Protein Alignment ClC-c and Clcnkb

DIOPT Version :9

• Sequence 1: NP_001261922.1
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_775126.1
• Gene: Clcnkb / 79430
• RGDID: 628639
• Length: 687
• Species: Rattus norvegicus
• Alignment Length: 652
• Identity: 186/652 - (28%)
• Similarity: 303/652 - (46%)
• Gaps: 103/652 - (15%)

  Fly   281 GTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSV 345
            |.| :::.|:.:.::.:...|.|:...:...|.:.||||||:||||:|.|:..||.......|.|
  Rat    86 GDG-HLLRYLSWTVYPVALLSFSSGFSQSITPSSGGSGIPEVKTILTGVILEDYLDIKNFGAKVV 149

  Fly   346 GLMLSVSAGLT--LGKEGPMVHIASCIGNIFSHVFPK---YGRNEAKKREILSAAAAAGVSVAFG 405
            ||..:::.|.|  |||.||.||::..|......|..|   ...|:.|:.|:|:|.||.||:..|.
  Rat   150 GLSCTLATGSTIFLGKLGPFVHLSVMIAAYLGRVRTKTVGEPENKTKEMELLAAGAAVGVATVFA 214

  Fly   406 APIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSVL-------FFVE--YNK 461
            |||.|||||:|.:|.:|.:...||.||.|...||:...|..|.:|...:       |.|:  ::.
  Rat   215 APISGVLFSIEVMSSHFSVWDYWRGFFAATCGAFMFHLLAVFNSEQETITSIYKTSFPVDIPFDL 279

  Fly   462 PWIFFELIPFVFLGIMGGVI----------GTFFIKANLWWCRYRKFSKLGQYPVMEVLFVTLVT 516
            |.|||    ||.||.:.|::          ..||:|:|.:..:....||    |:...| ..:|.
  Rat   280 PEIFF----FVALGAICGILSCGYNYCQRTSLFFLKSNGFTSKLLATSK----PLYSAL-AAVVL 335

  Fly   517 AIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIE-VTEPGPGVYSSIWL 580
            |.|.||....|        .:.|:.|..:....|.|.....:.:.||... ..||.|   .::||
  Rat   336 ASITYPPGVGR--------FMASRLSMSEYLETLFDNNSWALMTKNSSPPWSAEPDP---QNLWL 389

  Fly   581 ------------LMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNI 633
                        |:...::|..:.|....:.:|||.|:|..:.||.:||:.|   |..:.::|.
  Rat   390 EWCHPQMTVFGTLVFFLVMKFWMLILATTIPIPAGYFLPIFVYGAAIGRLFG---EVLSLAFPE- 450

  Fly   634 WFFTGECADSNL--ITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKW 696
                |..|...:  |.||.||:.||||..|.||. |:|..::.||::|.:.:.:|::.|.:|:..
  Rat   451 ----GIVAGGKVSPIMPGAYALAGAAAFSGAVTH-TLSTALLAFEVSGQIVHALPVLMAVLAANA 510

  Fly   697 VGDALGRQGIYDAHIALNGYPFLD---SKEEFAHTTLAADVMQPKRNETLNVITQDSMTVDDVEN 758
            :..:. :...||..|.:...|:|.   .::..:|.......|    |.||..:.:| |.:::|..
  Rat   511 ICQSY-QPSFYDGTIIVKKLPYLPWIRGRKIGSHLVTVGHFM----NCTLTTLAKD-MPLEEVIK 569

  Fly   759 LLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLFTSSQPIQNLGPQP 823
            ::..|:...||:|.:.|:|.|||.|.|          ..|::.:.:.|    .|..|    |.||
  Rat   570 VVISTDVTQYPLVETTESQVLVGIVKR----------THLVQSLHTDS----ASWAP----GQQP 616

  Fly   824 LKLKKIL----DMAPIT--VTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQM 882
            . |:.||    ...|:|  ::.:|.:....::|..|.|:...||..||.:|.::..::.:.:..:
  Rat   617 C-LQDILANGCPTQPVTLQLSTETSLHETHNLFELLNLQLLFVTSRGRAVGSVSWVELKKAISTL 680

  Fly   883 DN 884
            .|
  Rat   681 TN 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	144/476 (30%)
		Voltage_CLC	298..699	CDD:279048	137/439 (31%)
		CBS	738..876	CDD:223591	38/143 (27%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	37/142 (26%)
Clcnkb	NP_775126.1	ClC_1_like	49..533	CDD:239655	144/477 (30%)
		Voltage_CLC	106..513	CDD:279048	136/435 (31%)
		CBS	547..604	CDD:278968	19/71 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D271925at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.760