DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and Clcn3

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_038950796.1	Gene:	Clcn3 / 84360	RGDID:	621219	Length:	866	Species:	Rattus norvegicus

Alignment Length:	834	Identity:	481/834 - (57%)
Similarity:	610/834 - (73%)	Gaps:	56/834 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SLTAAGTDDEDMIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNHHNQ 125
            |:|:| :.||:::|               |.|:...:.   .:|.|...|    |....|.|:.
  Rat    18 SITSA-SSDEELLD---------------GAGAIMDFQ---TSEDDNLLD----GDTAAGTHYT- 58

  Fly   126 RTMHQHVPTHSAFGDPMDGALSFYGSS---DVQDD-IPGIGQYEDFHTIDWQRDIARDRMRHRYI 186
                            |....|...|:   |:.|: |||:|.|:|||||||.|:..:||.|||.|
  Rat    59 ----------------MTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRI 107

  Fly   187 VKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQC 251
            ..|:::|.|::.|...||.||||.|.|.|:|:|.:||::||.|.||:|||.|||..|.|:|.|||
  Rat   108 NSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQC 172

  Fly   252 CYPAKQSVFEE-GNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYAC 315
            |:.:.::.||| ..|..||||.|:......|.|.||:.||.|:.|||.||.|:.|||::||||||
  Rat   173 CWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYAC 237

  Fly   316 GSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPK 380
            |||||||||||||||||||||||||:||::.|:|:|::||:||||||:||:|.|.|||||::|||
  Rat   238 GSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPK 302

  Fly   381 YGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLT 445
            |..|||||||:||||:||||||||||||||||||||||||||||||||||||.||:|||||||:.
  Rat   303 YSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367

  Fly   446 PFGNEHSVLFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVL 510
            ||||...|||:|||:.||..|||.||:.||:.||:.|.|||:||:.|||.||.:|.|:|||:||:
  Rat   368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVI 432

  Fly   511 FVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKR-MNITSGNSFIEVTEPGPGV 574
            .|..:||:|.:|||:||:|.:|||..|.:.|.|.: ::.||||:. ||.:.....|.....|.||
  Rat   433 IVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLE-SSSLCDYRNDMNASKIVDDIPDRPAGVGV 496

  Fly   575 YSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGE 639
            ||:||.|.|..|.|:.:|:||||:|||:||||||:.:|||.||||||.|||.|| |.:.||...|
  Rat   497 YSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAY-YHHDWFIFKE 560

  Fly   640 CAD--SNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALG 702
            ..:  ::.|||||||:|||||.||||||||||||||:||||||:.||||||||.|.|||||||.|
  Rat   561 WCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFG 625

  Fly   703 RQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDVENLLKETEHN 766
            |:|||:|||.||||||||:||||.|||||||||:|:|:: .|.|:|||:|||||:||::.||.:|
  Rat   626 REGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYN 690

  Fly   767 GYPVVVSRENQYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLF---TSSQPIQNLGPQPLKLKK 828
            |:||::|:|:|.||||.|||||.:||.:|::..||:..||.|.|   |.|.|.::  |:||||:.
  Rat   691 GFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGVVGSSRVCFAQHTPSLPAES--PRPLKLRS 753

  Fly   829 ILDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQM 882
            ||||:|.||||.||||.|||:||||||||.||||||.:||:||||::|.|::|:
  Rat   754 ILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKNILEHLEQL 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	327/507 (64%)
		Voltage_CLC	298..699	CDD:279048	269/403 (67%)
		CBS	738..876	CDD:223591	84/141 (60%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	84/140 (60%)
Clcn3	XP_038950796.1	ClC_3_like	136..642	CDD:239656	327/507 (64%)
		CBS_pair_voltage-gated_CLC_euk_bac	653..803	CDD:341367	92/151 (61%)
		CBS repeat	659..754	CDD:341367	49/96 (51%)
		CBS repeat	760..802	CDD:341367	31/41 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348878
Domainoid	1	1.000	546	1.000	Domainoid score	I251
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20435
Inparanoid	1	1.050	964	1.000	Inparanoid score	I310
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D116173at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		otm45379
orthoMCL	1	0.900	-	-		OOG6_100336
Panther	1	1.100	-	-	O	PTHR45711
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810