DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and CLC-A

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_198905.1	Gene:	CLC-A / 834090	AraportID:	AT5G40890	Length:	775	Species:	Arabidopsis thaliana

Alignment Length:	885	Identity:	233/885 - (26%)
Similarity:	371/885 - (41%)	Gaps:	242/885 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 SSSGYHRETATESDTERDFGHSGGNGGGNHHNQRTMHQHVPTHSAFGDPMDGA-LSFYGSSDVQD 156
            |:|.|:.|...| |.|           .|..||..:.:| .|.|:....:.|| :|...|.|
plant    10 SNSNYNGEEEGE-DPE-----------NNTLNQPLLKRH-RTLSSTPLALVGAKVSHIESLD--- 58

  Fly   157 DIPGIGQYE----DFHTIDWQRDIARDRMR-HRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGI 216
                   ||    |....||:   :|.:.: .:||..|                  |....|||:
plant    59 -------YEINENDLFKHDWR---SRSKAQVFQYIFLK------------------WTLACLVGL 95

  Fly   217 AAGCVAGMVDIGASWMSDLK-----HGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWPEIFG 276
            ..|.:|.::::....::..|     :.|....||         ....||...|
plant    96 FTGLIATLINLAVENIAGYKLLAVGYYIAQDRFW---------TGLMVFTGAN------------ 139

  Fly   277 LDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLL 341
                 .|..:||.:               ||..|||.|.|.||||||..|:|.......|..|::
plant   140 -----LGLTLVATV---------------LVVYFAPTAAGPGIPEIKAYLNGIDTPNMFGFTTMM 184

  Fly   342 IKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFP----------KYGRNEAKKREILSAAA 396
            :|.||.:.:|:|||.||||||:|||.|||.::.....|          :|..|:..:|::::..:
plant   185 VKIVGSIGAVAAGLDLGKEGPLVHIGSCIASLLGQGGPDNHRIKWRWLRYFNNDRDRRDLITCGS 249

  Fly   397 AAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTP---------FGNEHS 452
            |:||..||.:|:|||||:||||:.::....|||:||...:...|||:...         ||:...
plant   250 ASGVCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLRAFIEICNSGKCGLFGSGGL 314

  Fly   453 VLFFVEY-NKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQ----YPVMEVLFV 512
            ::|.|.: ...:...::||...:|:.||::|:.:  .:|.....|.::.:.|    :.|:..|.|
plant   315 IMFDVSHVEVRYHAADIIPVTLIGVFGGILGSLY--NHLLHKVLRLYNLINQKGKIHKVLLSLGV 377

  Fly   513 TLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVT-NPLC-------DYKRMNITSG-------- 561
            :|.|::..:..||            :::|.|.|.: :.:|       ::|:.|..:|
plant   378 SLFTSVCLFGLPF------------LAECKPCDPSIDEICPTNGRSGNFKQFNCPNGYYNDLSTL 430

  Fly   562 ----------NSFIEVTEPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMG 616
                      |.|...| |......|:|:.   |.|...|.:.|||:..|:|||:|.:|:|:..|
plant   431 LLTTNDDAVRNIFSSNT-PNEFGMVSLWIF---FGLYCILGLITFGIATPSGLFLPIILMGSAYG 491

  Fly   617 RIVGIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGV 681
            |::|..:.    ||.|             |..|||||:|||:::.|..||||||.||..|||..:
plant   492 RMLGTAMG----SYTN-------------IDQGLYAVLGAASLMAGSMRMTVSLCVIFLELTNNL 539

  Fly   682 RYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEE--FAHTTLAA--DVMQPKRNET 742
            ..:...|...:.:|.|||:. ...||:..:.|.|.|||::..|  ..:.|:..  |...|.  .|
plant   540 LLLPITMFVLLIAKTVGDSF-NLSIYEIILHLKGLPFLEANPEPWMRNLTVGELNDAKPPV--VT 601

  Fly   743 LNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQ---YLVGFVLRRDLNLAIG-----NAKRLI 799
            ||.:.:    |.::.::|:.|.||.:||:...:..   .|.|.:||..|...:.     |.||..
plant   602 LNGVEK----VANIVDVLRNTTHNAFPVLDGADQNTGTELHGLILRAHLVKVLKKRWFLNEKRRT 662

  Fly   800 E-----------------------GISSSSIVLFTSSQPIQNLGPQPLKLKKILDMAPITVTDQT 841
            |                       .|:||.:.|:....|:.|             ..|.||....
plant   663 EEWEVREKFTPVELAEREDNFDDVAITSSEMQLYVDLHPLTN-------------TTPYTVVQSM 714

  Fly   842 PMETVVDMFRKLGLRQTLVTHN------GRLLGVITKKDV 875
            .:...:.:||.:|||..||...      ..::|::|::|:
plant   715 SVAKALVLFRSVGLRHLLVVPKIQASGMSPVIGILTRQDL 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	159/558 (28%)
		Voltage_CLC	298..699	CDD:279048	139/450 (31%)
		CBS	738..876	CDD:223591	38/175 (22%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	38/172 (22%)
CLC-A	NP_198905.1	ClC_6_like	55..576	CDD:239657	173/628 (28%)
CLC-A	NP_198905.1	CBS_pair_voltage-gated_CLC_euk_bac	596..757	CDD:341367	39/178 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.770