Protein Alignment ClC-c and CLC-D

DIOPT Version :10

• Sequence 1: NP_730105.3
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_197996.1
• Gene: CLC-D / 832693
• AraportID: AT5G26240
• Length: 792
• Species: Arabidopsis thaliana
• Alignment Length: 822
• Identity: 226/822 - (27%)
• Similarity: 373/822 - (45%)
• Gaps: 200/822 - (24%)

  Fly   156 DDIPGIGQYED----FHTIDWQ--RDIA-RDRMRHR-------YIVKKRQDSLWDLIKGSIDAGS 206
            |||..:..:.|    .:::|::  .:.| |:...||       |:..|
plant    29 DDITLLNSHRDGDGGVNSLDYEVIENYAYREEQAHRGKLYVGYYVAVK----------------- 76

  Fly   207 GWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTW 271
             |...||:||..|..|..:::...                                 |.:.|| :
plant    77 -WFFSLLIGIGTGLAAVFINLSVE---------------------------------NFAGWK-F 106

  Fly   272 PEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLG 336
            ...|.:.:..   |...:|.|:|..|:....||.::..|||.|.||||||||..|:|..|.|.|.
plant   107 ALTFAIIQKS---YFAGFIVYLLINLVLVFSSAYIITQFAPAAAGSGIPEIKGYLNGIDIPGTLL 168

  Fly   337 KWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFS-------HV---FPKYGRNEAKKREI 391
            ..||:.|..|.:.||..||.||||||:||..:||.::..       |:   :|:..:::..:|::
plant   169 FRTLIGKIFGSIGSVGGGLALGKEGPLVHTGACIASLLGQGGSTKYHLNSRWPQLFKSDRDRRDL 233

  Fly   392 LSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLT---------PF 447
            ::...||||:.||.||:|||||:||||:.::..:.:||.||.:.|.|.|:|:..         .|
plant   234 VTCGCAAGVAAAFRAPVGGVLFALEEVTSWWRSQLMWRVFFTSAIVAVVVRTAMGWCKSGICGHF 298

  Fly   448 GNEHSVLFFV-EYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLW---WCRYRKFSKLGQYPVME 508
            |....:::.| :....:.|.||:|...:|::||::|..|.:..|:   |.|.....|..:..::|
plant   299 GGGGFIIWDVSDGQDDYYFKELLPMAVIGVIGGLLGALFNQLTLYMTSWRRNSLHKKGNRVKIIE 363

  Fly   509 VLFVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPG 573
            ...::.:|:.|.:..|            |:.||||...:.|            :|.||...| ||
plant   364 ACIISCITSAISFGLP------------LLRKCSPCPESVP------------DSGIECPRP-PG 403

  Fly   574 VY-----------------SSIWL----------------------LMLTFI-LKLALTIFTFGM 598
            :|                 ::|:.                      .:|||: :...|.:.|||.
plant   404 MYGNYVNFFCKTDNEYNDLATIFFNTQDDAIRNLFSAKTMREFSAQSLLTFLAMFYTLAVVTFGT 468

  Fly   599 KVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGV 663
            .||||.|:|.:::|:..||:||:.|.:| |...|             |..|.||::|||:.|||.
plant   469 AVPAGQFVPGIMIGSTYGRLVGMFVVRF-YKKLN-------------IEEGTYALLGAASFLGGS 519

  Fly   664 TRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEF-AH 727
            .||||||.|||.|:|..::.:..:|...:.||.||||. .:|:|:....|.|.|.|:|:.:: ..
plant   520 MRMTVSLCVIMVEITNNLKLLPLIMLVLLISKAVGDAF-NEGLYEVQARLKGIPLLESRPKYHMR 583

  Fly   728 TTLAADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVV-VSRENQYLV-GFVLRRDLNL 790
            ..:|.:..|.::..:|..:    :.|.||.::|...:|||:||: .:|..:.|| |.|||..|.:
plant   584 QMIAKEACQSQKVISLPRV----IRVADVASILGSNKHNGFPVIDHTRSGETLVIGLVLRSHLLV 644

  Fly   791 AI--------------GNAKRLIEGISSSSIVLFTSSQPIQNLGPQPLKLKKILDMAPI------ 835
            .:              .:|:.:....|..:..:.:....|:::......|:..:|:||.
plant   645 LLQSKVDFQHSPLPCDPSARNIRHSFSEFAKPVSSKGLCIEDIHLTSDDLEMYIDLAPFLNPSPY 709

  Fly   836 TVTDQTPMETVVDMFRKLGLRQT-LVTHNGRLLGVITKKDVL 876
            .|.:...:..|.::||:||||.. :|....|::|:||:||:|
plant   710 VVPEDMSLTKVYNLFRQLGLRHLFVVPRPSRVIGLITRKDLL 751

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_730105.3	ClC_3_like	215..719	CDD:239656	167/566 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	730..878	CDD:341367	43/170 (25%)
		CBS repeat	736..829	CDD:341367	23/108 (21%)
		CBS repeat	835..877	CDD:341367	16/49 (33%)
CLC-D	NP_197996.1	ClC_6_like	45..574	CDD:239657	177/623 (28%)
		CBS_pair_voltage-gated_CLC_euk_bac	593..751	CDD:341367	40/161 (25%)
		CBS repeat	593..703	CDD:341367	24/113 (21%)
		CBS repeat	709..751	CDD:341367	15/41 (37%)