DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATPsynbetaL and KDM6B

DIOPT Version :9

Sequence 1:	NP_648836.2	Gene:	ATPsynbetaL / 39761	FlyBaseID:	FBgn0036568	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_001073893.1	Gene:	KDM6B / 23135	HGNCID:	29012	Length:	1682	Species:	Homo sapiens

Alignment Length:	174	Identity:	37/174 - (21%)
Similarity:	56/174 - (32%)	Gaps:	57/174 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VSWAKMATACARIGLKMGPGTG--------GYRGNYLGNPVVFPRYLHASLSLWD--------DK 51
            |.|.:....|..|...:||.|.        .|..|.:.|.......:|.|   |:        |.
Human  1469 VHWVQATGWCNNIAWNVGPLTAYQYQLALERYEWNEVKNVKSIVPMIHVS---WNVARTVKISDP 1530

  Fly    52 DKKKSGDECEPEPQEVCKTDAELV----KK-------KDEAEDECEE----------KKSDGGGK 95
            |..|....|..:..:.|:...|.:    ||       |||....|.|          ..|:.|.:
Human  1531 DLFKMIKFCLLQSMKHCQVQRESLVRAGKKIAYQGRVKDEPAYYCNECDVEVFNILFVTSENGSR 1595

  Fly    96 -----------KLESKGRKGVIHAVIGPVIDVYFEEEVPEVLNA 128
                       :..|.|.:||:      |::.|..||:.:..:|
Human  1596 NTYLVHCEGCARRRSAGLQGVV------VLEQYRTEELAQAYDA 1633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPsynbetaL	NP_648836.2	PRK09280	103..568	CDD:236447	7/26 (27%)
		ATP-synt_ab_N	106..173	CDD:280947	5/23 (22%)
		F1-ATPase_beta	175..454	CDD:238553
		ATP-synt_ab_C	462..571	CDD:278722
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..88
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..680
		Mito_fiss_reg	<566..640	CDD:283069
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	704..807
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	822..1096
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1325
		JmjC	1343..1407	CDD:214721
		JmjC	1377..1485	CDD:202224	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900