DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13074 and Dync1i2

DIOPT Version :9

Sequence 1:	NP_648835.1	Gene:	CG13074 / 39760	FlyBaseID:	FBgn0036567	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001185801.1	Gene:	Dync1i2 / 13427	MGIID:	107750	Length:	655	Species:	Mus musculus

Alignment Length:	374	Identity:	72/374 - (19%)
Similarity:	131/374 - (35%)	Gaps:	111/374 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 VEFP---------------ATQPLEKQHALVDNCTGTDPPPPSQ------DAATGTQEKLHVATQ 55
            |:||               ..||.|.:....|..|...|..|.:      |....::...|..|:
Mouse   163 VDFPPREIVTYTKETQTPVTAQPKEDEEEEDDVATPKPPVEPEEEKTLKKDEENDSKAPPHELTE 227

  Fly    56 TE-QRVVSSKD--------VEYDERALAKWLRQICPMVERELMNPTPLMED----------LTMS 101
            .| |:::.|::        ....||||::.:........|:|       ||          |:::
Mouse   228 EEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDL-------EDKEGEIQAGAKLSLN 285

  Fly   102 QCRLEEKLQVYTYQKLIMGGAENSQGLAIWLCVHTNNAPVLVATTVAPHDDWCEHVDQQLKLFVP 166
            :...:|:   ::..:::.....:||...:.:..:.||..       |||:              |
Mouse   286 RQFFDER---WSKHRVVSCLDWSSQYPELLVASYNNNEE-------APHE--------------P 326

  Fly   167 QRMS-VGNLVIYTEAKTLP-----LKSCLRSLCTNPFNKTMFAGSTMDGELFIW-------LYEQ 218
            ..:: |.|:   ...||.|     .:|.:.|.....|:..:..|.|..|::.:|       ...|
Mouse   327 DGVALVWNM---KYKKTTPEYVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQ 388

  Fly   219 ARGSDSSVDIKQLYSVS--STQGAAVALDWPREHLLLACFANGSVRQWDL--------SRQMALD 273
            .....::.....:|.|:  .||.|         |.|::...:|.:..|.|        |.::...
Mouse   389 RTPLSAAAHTHPVYCVNVVGTQNA---------HNLISISTDGKICSWSLDMLSHPQDSMELVHK 444

  Fly   274 WEYTLPATVSSEPTAMVTLGLDDFVVGTNDGGVYRCWNTGRQTAAIKQI 322
            ....:..|..|.|...|    ::||||:.:|.||.....|.: |.|.::
Mouse   445 QSKAVAVTSMSFPVGDV----NNFVVGSEEGSVYTACRHGSK-AGISEM 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13074	NP_648835.1	WD40 repeat	189..234	CDD:293791	8/51 (16%)
CG13074	NP_648835.1	WD40 repeat	242..275	CDD:293791	6/40 (15%)
Dync1i2	NP_001185801.1	Dynein_IC2	152..180	CDD:288403	3/16 (19%)
		WD40 repeat	299..348	CDD:293791	13/72 (18%)
		WD40	346..>616	CDD:225201	33/157 (21%)
		WD40 repeat	356..394	CDD:293791	6/37 (16%)
		WD40	397..>622	CDD:295369	25/106 (24%)
		WD40 repeat	402..443	CDD:293791	11/49 (22%)
		WD40 repeat	451..498	CDD:293791	14/43 (33%)
		WD40 repeat	506..538	CDD:293791
		WD40 repeat	544..582	CDD:293791
		WD40 repeat	590..616	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010