Protein Alignment ClC-c and clcn1a

DIOPT Version :9

• Sequence 1: NP_001261922.1
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: XP_009292335.1
• Gene: clcn1a / 795133
• ZFINID: ZDB-GENE-060503-333
• Length: 1011
• Species: Danio rerio
• Alignment Length: 995
• Identity: 257/995 - (25%)
• Similarity: 391/995 - (39%)
• Gaps: 309/995 - (31%)

  Fly    43 LDGTFRDHPLAQHTKLTTSLTAAGTDDEDMIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDT 107
            |.|.:|:||                                       |||    .|..||....
Zfish    18 LYGEYREHP---------------------------------------GGS----QRREATRLLM 39

  Fly   108 ERD---FGHSGGNG-------GGNHHNQRTMHQHVPTHSAFGDPMDGALSFYGSSDVQDDIPGIG 162
            ||.   .||...:|       |.:|...|:.| |...|.   |...|::         .|.|
Zfish    40 ERQRKKHGHHHHHGHYHHAHQGRSHSRSRSRH-HSRPHL---DLEIGSI---------HDRP--- 88

  Fly   163 QYEDFHTIDWQRDIARDRMR------HRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCV 221
            :.|..||..:::..:..:.|      .:::|.|              .|..|:.::|:||....|
Zfish    89 EEEQGHTSSFKKRRSYSKCRDCVARVQKFLVSK--------------LGEDWIFLVLLGITMALV 139

  Fly   222 AGMVDIGASWMSDLKHGICPPAF-WFNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPY 285
                    ||..|........|: ||..|.           .||...                .|
Zfish   140 --------SWSMDYASAKSLQAYKWFYGEL-----------RGNIPL----------------QY 169

  Fly   286 IVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLS 350
            :| ::.|.:..:|||||...||   ||.|.||||||:||||.|.:::.||.....:.|.|||...
Zfish   170 LV-WVSYPMVLILFASLFCHLV---APQAIGSGIPEMKTILRGVVLKEYLTLKAFVAKVVGLTAG 230

  Fly   351 VSAGLTLGKEGPMVHIAS-CIG------NIFSHVFPK-YGRNEAKKREILSAAAAAGVSVAFGAP 407
            :.:|:.:|||||.||||| |..      :.||.|:.. ||..     :||:...|.||...||.|
Zfish   231 LGSGMPVGKEGPFVHIASICAAVLSKFMSFFSGVYQSPYGYT-----DILTVGCAVGVGCCFGTP 290

  Fly   408 IGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEH---SVLFFVEYNK--PWIFFE 467
            :||||||:|..|.||.::..||.:|.|..:||:.|.|:.|..:.   :.||...:..  |:...|
Zfish   291 LGGVLFSIEVTSTYFAVRNYWRGYFAATFSAFIFRVLSVFNKDAVTITALFRTNFRMDFPFDLQE 355

  Fly   468 LIPFVFLGIMGGVIGTFFIKAN----LWWCRYRKFSK-LGQYPVMEVLFVTLVTAIICYPNPFTR 527
            |..|..:||..|.:|.||:..|    |:..|....:: |.::.::....||||...:.:|..|.:
Zfish   356 LPAFAIIGISCGFLGAFFVYLNRQVVLFMRRPNILTRFLTKHRLVFPAVVTLVVTTLTFPPGFGQ 420

  Fly   528 MNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIW---------LLML 583
            ....||:        |.:..|.|.|    |.|....:.....||.| .|::|         :|:|
Zfish   421 FMAGELM--------PRECINSLFD----NFTWTKIWGSPLPPGLG-RSAVWFHPDVSIFVILIL 472

  Fly   584 TFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNLITP 648
            ..|:|..::..:..|.:|:|.|:|..:|||..||:||   |..|..:|:...|.|..   ..|.|
Zfish   473 FLIMKFWMSAVSTTMPIPSGAFMPVFVLGAAFGRLVG---EIMATLFPHGILFDGIL---YRIIP 531

  Fly   649 GLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIAL 713
            |.|||:||||:.|.||. |||..||.|||||.:.:|:|:|.|.:.:..|...| :..:||:.|..
Zfish   532 GGYAVIGAAALTGAVTH-TVSTAVICFELTGQISHILPMMVAVILANMVAQGL-QPSLYDSIIQF 594

  Fly   714 NGYPFLDSKEEFAHTTLAADVMQPKRNETLNVITQDSM-----------TVDDVENLLKETEHNG 767
            ...|:| .:..|.|.:            ..|:..:|.|           |..:|.:||..|....
Zfish   595 KKLPYL-PELGFGHIS------------QYNIFVEDIMVRKVKFLCSQSTYREVLHLLDSTSLKT 646

  Fly   768 YPVVVSRENQYLVGFVLRRDLNLAI--------------GNA----------------------- 795
            :|:|.|:::..|:|.:.|.:| ||:              |.:
Zfish   647 FPLVDSKDSMILLGSIERSEL-LALCDWWLSAERRILIQGQSPQGQVPCAKISWESFAFVDEDEE 710

  Fly   796 --------------------------------------------KRLIEGISSSSIVLFTSSQPI 816
                                                        :||:..:.|||....|..||.
Zfish   711 DEEENVDEKTIPVQEERNGPVPPPKPSEPSTNHTSPDKGPSQSFRRLLRNLFSSSSERHTEGQPQ 775

  Fly   817 QNLGP--------------------QPLKLKKI-LDMAPITVTDQTPMETVVDMFRKLGLRQTLV 860
            :...|                    :||::.:| :|.:|..:.::|.:.....:|..|||....|
Zfish   776 EPYPPPLTDTMTPEQIKAWEESEMDKPLEINQIRIDPSPFQLVERTSLHKTHTLFSLLGLSHAYV 840

  Fly   861 THNGRLLGVITKKDVLRHVK 880
            |:.|:|:||:..|::.:.::
Zfish   841 TNTGKLVGVVALKELQKAIE 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	175/531 (33%)
		Voltage_CLC	298..699	CDD:279048	155/427 (36%)
		CBS	738..876	CDD:223591	44/250 (18%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	44/249 (18%)
clcn1a	XP_009292335.1	ClC_1_like	125..602	CDD:239655	178/542 (33%)
		Voltage_CLC	178..581	CDD:279048	155/430 (36%)
		CBS_pair	<612..669	CDD:301603	15/57 (26%)
		CBS_pair_EriC_assoc_euk_bac	<810..858	CDD:239964	14/47 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590038
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740