DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and CLC-D

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_197996.1	Gene:	CLC-D / 832693	AraportID:	AT5G26240	Length:	792	Species:	Arabidopsis thaliana

Alignment Length:	822	Identity:	226/822 - (27%)
Similarity:	373/822 - (45%)	Gaps:	200/822 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 DDIPGIGQYED----FHTIDWQ--RDIA-RDRMRHR-------YIVKKRQDSLWDLIKGSIDAGS 206
            |||..:..:.|    .:::|::  .:.| |:...||       |:..|
plant    29 DDITLLNSHRDGDGGVNSLDYEVIENYAYREEQAHRGKLYVGYYVAVK----------------- 76

  Fly   207 GWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTW 271
             |...||:||..|..|..:::...                                 |.:.|| :
plant    77 -WFFSLLIGIGTGLAAVFINLSVE---------------------------------NFAGWK-F 106

  Fly   272 PEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLG 336
            ...|.:.:..   |...:|.|:|..|:....||.::..|||.|.||||||||..|:|..|.|.|.
plant   107 ALTFAIIQKS---YFAGFIVYLLINLVLVFSSAYIITQFAPAAAGSGIPEIKGYLNGIDIPGTLL 168

  Fly   337 KWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFS-------HV---FPKYGRNEAKKREI 391
            ..||:.|..|.:.||..||.||||||:||..:||.::..       |:   :|:..:::..:|::
plant   169 FRTLIGKIFGSIGSVGGGLALGKEGPLVHTGACIASLLGQGGSTKYHLNSRWPQLFKSDRDRRDL 233

  Fly   392 LSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLT---------PF 447
            ::...||||:.||.||:|||||:||||:.::..:.:||.||.:.|.|.|:|:..         .|
plant   234 VTCGCAAGVAAAFRAPVGGVLFALEEVTSWWRSQLMWRVFFTSAIVAVVVRTAMGWCKSGICGHF 298

  Fly   448 GNEHSVLFFV-EYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLW---WCRYRKFSKLGQYPVME 508
            |....:::.| :....:.|.||:|...:|::||::|..|.:..|:   |.|.....|..:..::|
plant   299 GGGGFIIWDVSDGQDDYYFKELLPMAVIGVIGGLLGALFNQLTLYMTSWRRNSLHKKGNRVKIIE 363

  Fly   509 VLFVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPG 573
            ...::.:|:.|.:..|            |:.||||...:.|            :|.||...| ||
plant   364 ACIISCITSAISFGLP------------LLRKCSPCPESVP------------DSGIECPRP-PG 403

  Fly   574 VY-----------------SSIWL----------------------LMLTFI-LKLALTIFTFGM 598
            :|                 ::|:.                      .:|||: :...|.:.|||.
plant   404 MYGNYVNFFCKTDNEYNDLATIFFNTQDDAIRNLFSAKTMREFSAQSLLTFLAMFYTLAVVTFGT 468

  Fly   599 KVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGV 663
            .||||.|:|.:::|:..||:||:.|.:| |...|             |..|.||::|||:.|||.
plant   469 AVPAGQFVPGIMIGSTYGRLVGMFVVRF-YKKLN-------------IEEGTYALLGAASFLGGS 519

  Fly   664 TRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEF-AH 727
            .||||||.|||.|:|..::.:..:|...:.||.||||. .:|:|:....|.|.|.|:|:.:: ..
plant   520 MRMTVSLCVIMVEITNNLKLLPLIMLVLLISKAVGDAF-NEGLYEVQARLKGIPLLESRPKYHMR 583

  Fly   728 TTLAADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVV-VSRENQYLV-GFVLRRDLNL 790
            ..:|.:..|.::..:|..:    :.|.||.::|...:|||:||: .:|..:.|| |.|||..|.:
plant   584 QMIAKEACQSQKVISLPRV----IRVADVASILGSNKHNGFPVIDHTRSGETLVIGLVLRSHLLV 644

  Fly   791 AI--------------GNAKRLIEGISSSSIVLFTSSQPIQNLGPQPLKLKKILDMAPI------ 835
            .:              .:|:.:....|..:..:.:....|:::......|:..:|:||.
plant   645 LLQSKVDFQHSPLPCDPSARNIRHSFSEFAKPVSSKGLCIEDIHLTSDDLEMYIDLAPFLNPSPY 709

  Fly   836 TVTDQTPMETVVDMFRKLGLRQT-LVTHNGRLLGVITKKDVL 876
            .|.:...:..|.::||:||||.. :|....|::|:||:||:|
plant   710 VVPEDMSLTKVYNLFRQLGLRHLFVVPRPSRVIGLITRKDLL 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	167/566 (30%)
		Voltage_CLC	298..699	CDD:279048	146/463 (32%)
		CBS	738..876	CDD:223591	40/160 (25%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	41/159 (26%)
CLC-D	NP_197996.1	ClC_6_like	45..574	CDD:239657	177/623 (28%)
		Voltage_CLC	130..537	CDD:279048	142/445 (32%)
		CBS_pair_EriC_assoc_euk_bac	593..751	CDD:239964	40/161 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.770