DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG13074 and DYNC1I1

DIOPT Version :9

Sequence 1:NP_648835.1 Gene:CG13074 / 39760 FlyBaseID:FBgn0036567 Length:451 Species:Drosophila melanogaster
Sequence 2:NP_004402.1 Gene:DYNC1I1 / 1780 HGNCID:2963 Length:645 Species:Homo sapiens


Alignment Length:514 Identity:101/514 - (19%)
Similarity:182/514 - (35%) Gaps:162/514 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 EKQHALVDNCTGTDPPPPSQDAATGTQE--KLHVATQTEQRVVSSKD-VEYDERALAKWLRQICP 82
            |:...:|::..|.|....:||.....:|  ...:..:.:|:::.|:: :.:.:|.:.        
Human   183 EEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIR-------- 239

  Fly    83 MVERELMNPTPLMEDLTMSQCRLEEK-------------LQVY-----------------TYQKL 117
            ::||.|...:.:..|  .|...||||             .|.|                 .|.:|
Human   240 VIERALAEDSDIFFD--YSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPEL 302

  Fly   118 IMGGAENSQGLAIWLCVHTNNAPVLVATTVAPHDDWCEHVDQQLKLFVPQRMS-VGNLVIYTEAK 181
            ::....|::.                    |||:              |..:: |.|:..   .|
Human   303 MVASYNNNED--------------------APHE--------------PDGVALVWNMKF---KK 330

  Fly   182 TLP-----LKSCLRSLCTNPFNKTMFAGSTMDGELFIWLYEQARGS-------DSSVDIKQLYSV 234
            |.|     .:|.:.|:|...|:..:..|.|..|::.:|.....|.:       .::.....:|.|
Human   331 TTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCV 395

  Fly   235 S--STQGAAVALDWPREHLLLACFANGSVRQWDL----SRQMALDWEYTLPATVSSEPTAMVTLG 293
            :  .||.|         |.|:....:|.:..|.|    :.|.:::..|.....|:....|..|..
Human   396 NVVGTQNA---------HNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGD 451

  Fly   294 LDDFVVGTNDGGVYRCWNTGRQTAAIKQIKLLALRRHRFMVSTLLRTEME------GNLFVLSC- 351
            :::||||:.:|.||.....|.: |.|.::    ...|:..| |.:...|.      .:|||.|. 
Human   452 VNNFVVGSEEGTVYTACRHGSK-AGIGEV----FEGHQGPV-TGINCHMAVGPIDFSHLFVTSSF 510

  Fly   352 DLSGQAF--YHDMRLVD-EDMAQLIVQI------PLPFKNVIACSRDGNIIFCPANDGSLEYYRV 407
            |.:.:.:  .|:..|.. ||.|..:..:      |..|    ||. ||.        |.|:.:.:
Human   511 DWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALF----ACV-DGM--------GRLDLWNL 562

  Fly   408 S------------DGAHA--HVKGGLRGKGSLIRSSDNGRWL-----IAGLYGDEFQIF 447
            :            :||.|  .|:....||...:..|:...|:     :|..:.||:..|
Human   563 NNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWVYDVGELAVPHNDEWTRF 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13074NP_648835.1 WD40 repeat 189..234 CDD:293791 9/51 (18%)
WD40 repeat 242..275 CDD:293791 6/36 (17%)
DYNC1I1NP_004402.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..58
Interaction with DCTN1. /evidence=ECO:0000250 2..123
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..125
Dynein_IC2 147..173 CDD:371592
Interaction with DYNLT1. /evidence=ECO:0000269|PubMed:27502274 147..163
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 169..221 7/37 (19%)
WD40 283..606 CDD:392136 76/387 (20%)
WD 1 285..334 11/85 (13%)
WD40 repeat 291..337 CDD:293791 12/82 (15%)
WD 2 338..378 9/39 (23%)
WD40 repeat 346..385 CDD:293791 7/38 (18%)
WD 3 387..428 10/49 (20%)
WD40 repeat 393..434 CDD:293791 11/49 (22%)
WD 4 437..477 12/40 (30%)
WD40 repeat 442..481 CDD:293791 12/43 (28%)
WD 5 482..527 11/45 (24%)
WD40 repeat 488..529 CDD:293791 9/40 (23%)
WD 6 530..570 10/52 (19%)
WD40 repeat 535..573 CDD:293791 8/50 (16%)
WD 7 576..615 9/38 (24%)
WD40 repeat 581..607 CDD:293791 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1453532at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.010

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