DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and GEF1

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_012574.1	Gene:	GEF1 / 853497	SGDID:	S000003801	Length:	779	Species:	Saccharomyces cerevisiae

Alignment Length:	802	Identity:	259/802 - (32%)
Similarity:	407/802 - (50%)	Gaps:	126/802 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 HVPTHSAFGDPMDGALSFYGSSDVQD-----DIPGIGQYEDFHTI------------DWQRDIAR 178
            :||.:...||          ..||.|     :||....::.|.||            |..|:...
Yeast     5 YVPINQPIGD----------GEDVIDTNRFTNIPETQNFDQFVTIDKIAEENRPLSVDSDREFLN 59

  Fly   179 DRMRHRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPA 243
            .:.||      .::.:||..|..|...|       ..|..||:||.:.:....:.:.|.|.|...
Yeast    60 SKYRH------YREVIWDRAKTFITLSS-------TAIVIGCIAGFLQVFTETLVNWKTGHCQRN 111

  Fly   244 FWFNREQCCYPAKQSVFEEGN---------CST---WKTWPEIFGLDRNGTGPYIVAYIWYVLWA 296
            :..|:..||......|....|         |..   |..|       :....|:|:    ::|.:
Yeast   112 WLLNKSFCCNGVVNEVTSTSNLLLKRQEFECEAQGLWIAW-------KGHVSPFII----FMLLS 165

  Fly   297 LLFASLSASLVRMFAPYACGSGIPEIKTILSGF-IIRGYLGKWTLLIKSVGLMLSVSAGLTLGKE 360
            :|||.:|..||:..||.|.||||.|||..:||| ..:.:||..||:||||.|.|::|:||::|||
Yeast   166 VLFALISTLLVKYVAPMATGSGISEIKVWVSGFEYNKEFLGFLTLVIKSVALPLAISSGLSVGKE 230

  Fly   361 GPMVHIASCIGNIFSHVFPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEV--SYYFP 423
            ||.||.|:|.|.:.:....:.....:.:.|.::||:.|||:||||||||||||.|||:  :..|.
Yeast   231 GPSVHYATCCGYLLTKWLLRDTLTYSSQYEYITAASGAGVAVAFGAPIGGVLFGLEEIASANRFN 295

  Fly   424 LKTLWRSFFCALIAAFVLRSLTPFGNEHSVLFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKA 488
            ..|||:|::.||:|...|:.:.||.|...:||.|.|::.|...|:..|:.|||.||:.|.:..|.
Yeast   296 SSTLWKSYYVALVAITTLKYIDPFRNGRVILFNVTYDRDWKVQEIPIFIALGIFGGLYGKYISKW 360

  Fly   489 NLWWCRYRKFSKLGQYPVMEVLFVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNP---- 549
            |:.:..:||. .|..:||.||||:..:||:|.|.|.|.:::|.|.:.:|..:|...|.|:.
Yeast   361 NINFIHFRKM-YLSSWPVQEVLFLATLTALISYFNEFLKLDMTESMGILFHECVKNDNTSTFSHR 424

  Fly   550 LCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAI 614
            ||.....  |....|::       :::|   |....:::..|.:.::|.:||||:|:||:.:||.
Yeast   425 LCQLDEN--THAFEFLK-------IFTS---LCFATVIRALLVVVSYGARVPAGIFVPSMAVGAT 477

  Fly   615 MGRIVGIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTG 679
            .||.|.:.||:| .|.|::            ||||.||.:||||.|.|:|.:|:::|||||||||
Yeast   478 FGRAVSLLVERF-ISGPSV------------ITPGAYAFLGAAATLSGITNLTLTVVVIMFELTG 529

  Fly   680 GVRYIVPLMAAAMASKWVGDALG-RQGIYDAHIALNGYPFL-DSKEEFAHTTL----AADVMQPK 738
            ...||:|||.....::.:....| ..||.|..|.:||:|:| |.::|....||    |..:|..|
Yeast   530 AFMYIIPLMIVVAITRIILSTSGISGGIADQMIMVNGFPYLEDEQDEEEEETLEKYTAEQLMSSK 594

  Fly   739 R---NETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRE----NQYLVGFVLRRDLNLAIGNAK 796
            .   |||:.:...:|:..|..    .|...:|:|:....:    .:..:|:||:|.|     .:|
Yeast   595 LITINETIYLSELESLLYDSA----SEYSVHGFPITKDEDKFEKEKRCIGYVLKRHL-----ASK 650

  Fly   797 RLIEGISS----SSIVLFTSSQPIQNLGPQP--LKLKKILDMAPITVTDQTPMETVVDMFRKLGL 855
            .:::.::|    :::|.|..|.  :.||.:.  :..|.|::.:||:|....|:..:..||::||.
Yeast   651 IMMQSVNSTKAQTTLVYFNKSN--EELGHRENCIGFKDIMNESPISVKKAVPVTLLFRMFKELGC 713

  Fly   856 RQTLVTHNGRLLGVITKKDVLR 877
            :..:|..:|.|.|::|.||:||
Yeast   714 KTIIVEESGILKGLVTAKDILR 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	191/523 (37%)
		Voltage_CLC	298..699	CDD:279048	164/407 (40%)
		CBS	738..876	CDD:223591	38/150 (25%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	38/147 (26%)
GEF1	NP_012574.1	ClC_3_like	83..569	CDD:239656	190/522 (36%)
		CBS_pair_voltage-gated_CLC_euk_bac	586..736	CDD:341367	42/161 (26%)
		CBS repeat	592..687	CDD:341367	22/105 (21%)
		CBS repeat	693..735	CDD:341367	14/41 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	272	1.000	Domainoid score	I279
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20435
Inparanoid	1	1.050	352	1.000	Inparanoid score	I389
Isobase	1	0.950	-	0	Normalized mean entropy	S1170
OMA	1	1.010	-	-		QHG55339
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		oto99559
orthoMCL	1	0.900	-	-		OOG6_100336
Panther	1	1.100	-	-	O	PTHR45711
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1878
SonicParanoid	1	1.000	-	-		X829
TreeFam	1	0.960	-	-
	15	14.810