Protein Alignment CG13074 and Dync2i2

DIOPT Version :10

• Sequence 1: NP_648835.1
• Gene: CG13074 / 39760
• FlyBaseID: FBgn0036567
• Length: 451
• Species: Drosophila melanogaster
• Sequence 2: NP_001008498.2
• Gene: Dync2i2 / 71820
• MGIID: 1919070
• Length: 537
• Species: Mus musculus
• Alignment Length: 442
• Identity: 88/442 - (19%)
• Similarity: 146/442 - (33%)
• Gaps: 128/442 - (28%)

  Fly    42 AATGTQEKLHVATQT-----EQRVVSSKDVEYDERALAKWLRQICPMVERELMNPTPLMEDLTMS 101
            |.:..|.:.|...|.     |:....:...:||...|..:||::..||.|||.|
Mouse    73 AESSAQARTHADAQVQTEAPEEPAAMAPVSQYDTLRLEAFLRRVEAMVIRELNN----------- 126

  Fly   102 QCRLEEKLQVYTYQKLIMGGAENSQGLAIWLCVHT------------------NNAPVLVATTVA 148
                  ..|.:.:....:...|..|.::   |:||                  |:...::|....
Mouse   127 ------NWQSHAFDGYEVNWTEQQQTVS---CLHTLVYPLAQGQGLHVTGISWNSTGSVLACAYG 182

  Fly   149 PHD--DWCEHVDQQLKLFV-----------PQRMSVGNLVIYTEAKTLPLKSCLRSLCTNPFNKT 200
            ..|  ||     ..||.:|           ||:.||          .:.:.|.:..|..:|...:
Mouse   183 RLDDGDW-----STLKSYVCTWNLDRQGLNPQQPSV----------VVEVPSAVMCLAFHPTQPS 232

  Fly   201 MFAGSTMDGELFIW---------LYEQARGSDSSVDIKQLYSVSSTQGAAVALDWPR---EHLLL 253
            ..||....||:.:|         |:......|:..|  .:|.|       :.|..||   ...:|
Mouse   233 HIAGGLYSGEVLVWDMSRPEDPLLWRTGLTDDTHTD--PVYQV-------LWLPEPRHSHRFQVL 288

  Fly   254 ACFANGSVRQW--------DLSRQMALDWEYTLPATVSSEP---------TAMVTLGLDD--FVV 299
            :...:|.|..|        .|::..||..:....:|...:|         |::.....|.  ||:
Mouse   289 SAATDGKVLLWRGSGAGQLRLTKGFALAVQQLPRSTKLKKPPRGETEVGVTSVAFSSFDSSLFVL 353

  Fly   300 GTNDGGVYRCWNTGRQTAAIKQIKLLALRR--------HRFMVSTLLRTEMEGNLFVLSCDLSGQ 356
            ||..|...:|.......|..:....:.||.        |...|.::..:....||| ||....|.
Mouse   354 GTEGGFPLKCSLASEVAALTRMPSSVPLRAPVQFTFSPHGGPVYSVSCSPFHRNLF-LSAGTDGH 417

  Fly   357 AFYHDMRLVDEDMAQLIVQIPLPFKNVIAC--SRDGNIIFCPAN-DGSLEYY 405
            ...:.|.     .||.:..:.|..|.:.|.  |....::|..|: :|.::.:
Mouse   418 VHLYSML-----QAQPLTSLQLSHKYLFAVRWSPVRPLVFAAASGEGDVQLF 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13074	NP_648835.1	None
Dync2i2	NP_001008498.2	WD40	50..515	CDD:441893	88/442 (20%)
		DYNLL2 binding. /evidence=ECO:0000250|UniProtKB:Q96EX3	80..93		2/12 (17%)
		DYNLRB1 binding. /evidence=ECO:0000250|UniProtKB:Q96EX3	107..132		10/41 (24%)
		WD40 repeat	165..211	CDD:293791	10/50 (20%)
		WD 1. /evidence=ECO:0000255	216..256		8/39 (21%)
		WD40 repeat	223..265	CDD:293791	8/41 (20%)
		WD 2. /evidence=ECO:0000255	265..309		10/52 (19%)
		WD40 repeat	271..312	CDD:293791	10/47 (21%)
		WD40 repeat	339..389	CDD:293791	11/49 (22%)
		WD 3. /evidence=ECO:0000255	391..431		11/45 (24%)
		WD40 repeat	396..433	CDD:293791	10/42 (24%)
		WD 4. /evidence=ECO:0000255	434..474		7/31 (23%)
		WD40 repeat	439..479	CDD:293791	5/26 (19%)
		WD 5. /evidence=ECO:0000255	481..521
		WD40 repeat	486..511	CDD:293791