DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-c and Clcnka

DIOPT Version :9

Sequence 1:NP_001261922.1 Gene:ClC-c / 39759 FlyBaseID:FBgn0036566 Length:893 Species:Drosophila melanogaster
Sequence 2:NP_445779.2 Gene:Clcnka / 79425 RGDID:68435 Length:687 Species:Rattus norvegicus


Alignment Length:664 Identity:195/664 - (29%)
Similarity:303/664 - (45%) Gaps:127/664 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   281 GTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSV 345
            |.| :::.|:.:.::.:...|.|:...:..:|::.|||:||:||:|||.::..||.......|.|
  Rat    86 GDG-HLLRYLSWTVYPVALLSFSSGFSQSISPFSGGSGLPELKTMLSGVVLEDYLDIKNFGAKVV 149

  Fly   346 GLMLSVSAGLT--LGKEGPMVHIASCIGNIFSHVFPK---YGRNEAKKREILSAAAAAGVSVAFG 405
            ||..:::.|.|  |||.||.||::..|......|..|   ...|:||:.|:||||||.||:..|.
  Rat   150 GLSCTLATGSTIFLGKVGPFVHLSVMISAYLGRVRAKTIGETENKAKEIEMLSAAAAVGVATVFA 214

  Fly   406 APIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSVL-------FFVE--YNK 461
            ||..|||||:|.:|.:|.:...||.||.|...||:.|.|..|.:|...:       |.|:  ::.
  Rat   215 APFSGVLFSIEVMSSHFSVWNYWRGFFAATCGAFMFRLLGVFNSEQETITSIYKTRFRVDVPFDL 279

  Fly   462 PWIFFELIPFVFLGIMGGVIG--------TF--FIKANLWWCRYRKFSKLGQYPVMEVLFVTLVT 516
            |.|||    ||.||.:.||:.        ||  |||.|.:..|....||    |....| |.||.
  Rat   280 PEIFF----FVALGFICGVLSCAYLFCQRTFLCFIKTNRYTSRLLATSK----PSYAAL-VALVL 335

  Fly   517 AIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIE-VTEPGPGVYSSIWL 580
            |.|.||....|        .:.|:.|..:..:.|.|.....:.:.||... ..||.|   .::||
  Rat   336 ASITYPPGVGR--------FMASRLSMAEHLHSLFDNNSWALMTRNSSPPWPAEPDP---QNLWL 389

  Fly   581 ------------LMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNI 633
                        |....::|..:.|....:.:|||.|:|..::||.:||::|   |..:.::|. 
  Rat   390 EWCHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFIIGAAIGRLLG---EALSVAFPE- 450

  Fly   634 WFFTGECA--DSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKW 696
                |..|  :.|.|.||.||:.||||..|.||. |:|..::.|||||.:.:.:|::.|.:|:..
  Rat   451 ----GIVAGREVNPIMPGGYALAGAAAFSGAVTH-TISTALLAFELTGQIVHALPVLMAVLAANA 510

  Fly   697 VGDALGRQGIYDAHIALNGYPFLD------------SKEEFAH---TTLAADVMQPKRNETLNVI 746
            :.... :...||..|.....|:|.            :.|.|.:   ||||.|.            
  Rat   511 ISQNC-QPSFYDGTIMAKKLPYLP
WIRGRQIGSYPVTVEHFMNCNLTTLAKDT------------ 562

  Fly   747 TQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLFT 811
                 .:::|..::..||.:.||:|.:||:|.|||.|.|..|..|:                   
  Rat   563 -----PLEEVVKVVTSTEVSQYPLVETRESQTLVGIVERTHLVQAL------------------- 603

  Fly   812 SSQPIQNLGPQPLKLKKIL----DMAPIT--VTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVI 870
            .:||......|...|:.||    ...|:|  ::.:|.:.....:|.:|.|:...||..|:.:|.:
  Rat   604 QTQPASWAPGQERFLQDILAGGCPTQPVTLQLSPETSLYQAHSLFERLTLQSLFVTSRGKAVGSV 668

  Fly   871 TKKDVLRHVKQMDN 884
            :..::.:.:..:.|
  Rat   669 SWAELKKAISTLIN 682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-cNP_001261922.1 ClC_3_like 215..719 CDD:239656 154/476 (32%)
Voltage_CLC 298..699 CDD:279048 147/439 (33%)
CBS 738..876 CDD:223591 32/143 (22%)
CBS_pair_EriC_assoc_euk_bac 741..878 CDD:239964 32/142 (23%)
ClcnkaNP_445779.2 ClC_1_like 49..533 CDD:239655 154/477 (32%)
CBS_pair_voltage-gated_CLC_euk_bac 546..676 CDD:341367 39/165 (24%)
CBS repeat 552..627 CDD:341367 27/110 (25%)
CBS repeat 633..675 CDD:341367 8/41 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166348874
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55339
OrthoDB 1 1.010 - - D271925at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.860

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