DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and clcn4

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001070786.1	Gene:	clcn4 / 768175	ZFINID:	ZDB-GENE-061013-353	Length:	768	Species:	Danio rerio

Alignment Length:	767	Identity:	450/767 - (58%)
Similarity:	582/767 - (75%)	Gaps:	25/767 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 DPMDGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDA 204
            :.|:||.:.....|  :..|.:|.|||||||||.|:.::|..|||.|..|.::|:|:.||..:||
Zfish    14 EEMNGAGNLMDFLD--EPFPDVGTYEDFHTIDWLREKSKDTDRHRKITSKSKESIWEFIKSLLDA 76

  Fly   205 GSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVF-EEGNCSTW 268
            .||||.:||:|:.:|.:||::|:...||:|||.|:|..|||::.||||:.:.::.| :...|..|
Zfish    77 WSGWLVMLLIGLLSGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFADRDKCPQW 141

  Fly   269 KTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRG 333
            :.|.|:......|.|.|::.|..||||||.|:.|:.||||:||||||||||||||||||||||||
Zfish   142 QKWAELVTGYTEGAGVYVLNYFLYVLWALFFSFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRG 206

  Fly   334 YLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYGRNEAKKREILSAAAAA 398
            ||||||||||:|.|:|:||:||:||||||:||:|.|.||:|..:|.||.:||.|:||:|||||||
Zfish   207 YLGKWTLLIKTVTLVLAVSSGLSLGKEGPLVHVACCCGNLFCSLFSKYSKNEGKRREVLSAAAAA 271

  Fly   399 GVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSVLFFVEYNKPW 463
            ||||||||||||||||||||||||||||||||||.||:|||.|||:.||||...|||:|||:.||
Zfish   272 GVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNNRLVLFYVEYHTPW 336

  Fly   464 IFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVLFVTLVTAIICYPNPFTRM 528
            ...||:||:.||:.||:.||.||:.|:.|||.||.::||:|||:|||.||.:||::.:|||:||.
Zfish   337 YMAELVPFILLGVFGGLWGTLFIRCNIAWCRRRKTTRLGKYPVLEVLAVTGITAVLAFPNPYTRR 401

  Fly   529 NMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEP---------GPGVYSSIWLLMLT 584
            :.:|||..|.:.|...: ::.||||    |.|.|    :|.|         ||||||::|.|.|.
Zfish   402 STSELISELFNDCGALE-SSQLCDY----INSPN----MTRPVDDIPDRPAGPGVYSALWQLTLA 457

  Fly   585 FILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGEC-ADSNLITP 648
            ...|:.:||||||||:|:||||||:.:|||.||||||.|||.||.:.:...|...| ..::.:||
Zfish   458 LAFKIIITIFTFGMKIPSGLFIPSMAVGAIAGRIVGIAVEQMAYHHHDWIIFKNWCRPGADCVTP 522

  Fly   649 GLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIAL 713
            ||||:|||||.|||||||||||||||||||||:.|||||||||:.||||.||.|::|||:|||.|
Zfish   523 GLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIQL 587

  Fly   714 NGYPFLDSKEEFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQ 777
            ||||:|| ::||.|.|||.|||:|:|:| .|:|:||||.|:::.|.|:..|::||:|||||||::
Zfish   588 NGYPYLD-QDEFTHRTLATDVMRPRRSEPPLSVLTQDSSTLEEAEALITHTDYNGFPVVVSRESE 651

  Fly   778 YLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLFTSSQP-IQNLGPQPLKLKKILDMAPITVTDQT 841
            .|:|||.||||.|||.||::..:|:.|:|:|.||...| :.....|||||::||:::|.||||.|
Zfish   652 RLIGFVQRRDLILAIKNARQKQDGVVSNSVVYFTEDAPQLPASNTQPLKLRRILNLSPFTVTDHT 716

  Fly   842 PMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQMDNEDPNTVLFN 893
            |||||||:||||||||.|||.:|||||:|||||||||:..|.|:||.:::||
Zfish   717 PMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAHMMNQDPESIMFN 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	312/514 (61%)
		Voltage_CLC	298..699	CDD:279048	264/410 (64%)
		CBS	738..876	CDD:223591	82/139 (59%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	83/138 (60%)
clcn4	NP_001070786.1	ClC_3_like	87..593	CDD:239656	312/514 (61%)
		Voltage_CLC	171..573	CDD:279048	264/410 (64%)
		CBS	606..751	CDD:223591	86/144 (60%)
		CBS_pair_EriC_assoc_euk_bac	615..753	CDD:239964	82/137 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590035
Domainoid	1	1.000	539	1.000	Domainoid score	I261
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	923	1.000	Inparanoid score	I348
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D116173at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		otm24575
orthoMCL	1	0.900	-	-		OOG6_100336
Panther	1	1.100	-	-	O	PTHR45711
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1878
SonicParanoid	1	1.000	-	-		X829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800