Protein Alignment ClC-c and Clcnkb

DIOPT Version :10

• Sequence 1: NP_730105.3
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_775126.1
• Gene: Clcnkb / 79430
• RGDID: 628639
• Length: 687
• Species: Rattus norvegicus
• Alignment Length: 652
• Identity: 186/652 - (28%)
• Similarity: 303/652 - (46%)
• Gaps: 103/652 - (15%)

  Fly   281 GTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSV 345
            |.| :::.|:.:.::.:...|.|:...:...|.:.||||||:||||:|.|:..||.......|.|
  Rat    86 GDG-HLLRYLSWTVYPVALLSFSSGFSQSITPSSGGSGIPEVKTILTGVILEDYLDIKNFGAKVV 149

  Fly   346 GLMLSVSAGLT--LGKEGPMVHIASCIGNIFSHVFPK---YGRNEAKKREILSAAAAAGVSVAFG 405
            ||..:::.|.|  |||.||.||::..|......|..|   ...|:.|:.|:|:|.||.||:..|.
  Rat   150 GLSCTLATGSTIFLGKLGPFVHLSVMIAAYLGRVRTKTVGEPENKTKEMELLAAGAAVGVATVFA 214

  Fly   406 APIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSVL-------FFVE--YNK 461
            |||.|||||:|.:|.:|.:...||.||.|...||:...|..|.:|...:       |.|:  ::.
  Rat   215 APISGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFHLLAVFNSEQETITSIYKTSFPVDIPFDL 279

  Fly   462 PWIFFELIPFVFLGIMGGVI----------GTFFIKANLWWCRYRKFSKLGQYPVMEVLFVTLVT 516
            |.|||    ||.||.:.|::          ..||:|:|.:..:....||    |:...| ..:|.
  Rat   280 PEIFF----FVALGAICGILSCGYNYCQRTSLFFLKSNGFTSKLLATSK----PLYSAL-AAVVL 335

  Fly   517 AIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIE-VTEPGPGVYSSIWL 580
            |.|.||....|        .:.|:.|..:....|.|.....:.:.||... ..||.|   .::||
  Rat   336 ASITYPPGVGR--------FMASRLSMSEYLETLFDNNSWALMTKNSSPPWSAEPDP---QNLWL 389

  Fly   581 ------------LMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNI 633
                        |:...::|..:.|....:.:|||.|:|..:.||.:||:.|   |..:.::|.
  Rat   390 EWCHPQMTVFGTLVFFLVMKFWMLILATTIPIPAGYFLPIFVYGAAIGRLFG---EVLSLAFPE- 450

  Fly   634 WFFTGECADSNL--ITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKW 696
                |..|...:  |.||.||:.||||..|.||. |:|..::.||::|.:.:.:|::.|.:|:..
  Rat   451 ----GIVAGGKVSPIMPGAYALAGAAAFSGAVTH-TLSTALLAFEVSGQIVHALPVLMAVLAANA 510

  Fly   697 VGDALGRQGIYDAHIALNGYPFLD---SKEEFAHTTLAADVMQPKRNETLNVITQDSMTVDDVEN 758
            :..:. :...||..|.:...|:|.   .::..:|.......|    |.||..:.:| |.:::|..
  Rat   511 ICQSY-QPSFYDGTIIVKKLPYLPWIRGRKIGSHLVTVGHFM----NCTLTTLAKD-MPLEEVIK 569

  Fly   759 LLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLFTSSQPIQNLGPQP 823
            ::..|:...||:|.:.|:|.|||.|.|          ..|::.:.:.|    .|..|    |.||
  Rat   570 VVISTDVTQYPLVETTESQVLVGIVKR----------THLVQSLHTDS----ASWAP----GQQP 616

  Fly   824 LKLKKIL----DMAPIT--VTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQM 882
            . |:.||    ...|:|  ::.:|.:....::|..|.|:...||..||.:|.::..::.:.:..:
  Rat   617 C-LQDILANGCPTQPVTLQLSTETSLHETHNLFELLNLQLLFVTSRGRAVGSVSWVELKKAISTL 680

  Fly   883 DN 884
            .|
  Rat   681 TN 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_730105.3	ClC_3_like	215..719	CDD:239656	144/476 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	730..878	CDD:341367	39/153 (25%)
		CBS repeat	736..829	CDD:341367	25/92 (27%)
		CBS repeat	835..877	CDD:341367	10/43 (23%)
Clcnkb	NP_775126.1	ClC_1_like	49..533	CDD:239655	144/477 (30%)
		CBS_pair_voltage-gated_CLC_euk_bac	546..676	CDD:341367	39/153 (25%)
		CBS repeat	552..627	CDD:341367	27/94 (29%)
		CBS repeat	633..675	CDD:341367	9/41 (22%)