DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATPsynbetaL and JARID2

DIOPT Version :9

Sequence 1:	NP_648836.2	Gene:	ATPsynbetaL / 39761	FlyBaseID:	FBgn0036568	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	XP_011512881.1	Gene:	JARID2 / 3720	HGNCID:	6196	Length:	1309	Species:	Homo sapiens

Alignment Length:	400	Identity:	91/400 - (22%)
Similarity:	147/400 - (36%)	Gaps:	101/400 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   271 HGGYSVFVGAGERTREGNDLY-HEMIES----------KVISLEDDSSKVVLVFGQMNEPPGARS 324
            |.|: ||.|:...|||...:. |:..|:          :..|..:.:|        .|.|..|.|
Human   283 HNGH-VFNGSSRSTREKEPVQKHKSKEATPAKEKHSDHRADSRREQAS--------ANHPAAAPS 338

  Fly   325 R-VVLTGLTIAEYFRDV--DGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLGTDMGTM 386
            . ....||....:...:  ..||:...:..:...|:    :|:|...:.||...:....:...|:
Human   339 TGSSAKGLAATHHHPPLHRSAQDLRKQVSKVNGVTR----MSSLGAGVTSAKKMREVRPSPSKTV 399

  Fly   387 QERITSTRNGSITSVQAVYVPADDL--SDPAPAATFSHL--------DATT---VLSRPIAELGI 438
            :...|.|: |::|..:|......|.  :...|::..:|.        :|.|   |||...|....
Human   400 KYTATVTK-GAVTYTKAKRELVKDTKPNHHKPSSAVNHTISGKTESSNAKTRKQVLSLGGASKST 463

  Fly   439 YPAVDPLDSSSRILDP-----DVVGEEHYNVARAVQKTLQAYKSLQDIIAILGMDELSEEDKLTV 498
            .|||:.|..|.| |:|     :|.|       |.:::.||..:.|::             .|..:
Human   464 GPAVNGLKVSGR-LNPKSCTKEVGG-------RQLREGLQLREGLRN-------------SKRRL 507

  Fly   499 ARARKMQRFLSQPFQV------AEIFTGHPGKLVPVEKCVEGFKRLLNGEY-DDIPEIAFYMVGD 556
            ..|.:.::..|.|.::      ||    .|||..|.|      :.||||.. .::||.:.
Human   508 EEAHQAEKPQSPPKKMKGAAGPAE----GPGKKAPAE------RGLLNGHVKKEVPERSL----- 557

  Fly   557 AEEVLAKATQLAASMSGDAPPAKAEAKKDEKKDT-------KPEEGKKEEPPKGEDKKE-EAKDD 613
             |....|......|..|.....||::...|.:.|       ||::..|.|  ||..|.. .|.|:
Human   558 -ERNRPKRATAGKSTPGRQAHGKADSASCENRSTSQPESVHKPQDSGKAE--KGGGKAGWAAMDE 619

  Fly   614 KP-KEPEKKD 622
            .| ..|..|:
Human   620 IPVLRPSAKE 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPsynbetaL	NP_648836.2	PRK09280	103..568	CDD:236447	73/335 (22%)
		ATP-synt_ab_N	106..173	CDD:280947
		F1-ATPase_beta	175..454	CDD:238553	47/209 (22%)
		ATP-synt_ab_C	462..571	CDD:278722	23/115 (20%)
JARID2	XP_011512881.1	JmjN	619..660	CDD:128818	3/10 (30%)
		BRIGHT	686..777	CDD:128777
		JmjC	979..1094	CDD:202224
		zf-C5HC2	1202..1255	CDD:280996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900