DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATPsynbetaL and KDM5A

DIOPT Version :9

Sequence 1:NP_648836.2 Gene:ATPsynbetaL / 39761 FlyBaseID:FBgn0036568 Length:622 Species:Drosophila melanogaster
Sequence 2:NP_001036068.1 Gene:KDM5A / 5927 HGNCID:9886 Length:1690 Species:Homo sapiens


Alignment Length:302 Identity:66/302 - (21%)
Similarity:104/302 - (34%) Gaps:85/302 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   357 QAGSE-----VSALLGRIPSAVGYQPTLGTDMGTMQERITSTRNGSITSVQAVYVPADDLSDPAP 416
            ||..|     :||.|.:..:    .|.|...:.:.|:   |..|..::||.:           :|
Human  1286 QAAREKTEKIISAELQKAAA----NPDLQGHLPSFQQ---SAFNRVVSSVSS-----------SP 1332

  Fly   417 AATFSHLDATTVLSRPIAELGIYPAVDPLD-SSSRILDPDVVGEEHYNVARAVQKT--------- 471
            ..|..:.|..|.....|.|...|...|... .||..|:|::..:|...:......|         
Human  1333 RQTMDYDDEETDSDEDIRETYGYDMKDTASVKSSSSLEPNLFCDEEIPIKSEEVVTHMWTAPSFC 1397

  Fly   472 -LQAYKSLQDIIAILGMDELSEEDKLTVARARKMQRFLSQPFQVAEIFTGHPGKLVPVEKCVEGF 535
             ..||.|     |.....:.|...:....::..:.|.|..|  |.|:   .||....:|:.:   
Human  1398 AEHAYSS-----ASKSCSQGSSTPRKQPRKSPLVPRSLEPP--VLEL---SPGAKAQLEELM--- 1449

  Fly   536 KRLLNGEYDDIPEIAFYMVGDAEEVLAKATQ-LAASMSGDAPPAK---AEAKKDEKKDTKP---- 592
                             ||||..||....|| :...:....||::   ....:|:..:.||    
Human  1450 -----------------MVGDLLEVSLDETQHIWRILQATHPPSEDRFLHIMEDDSMEEKPLKVK 1497

  Fly   593 -----EEGKKEEPPK-----GEDK---KEEAKDDKPKEPEKK 621
                 |:.:|.:..|     ||.|   ||..|.|||::.:.|
Human  1498 GKDSSEKKRKRKLEKVEQLFGEGKQKSKELKKMDKPRKKKLK 1539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATPsynbetaLNP_648836.2 PRK09280 103..568 CDD:236447 48/227 (21%)
ATP-synt_ab_N 106..173 CDD:280947
F1-ATPase_beta 175..454 CDD:238553 24/102 (24%)
ATP-synt_ab_C 462..571 CDD:278722 22/119 (18%)
KDM5ANP_001036068.1 JmjN 18..59 CDD:128818
ARID 85..170 CDD:198082
PHD1_KDM5A 295..343 CDD:277075
GSGFP motif. /evidence=ECO:0000250|UniProtKB:Q3UXZ9 419..423
JmjC 470..586 CDD:202224
zf-C5HC2 676..728 CDD:280996
PLU-1 741..1070 CDD:285609
PHD2_KDM5A 1163..1215 CDD:277079
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1327..1348 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1407..1433 3/25 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1490..1509 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1516..1543 10/24 (42%)
PHD3_KDM5A 1608..1659 CDD:277156
Interaction with LMO2. /evidence=ECO:0000269|PubMed:9129143 1623..1690
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0055
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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