DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13074 and dync2i2

DIOPT Version :9

Sequence 1:	NP_648835.1	Gene:	CG13074 / 39760	FlyBaseID:	FBgn0036567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	XP_012823678.1	Gene:	dync2i2 / 448417	XenbaseID:	XB-GENE-953027	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	442	Identity:	86/442 - (19%)
Similarity:	154/442 - (34%)	Gaps:	133/442 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 SQDAATGTQEKLHV---ATQTE----QRVVSSKDVE----YDERALAKWLRQICPMVERELMNPT 92
            |..|...:.:..||   .||||    ||.:   ||:    .|...|.::|:::..::.:|| |..
Frog    33 SLKAKEASNQACHVREMGTQTELNANQRTL---DVDLGPLLDYPDLGQFLKRVEGIMIKEL-NKN 93

  Fly    93 PLMEDLTMSQCRLEEKLQVYTYQKLIMGGAENSQGLAIWLCVHTNNAPVLVATTVAPHDDWCEHV 157
            .........:...||:.:..|                   |:|:...|              :.:
Frog    94 WKSHAFDGYEVNWEEQHEQVT-------------------CLHSLQYP--------------DAL 125

  Fly   158 DQQLKLFVPQRMSVGNLVIYTEAK------------------------------TLPLKSCLRSL 192
            :|||::......|.|:::..:..:                              .|.:.|.:..|
Frog   126 EQQLQVTSVSWNSTGSIIACSYGRFGDGDWSTEKSYVCTWNLDRRGFNANNPDTVLDVPSSVMCL 190

  Fly   193 CTNPFNKTMFAGSTMDGELFIWLYEQARGSDSSVDIKQLYSVSSTQGAAV-ALDWPRE------H 250
            ..:|...::.||...:|::.:|  :.:|..|..  |.:...|..|...|| .:.|.:|      |
Frog   191 AWHPSQPSLIAGGLFNGDVLVW--DTSRTDDPL--IGRTGHVGDTHTDAVYQVGWMQEKSQGHRH 251

  Fly   251 LLLACFANGSVRQWDLSRQ---MALDWEYTLPATVSSEPTAMVTLGLDD---------------- 296
            .:.:..::|.:..|.:.::   :.|| .:.|.|......|.:...|..|
Frog   252 QVFSVSSDGKILVWQMEKEGHLVLLD-GFALVAQQIPSNTKIHKPGRGDTAVGVTCLSYSHFDPS 315

  Fly   297 -FVVGTNDGGVYRCWNTGRQTAAIKQIKLLALRR--------HRFMVSTLLRTEMEGNLFVLSCD 352
             |:||...|.:.:|.::.:..|.|.....:.||.        |...|.::..:....||| ||..
Frog   316 LFIVGVEGGYLLKCSSSVQTLAPINMGSSVPLRAPAQFTFSPHGGPVYSVTCSPFHRNLF-LSAG 379

  Fly   353 LSGQAFYHDM----RLVDEDMAQ-LIVQI------PLPFKNVIACSRDGNII 393
            ..|.|..:.|    .||...::| .:..|      ||.|   .|.|.||.::
Frog   380 TDGHAHLYSMLQAKPLVSLQLSQKYLFSIRWSPVRPLVF---AAASGDGEVV 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13074	NP_648835.1	WD40 repeat	189..234	CDD:293791	9/44 (20%)
CG13074	NP_648835.1	WD40 repeat	242..275	CDD:293791	8/42 (19%)
dync2i2	XP_012823678.1	WD40 repeat	131..182	CDD:293791	2/50 (4%)
		WD40	184..481	CDD:392136	56/254 (22%)
		WD40 repeat	188..227	CDD:293791	9/42 (21%)
		WD40 repeat	236..297	CDD:293791	11/61 (18%)
		WD40 repeat	305..355	CDD:293791	9/49 (18%)
		WD40 repeat	362..399	CDD:293791	11/37 (30%)
		WD40 repeat	405..446	CDD:293791	8/27 (30%)
		WD40 repeat	452..477	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010