DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and CLC-C

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_199800.1	Gene:	CLC-C / 835052	AraportID:	AT5G49890	Length:	779	Species:	Arabidopsis thaliana

Alignment Length:	888	Identity:	234/888 - (26%)
Similarity:	368/888 - (41%)	Gaps:	254/888 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 GNHHNQR----TMHQHVPTHSAFGDPMDGALSF------YGSSDVQDDIPGIG---------QYE 165
            |:||:..    .:|......|...|  ||::.|      ....:....|..:|         .||
plant     7 GDHHDIEVEGGALHGFERKISGILD--DGSVGFRQPLLARNRKNTTSQIAIVGANTCPIESLDYE 69

  Fly   166 ----DFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVD 226
                ||...||     |.|       ||.:...:..:|        |....|:|:|.|.|..:.:
plant    70 IFENDFFKQDW-----RSR-------KKIEILQYTFLK--------WALAFLIGLATGLVGFLNN 114

  Fly   227 IGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYIW 291
            :|...::..|                      :...||....:              .|..|:..
plant   115 LGVENIAGFK----------------------LLLIGNLMLKE--------------KYFQAFFA 143

  Fly   292 YVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLT 356
            :....|:.|:.:|||....||.|.||||||:|..|:|......|...||.:|..|.:..|:||..
plant   144 FAGCNLILATAAASLCAFIAPAAAGSGIPEVKAYLNGIDAYSILAPSTLFVKIFGSIFGVAAGFV 208

  Fly   357 LGKEGPMVHIASCIGNIFSH----------VFPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGV 411
            :||||||||..:||.|:...          .:.::.:|:..:|::::..|||||:.||.||:|||
plant   209 VGKEGPMVHTGACIANLLGQGGSKKYRLTWKWLRFFKNDRDRRDLITCGAAAGVAAAFRAPVGGV 273

  Fly   412 LFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTP---------FGNEHSVLFFVE-----YNKP 462
            ||:|||.:.::....|||:||...:.|.|||||..         ||....::|.|.     |:.|
plant   274 LFALEEAASWWRNALLWRTFFTTAVVAVVLRSLIEFCRSGRCGLFGKGGLIMFDVNSGPVLYSTP 338

  Fly   463 WIFFELIPFVFLGIMGGVIGTFFIKANLWWCRY------RKFSKLGQ----YPVMEVLFVTLVTA 517
                :|:..||||::|||:|:.:        .|      |.:|.:.:    :.:|.|:.|:::::
plant   339 ----DLLAIVFLGVIGGVLGSLY--------NYLVDKVLRTYSIINEKGPRFKIMLVMAVSILSS 391

  Fly   518 IICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSG-------NSFIEVTEPGPGVY 575
            ...:..|:            :|:|:|       |.   :.|..|       :|..:..:..|..|
plant   392 CCAFGLPW------------LSQCTP-------CP---IGIEEGKCPSVGRSSIYKSFQCPPNHY 434

  Fly   576 SSIWLLMLT--------------------------FILKLALTIFTFGMKVPAGLFIPSLLLGAI 614
            :.:..|:|.                          |:....|.|.|:|:.:|:|||||.:|.||.
plant   435 NDLSSLLLNTNDDAIRNLFTSRSENEFHISTLAIFFVAVYCLGIITYGIAIPSGLFIPVILAGAS 499

  Fly   615 MGRIVGIGVEQFAYSYPNIWFFTGECADSNLITP------GLYAVVGAAAVLGGVTRMTVSLVVI 673
            .||:||                       .|:.|      ||::::|||:.|||..||||||.||
plant   500 YGRLVG-----------------------RLLGPVSQLDVGLFSLLGAASFLGGTMRMTVSLCVI 541

  Fly   674 MFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFL-DSKEEFAHTTLAADVMQP 737
            :.|||..:..:..:|...:.||.|.|...| |:||..:.:.|.|:: |..|.:....:|.||:..
plant   542 LLELTNNLLMLPLVMLVLLISKTVADCFNR-GVYDQIVTMKGLPYMEDHAEPYMRNLVAKDVVSG 605

  Fly   738 -----KRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVS---RENQYLVGFVLRRDLNLAIGN 794
                 .|.|.:.||.|          .||.|.|||:||:..   .|...|.|..||..|.:.:..
plant   606 ALISFSRVEKVGVIWQ----------ALKMTRHNGFPVIDEPPFTEASELCGIALRSHLLVLLQG 660

  Fly   795 AKRLIEGISSSSIVL------------FTSSQPIQNLGPQPLKLKKILDMAPITVTD-QTPMETV 846
            .|...:..:..|.:|            ......|::|.....:::..:|:.|||.|. .|.:||:
plant   661 KKFSKQRTTFGSQILRSCKARDFGKAGLGKGLKIEDLDLSEEEMEMYVDLHPITNTSPYTVLETL 725

  Fly   847 -----VDMFRKLGLRQTLVTHN--GR--LLGVITKKDVL-RHV 879
                 ..:||:||||...|...  ||  ::|::|:.|.: .||
plant   726 SLAKAAILFRQLGLRHLCVVPKTPGRPPIVGILTRHDFMPEHV 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	159/576 (28%)
		Voltage_CLC	298..699	CDD:279048	141/473 (30%)
		CBS	738..876	CDD:223591	44/162 (27%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	43/162 (27%)
CLC-C	NP_199800.1	ClC_6_like	64..586	CDD:239657	172/635 (27%)
		CBS_pair_voltage-gated_CLC_euk_bac	599..766	CDD:341367	47/176 (27%)
		CBS repeat	604..713	CDD:341367	25/118 (21%)
		CBS repeat	719..765	CDD:341367	15/45 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770