DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATPsynbetaL and Vha68-3

DIOPT Version :9

Sequence 1:	NP_648836.2	Gene:	ATPsynbetaL / 39761	FlyBaseID:	FBgn0036568	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_609595.1	Gene:	Vha68-3 / 34695	FlyBaseID:	FBgn0032464	Length:	743	Species:	Drosophila melanogaster

Alignment Length:	672	Identity:	160/672 - (23%)
Similarity:	257/672 - (38%)	Gaps:	163/672 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AKMAT----ACARIGLKMGPGTGGYRGNYLGNPVVFPRYLHASLSLWDD-KDKKKSGDECEPEPQ 65
            ||..|    ||.|...|..|.....:..   .||..|...|.:::..|. ||.::|.|:..
  Fly    46 AKKCTCPTCACQRNDHKSNPVPPPPQSR---KPVAEPESPHDTVNDEDSLKDLRRSTDQSH---- 103

  Fly    66 EVCKTDAELVKKKDEAEDECEEKKSDG---GGKKLESKGRKGVIHAVIGPVIDVYFEEEVPEVLN 127
                ..|.:..:|:|......|:..|.   ...:.|.:...|.|..|.|||:            |
  Fly   104 ----KSAHIALEKNEDSGFVIEQVVDTHKYSSDEEEEEATMGRIFGVSGPVV------------N 152

  Fly   128 ALQVQDAPIANLVLEVFHHLGNNIVR-------CVAMDSTEGLRRGQPVLDTGYPIRVAVGKAVL 185
            |.::..|.:..||......|...|:|       ....:.|.|:..|.||..||.|:.|.:|..::
  Fly   153 AEEMAGAAMYELVRVGHSQLVGEIIRLEGDMATIQVYEDTSGVSVGDPVYQTGKPLSVELGPGIM 217

  Fly   186 GRILNVVGDPIDDRGEVKSDFY-----------------------------------------SF 209
            |.|.:.:..|:....|:.:..|                                         |.
  Fly   218 GSIFDGIQRPLRSISELTNSIYVPKGIDTPSLPRNIAYEFTPGKLKIDALITGGDIYGSVFENSM 282

  Fly   210 IH-----------------------------------NEAPELTDLSVKP--------------E 225
            :|                                   :|..:.|.|.|.|              .
  Fly   283 MHDHRLILPPRTKGRIRWLAPPGNYCVDEVIVETEFNDEITKHTMLQVWPVRRCRPVEDKLPSNS 347

  Fly   226 ILVTGIKVIDLLAPYVKGGKIGLFGGAGVGKTVLIMELINNIAKSHGGYSVFVGAGERTREGNDL 290
            .|:||.:|:|...|.|:||...:.|..|.||||:...|..   .|:....::||.|||..|.:::
  Fly   348 PLLTGQRVLDAFFPCVQGGTTAIPGAFGCGKTVISQALSK---YSNSDVIIYVGCGERGNEMSEV 409

  Fly   291 YHEMIESKVI---SLEDDSSKVVLVFGQMNEPPGARSRVVLTGLTIAEYFRDVDGQDVLLFIDNI 352
            ..:..:.:|.   ::|....:..||....|.|..||...:.||:|::|||||: |..|.:..|:.
  Fly   410 LRDFPQLEVEVNGTMESIMKRTALVANTSNMPVAAREASIYTGITLSEYFRDM-GYHVSMMADST 473

  Fly   353 FRFTQAGSEVSALLGRIPSAVGYQPTLGTDMGTMQERI-------TSTRNGSITSVQAVYVPADD 410
            .|:.:|..|:|..|..:|:..||...||..:.:..||.       :..|.||::.|.||..|..|
  Fly   474 SRWAEALREISGRLAEMPADAGYPAYLGARLASFYERAGLVKCLGSPDREGSVSIVGAVSPPGGD 538

  Fly   411 LSDPAPAATFSHLDATTVLSRPIAELGIYPAVDPLDSSS---RILDP--DVVGEEHYNVARAVQK 470
            .|||..:||.|.:.....|.:.:|:...:|:|:.|.|.|   |.||.  :....|..::....:|
  Fly   539 FSDPVTSATLSIVQVFWGLDKKLAQRKHFPSVNWLQSYSKYMRTLDTYYEESNPEFTHLRAKAKK 603

  Fly   471 TLQAYKSLQDIIAILGMDELSEEDKLTVARARKMQ-RFLSQ----------PF-----QVAEIFT 519
            .||....|.:|:.::|...|:||||:|:..|:.:: .||.|          ||     .:..:.|
  Fly   604 VLQEEDDLAEIVQLVGKSSLNEEDKITLEVAKMLKDDFLQQNSYSQYDAYCPFFKTIGMLKNMMT 668

  Fly   520 GHPGKLVPVEKCVEGFKRLLNG 541
            .:...::.|:...:...|:..|
  Fly   669 FYDAAILSVQNTADNEARVTWG 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPsynbetaL	NP_648836.2	PRK09280	103..568	CDD:236447	137/567 (24%)
		ATP-synt_ab_N	106..173	CDD:280947	18/73 (25%)
		F1-ATPase_beta	175..454	CDD:238553	92/381 (24%)
		ATP-synt_ab_C	462..571	CDD:278722	22/96 (23%)
Vha68-3	NP_609595.1	V-ATPase_V1_A	141..729	CDD:273411	137/566 (24%)
		ATP-synt_ab_N	143..205	CDD:280947	18/73 (25%)
		V_A-ATPase_A	207..579	CDD:238554	90/375 (24%)
		ATP-synt_ab_C	597..738	CDD:278722	22/94 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454777
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840