DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and AT5G33280

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_198313.2	Gene:	AT5G33280 / 833300	AraportID:	AT5G33280	Length:	765	Species:	Arabidopsis thaliana

Alignment Length:	679	Identity:	194/679 - (28%)
Similarity:	321/679 - (47%)	Gaps:	128/679 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 GPYIVAYIWYVLWALLFASLSASLVRMF-APYACGSGIPEIKTILSG------FIIRGYLGKWTL 340
            |.:.:.::.:.:..|:. :|.||::..| ||.|.||||||:|..|:|      |.:|      ||
plant   110 GRFAMGFVVFSVTNLIL-TLFASVITAFVAPAAAGSGIPEVKAYLNGVDAPEIFSLR------TL 167

  Fly   341 LIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPK----------YGRNEAKKREILSAA 395
            :||.:|.:.:|||.|.:||.|||||..:|:.:|......|          :.:|:..:|::::..
plant   168 IIKIIGNISAVSASLLIGKAGPMVHTGACVASILGQGGSKRYRLTWRWLRFFKNDRDRRDLVTCG 232

  Fly   396 AAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTP---------FGNEH 451
            ||||::.:|.||:|||||:|||:|.::....|||.||...:.|.|||:|..         ||...
plant   233 AAAGIAASFRAPVGGVLFALEEMSSWWRSALLWRIFFSTAVVAIVLRALIDVCLSGKCGLFGKGG 297

  Fly   452 SVLFFV-EYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVLFVTLV 515
            .::|.| ..|..:...:::|.:.||::||::|:.:        .:.....|..|..:....||..
plant   298 LIMFDVYSENASYHLGDVLPVLLLGVVGGILGSLY--------NFLLDKVLRAYNYIYEKGVTWK 354

  Fly   516 TAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSI-- 578
            ..:.|..:.||...:..|.||...:..|.|.........|    ||| |.:...| ||.|:.:
plant   355 ILLACAISIFTSCLLFGLPFLASCQPCPVDALEECPTIGR----SGN-FKKYQCP-PGHYNDLAS 413

  Fly   579 ------------------------WLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIV 619
                                    :.:::.|:....|:||::|:..|||||:|.::.||..||.|
plant   414 LIFNTNDDAIKNLFSKNTDFEFHYFSVLVFFVTCFFLSIFSYGIVAPAGLFVPVIVTGASYGRFV 478

  Fly   620 GIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYI 684
            |:              ..|  ::||| ..||:||:|||:.|||..|||||..||:.|||..:..:
plant   479 GM--------------LLG--SNSNL-NHGLFAVLGAASFLGGTMRMTVSTCVILLELTNNLLLL 526

  Fly   685 VPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDS-KEEFAHTTLAADVMQPKRNETLNVITQ 748
            ..:|...:.||.|.|.. ...||:..:.|.|:|:|.| .|.:....|..||:.... :..|.|.:
plant   527 PMMMVVLLISKTVADGF-NANIYNLIMKLKGFPYLYSHAEPYMRQLLVGDVVTGPL-QVFNGIEK 589

  Fly   749 DSMTVDDVENLLKETEHNGYPVVVS---RENQYLVGFVLRRDLNLAIGNAKRLI----EGISSSS 806
                |:.:.::||.|.|||:|||..   .....|.|.:||..:...:  .||:.    ....|::
plant   590 ----VETIVHVLKTTNHNGFPVVDGPPLAAAPVLHGLILRAHILTLL--KKRVFMPSPVACDSNT 648

  Fly   807 IVLFTS----------SQPIQNLGPQPLKLKKILDM------APITVTDQTPMETVVDMFRKLGL 855
            :..|.:          |..|:::.....:|...||:      :|.||.:...:...:.:||::|:
plant   649 LSQFKAEEFAKKGSGRSDKIEDVELSEEELNMYLDLHPFSNASPYTVVETMSLAKALILFREVGI 713

  Fly   856 RQTLV----THNGRLLGVITKKDVL-RHV 879
            |..||    ::...::|::|:.|.: .|:
plant   714 RHLLVIPKTSNRPPVVGILTRHDFMPEHI 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	150/488 (31%)
		Voltage_CLC	298..699	CDD:279048	142/453 (31%)
		CBS	738..876	CDD:223591	37/164 (23%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	37/164 (23%)
AT5G33280	NP_198313.2	Voltage_gated_ClC	39..561	CDD:295552	150/489 (31%)
		Voltage_CLC	125..541	CDD:279048	142/453 (31%)
		CBS_pair_EriC_assoc_euk_bac	580..738	CDD:239964	37/164 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770