DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATPsynbetaL and rbr-2

DIOPT Version :9

Sequence 1:	NP_648836.2	Gene:	ATPsynbetaL / 39761	FlyBaseID:	FBgn0036568	Length:	622	Species:	Drosophila melanogaster
Sequence 2:	NP_502032.2	Gene:	rbr-2 / 177985	WormBaseID:	WBGene00004319	Length:	1477	Species:	Caenorhabditis elegans

Alignment Length:	732	Identity:	139/732 - (18%)
Similarity:	227/732 - (31%)	Gaps:	268/732 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 GNPVVFPRYLHASLSLWDD------KDK-KKSGDECEPEPQEV----------CKTDAELVKKK- 78
            |.|..|...:.:..:|..:      |:| .|:.||.:.|.:|:          .:|:.|:...|
Worm   193 GVPSAFINLIRSHYNLHIEPFNRNLKEKAMKNDDESDDEMEELKHKYQHHHGTMRTEIEVPNDKT 257

  Fly    79 -DEAEDEC-----------EEKKSDG-------GGKKLESKGRKGVIHA---------------- 108
             :..||||           :.||:..       ..||..::|||....|
Worm   258 TEGGEDECPVSMQSGRRRSKNKKASSSRKTLGTSSKKNSTRGRKNKKKAEGDDDDDEDPMDQVFC 322

  Fly   109 ---------------------------VIGPVIDVYFEEEVPE----VLNALQVQDAPI------ 136
                                       ...||:|     ||||    ....::.:||.|
Worm   323 VACNEGKDEDLLLLCDIDGCNNGRHTYCCDPVLD-----EVPEGEWRCPKCIESEDAKIGLDWGF 382

  Fly   137 ----ANLVLEVFHHLGNNI------VRCVAMDSTEGLRRG--QPVLDTGYPIRVAVGKAVLGRIL 189
                ....|..|....|..      |:.|:..|.:.:.|.  :.|:....|:.|..|..:   |.
Worm   383 YDADTEYNLNSFTEFANKWKCDYFGVKDVSQVSCDAVERSFWKNVISHENPVSVKYGADL---IT 444

  Fly   190 NVVGDPI---DDRG-----EVKSDFYSFIHNEAPELTDLSVKPEILV----TGIKVIDLLAPYVK 242
            :.||...   :|:.     ::|..:.|...|    |.::.|..|.::    |||.  .::.|:|
Worm   445 SRVGSGFPRKEDKHTGPDLKLKQQYASHAWN----LNNMPVLRESVLSHFNTGIS--GMMVPWV- 502

  Fly   243 GGKIGLFGGAGVGKTVLIMELINNIAKSHGGYSV-FVGAGERTREGNDLYHEMIESKVISLEDDS 306
              .:|:........|           :.|..||| :...|||     .:::.:........||..
Worm   503 --YVGMCFSTFCWHT-----------EDHWTYSVNYNHFGER-----KIWYGVGGEDAEKFEDAL 549

  Fly   307 SKVVLVFGQMNEPPG--ARSRVVLTGLTIAEYFRDVDGQDVLLFIDNIFRFTQAGSEVSALLGRI 369
            .|:.         ||  .|.|.:...:|                       |.|...:...|| :
Worm   550 KKIA---------PGLTGRQRDLFHHMT-----------------------TAANPHLLRSLG-V 581

  Fly   370 PSAVGYQPTLGTDMGTMQERITSTRNGSITSVQAV-YVPADDLSDPAPAA-TFSHLDATTVLSRP 432
            |....:| ..|..:.|......:..|..:...:|| :.|.|.||...... ::|::....|.|..
Worm   582 PIHSVHQ-NAGEFVITFPRAYHAGFNEGLNFAEAVNFAPIDWLSKGRECVESYSNVRRYLVFSHD 645

  Fly   433 IAELGIYPAVDPLDSSSRILDPDVVGEEHYNVARAVQKTLQAYKSLQDIIAILGMDELSEEDKLT 497
            .....:..|:|.|..|..:       ..|..:.|..:|    .|.|::::|.||:..
Worm   646 ELLFKMVEAMDKLGISMSL-------ATHEELIRIYEK----QKMLRELLARLGVSN-------- 691

  Fly   498 VARARKMQRFLSQP---------------FQVAEIFTGHPGKLVPVEKCVEGFKRLLNG------ 541
                |:||:.:.:.               |..|.:...|. |:.    |||....|.|.
Worm   692 ----RQMQQVMFEKIPDEQRSCRFCKTTLFMCALVCNKHK-KMT----CVEHHDHLCNSCTTKDY 747

  Fly   542 ------EYDDIPEIAFYMVGDAEEVLAKATQLAASMSGDAPPAKAEAKKDEKKDTKPEEGKKEEP 600
                  |.|.:..:.        :.|.|.|            ......|:|..:...||||
Worm   748 RYQYRFELDQLNNMC--------DELGKRT------------VNYNGWKEESDEMLEEEGK---- 788

  Fly   601 PKGEDKKE---EAKDDK 614
            ||.|..:|   .||.:|
Worm   789 PKLERIEEFIDSAKQNK 805

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATPsynbetaL	NP_648836.2	PRK09280	103..568	CDD:236447	102/573 (18%)
		ATP-synt_ab_N	106..173	CDD:280947	19/131 (15%)
		F1-ATPase_beta	175..454	CDD:238553	57/295 (19%)
		ATP-synt_ab_C	462..571	CDD:278722	24/135 (18%)
rbr-2	NP_502032.2	JmjN	55..96	CDD:128818
		BRIGHT	122..214	CDD:128777	4/20 (20%)
		PHD_SF	321..368	CDD:304600	7/51 (14%)
		JmjC	501..617	CDD:202224	29/168 (17%)
		zf-C5HC2	709..761	CDD:280996	11/56 (20%)
		PLU-1	788..1130	CDD:285609	8/22 (36%)
		PHD	1208..1254	CDD:214584
		PHD3_KDM5A_like	1413..1463	CDD:277083
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900