DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG13074 and Sdic3

DIOPT Version :9

Sequence 1:	NP_648835.1	Gene:	CG13074 / 39760	FlyBaseID:	FBgn0036567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001285482.2	Gene:	Sdic3 / 318231	FlyBaseID:	FBgn0052823	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	454	Identity:	79/454 - (17%)
Similarity:	146/454 - (32%)	Gaps:	154/454 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 DAATGTQEKLHVATQTEQRVVSSKDVEYDERALAKWLRQICPMVERELMNPTPLMEDLTMSQCRL 105
            |:.....|:.|..       :|...|.||||    |.:..|             :..:..|.
  Fly   166 DSEEANDERSHAR-------LSLNRVFYDER----WSKNRC-------------ITSMDWST--- 203

  Fly   106 EEKLQVYTYQKLIMGGAENSQGLAIWLCVHTNNAP---VLVATTVAPHDDWCEHVDQQLKLFVPQ 167
                   .:.:|::|...|::        .:.|.|   |:|..|             :.|...|:
  Fly   204 -------HFPELVVGSYHNNE--------ESPNEPDGVVMVWNT-------------KFKKSTPE 240

  Fly   168 RMSVGNLVIYTEAKTLPLKSCLRSLCTNPFNKTMFAGSTMDGELFIWLYEQARGSDSSVDIKQLY 232
                         .....:|.:.|.|...||..:..|.|..|::.:|        |:.|  ::..
  Fly   241 -------------DVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLW--------DNRV--QKRT 282

  Fly   233 SVSSTQGAAVALDWP----------REHLLLACFANGSVRQWDLSR----QMALDWEYTLPATVS 283
            .:..|..:|.|...|          ..|.:::..::|.:..|.|..    |..|:.:......::
  Fly   283 PIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIA 347

  Fly   284 SEPTAMVTLGLDDFVVGTNDGGVYRCWNTGRQTAAIKQIKLLALRRHRFMVSTLLRTEME----- 343
            ....|.....::..|:|:.||.||.....|.: :.:.::    ..||...: |.:.|...
  Fly   348 ITSMAFPANEINSLVMGSEDGYVYSASRHGLR-SGVNEV----YERHLGPI-TGISTHYNQLSPD 406

  Fly   344 -GNLFVLSCDLSGQAFYHDMRLVD-----------------EDMAQLIVQIP-LPFKNVIACSRD 389
             |:||:.|.             :|                 ||.:..::.:. .|....:..:.|
  Fly   407 FGHLFLTSS-------------IDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVD 458

  Fly   390 GNIIFCPANDGSLEYYRVSDGAHAHVKG-GLRGKGSLIRSSDNGRWLIAGLY---GDEFQIFYV 449
            |:        |.|:.:.::......:.. .:.|..:|.|.|    |..:||:   |||....||
  Fly   459 GS--------GRLDLWNLNQDTEVPIASIVVAGAPALNRVS----WTPSGLHVCIGDEAGKLYV 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13074	NP_648835.1	WD40 repeat	189..234	CDD:293791	10/44 (23%)
CG13074	NP_648835.1	WD40 repeat	242..275	CDD:293791	8/46 (17%)
Sdic3	NP_001285482.2	Dynein_IC2	23..51	CDD:288403
		NtpH	108..>178	CDD:225368	3/11 (27%)
		WD40	196..512	CDD:295369	68/400 (17%)
		WD40 repeat	196..245	CDD:293791	11/92 (12%)
		WD40	<224..523	CDD:225201	62/354 (18%)
		WD40 repeat	251..289	CDD:293791	11/47 (23%)
		WD40 repeat	298..337	CDD:293791	5/38 (13%)
		WD40 repeat	349..435	CDD:293791	17/104 (16%)
		WD40 repeat	441..479	CDD:293791	5/45 (11%)
		WD40 repeat	487..513	CDD:293791	11/28 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.110