DM--MQKVRVFLKKDPPSKISLSDLEDVLLDIEEYRLPIQSSFFSELDYV----- 1123

  Fly   432 PIAELG----------IYPA--VDPLDSSSRILDPDVVG-EEHYNVARAVQKTLQAYKSLQDIIA 483
             |.|:.          :|..  :|.:|...|..||..|. ...:|.:|..::.|.:..|
Yeast  1124 -IREIENAKKMNDVNILYNTDNIDKIDELIRKNDPKFVKFANQFNGSRLDKRPLASDNS------ 1181

  Fly   484 ILGMDELSEEDKL---------TVARARKMQRFLSQPFQVAEIFTGHPGKLVPVEKC-------- 531
              |..:..:|.|:         .:.:..|....|...|:..::   ...|.:|:|.|
Yeast  1182 --GSVKAKQELKVFKLWNQHLDQIMQKNKFIEILPSIFRCLDL---KSDKYIPLESCSKRQTKYC 1241

  Fly   532 -----VEGFKR--------------LLNGEY--DDIPEIAF-------------------YMVGD 556
                 .||...              :.|||.  .|.|.:.|                   :.:.|
Yeast  1242 FCRRVEEGTAMVECEICKEWYHVDCISNGELVPPDDPNVLFVCSICTPPCMAVDNIEGVTFELDD 1306

  Fly   557 AEEVLAKATQLAASMSGDAPPAK 579
            .:.:|.::.:|  |:..|.|..|
Yeast  1307 LKRILVESLKL--SLIPDPPILK 1327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPsynbetaL	NP_648836.2	PRK09280	103..568	CDD:236447	107/621 (17%)
		ATP-synt_ab_N	106..173	CDD:280947	14/73 (19%)
		F1-ATPase_beta	175..454	CDD:238553	65/370 (18%)
		ATP-synt_ab_C	462..571	CDD:278722	25/165 (15%)
ECM5	NP_013901.1	BRIGHT	187..280	CDD:128777
		cupin_RmlC-like	512..662	CDD:424065
		PHD_Ecm5p_Lid2p_like	1240..1287	CDD:276993	8/46 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900