DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13074 and Dync2i2

DIOPT Version :9

Sequence 1:	NP_648835.1	Gene:	CG13074 / 39760	FlyBaseID:	FBgn0036567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001005542.2	Gene:	Dync2i2 / 296618	RGDID:	1359465	Length:	537	Species:	Rattus norvegicus

Alignment Length:	453	Identity:	92/453 - (20%)
Similarity:	147/453 - (32%)	Gaps:	133/453 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 PPPSQDAATGT-----QEKLHVATQT-----EQRVVSSKDVEYDERALAKWLRQICPMVERELMN 90
            |...|.|...|     |.:.|...|.     |:....:...:||...||.:||::..||.|||.|
  Rat    62 PKSCQTAGIATAEASAQARTHADAQVQTEAPEEPAAVAPVSQYDTLRLAAFLRRVEAMVVRELNN 126

  Fly    91 PTPLMEDLTMSQCRLEEKLQVYTYQKLIMGGAENSQGLAIWLCVHT------------------N 137
                             ..|.:.:....:...|..|.::   |:||                  |
  Rat   127 -----------------NWQSHAFDGYEVNWTEQQQTVS---CLHTLGYPPAQGQGLHVTGISWN 171

  Fly   138 NAPVLVATTVAPHD--DWCEHVDQQLKLFV-----------PQRMSVGNLVIYTEAKTLPLKSCL 189
            ....::|......|  ||     ..||.:|           |.:.||          .:.:.|.:
  Rat   172 TTGSVLACAYGRLDDGDW-----GTLKSYVCTWNLDRQGLNPHQPSV----------VVEVPSAV 221

  Fly   190 RSLCTNPFNKTMFAGSTMDGELFIW---------LYEQARGSDSSVDIKQLYSVSSTQGAAVALD 245
            ..|..:|...:..||....||:.:|         |:......|:..|  .:|.|       :.|.
  Rat   222 MCLAFHPIQPSHIAGGLYSGEVLVWDMSRPEDPLLWRTGLTDDTHTD--PVYQV-------LWLP 277

  Fly   246 WPR---EHLLLACFANGSVRQW--------DLSRQMALDWEYTLPATVSSEP---------TAMV 290
            .||   ...:|:...:|.|..|        .||:..||..:....:|...:|         |::.
  Rat   278 EPRHSHRFQVLSAATDGRVLLWRGSGAGQLRLSKGFALAVQQLPRSTKLKKPPRGETEVGVTSVA 342

  Fly   291 TLGLDD--FVVGTNDGGVYRCWNTGRQTAAIKQIKLLALRR--------HRFMVSTLLRTEMEGN 345
            ....|.  ||:||..|...:|.......|..:....:.||.        |...|.::..:....|
  Rat   343 FSSFDSSLFVLGTEGGFPLKCSLAAEAAALTRMPSSVPLRAPVQFTFSPHGGPVYSVSCSPFHRN 407

  Fly   346 LFVLSCDLSGQAFYHDMRLVDEDMAQLIVQIPLPFKNVIAC--SRDGNIIFCPAN-DGSLEYY 405
            || ||....|....:.|.     .||.:..:.|..|.:.|.  |....::|..|: :|.::.:
  Rat   408 LF-LSAGTDGHVHLYSML-----QAQPLTSLQLSHKYLFAVRWSPVRPLVFAAASGEGDVQLF 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13074	NP_648835.1	WD40 repeat	189..234	CDD:293791	11/53 (21%)
CG13074	NP_648835.1	WD40 repeat	242..275	CDD:293791	11/43 (26%)
Dync2i2	NP_001005542.2	WD40	101..515	CDD:225201	84/414 (20%)
		WD40 repeat	165..211	CDD:293791	9/50 (18%)
		WD40	218..515	CDD:295369	55/262 (21%)
		WD40 repeat	223..265	CDD:293791	8/41 (20%)
		WD40 repeat	271..309	CDD:293791	9/44 (20%)
		WD40 repeat	339..389	CDD:293791	11/49 (22%)
		WD40 repeat	396..433	CDD:293791	10/42 (24%)
		WD40 repeat	439..479	CDD:293791	5/26 (19%)
		WD40 repeat	486..511	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010