Protein Alignment ClC-c and clcn5

DIOPT Version :9

• Sequence 1: NP_001261922.1
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_001039210.1
• Gene: clcn5 / 734069
• XenbaseID: XB-GENE-5957241
• Length: 808
• Species: Xenopus tropicalis
• Alignment Length: 858
• Identity: 480/858 - (55%)
• Similarity: 616/858 - (71%)
• Gaps: 82/858 - (9%)

  Fly    60 TSLTA--AGTDDEDMIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNH 122
            :|||:  :.|.||||::|                             ::...||
 Frog     9 SSLTSFHSSTSDEDMVEI-----------------------------NEATLDF----------- 33

  Fly   123 HNQRTMHQHVPTHSAFGDPMD-----GALSF-----YGSSDVQD--DIPGIGQYEDFHTIDWQRD 175
                ||...||       |:|     |.:|:     :|.|.|.|  |:||:|.||||:||||.|:
 Frog    34 ----TMTDDVP-------PIDRDMAGGFVSYNGNGLHGPSKVMDFLDVPGVGTYEDFNTIDWVRE 87

  Fly   176 IARDRMRHRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGIC 240
            .:|||.|||.|:.|.::|.|.|::...||.|||:.:||:|:.||.:||::||.:.||:|||.|||
 Frog    88 KSRDRDRHREILSKSKESTWALLRSISDAFSGWMLMLLIGLTAGSLAGLIDISSHWMTDLKEGIC 152

  Fly   241 PPAFWFNREQCCYPAKQSVFEE-GNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSA 304
            .|.||||.||||:.:....||: .||..|::|.::......|..|||:.|..||||||||:.|:.
 Frog   153 LPWFWFNHEQCCWQSNNVTFEDRNNCPEWRSWSQLVLGRSEGAFPYILNYFMYVLWALLFSLLAV 217

  Fly   305 SLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASC 369
            .|||.|||||||||||||||||||||||||||||||:||::.|:|:||:||:||||||::|:|.|
 Frog   218 LLVRNFAPYACGSGIPEIKTILSGFIIRGYLGKWTLIIKTMTLVLAVSSGLSLGKEGPLIHVACC 282

  Fly   370 IGNIFSHVFPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCA 434
            .|||..|:|.||.:||||:||:|||||||||||||||||||||||||||||||||||||||||.|
 Frog   283 CGNILCHLFTKYRKNEAKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAA 347

  Fly   435 LIAAFVLRSLTPFGNEHSVLFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFS 499
            |:|||.|||:.||||...|||:||::.||...|||||:.|||.||:.|.|||:.|:.||:.||.:
 Frog   348 LVAAFTLRSINPFGNSRLVLFYVEFHAPWHLLELIPFILLGIFGGLWGAFFIRGNIAWCQRRKTT 412

  Fly   500 KLGQYPVMEVLFVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDY-KRMNITSGNS 563
            |||:|||.|||.||.:||::.:||.:|||:.:|:|..|.:.|...| ::.|||| ...|.|.|.:
 Frog   413 KLGRYPVAEVLVVTAITAVLAFPNDYTRMSSSEMISELFNDCGLLD-SSKLCDYVNDYNNTKGGN 476

  Fly   564 FIEVTEPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAY 628
            ..: ...|.|||:::|.|.|..|.|..:||||||||||:||||||:.:||||||::|:.:||.::
 Frog   477 LPD-RAAGNGVYTAMWQLSLALIFKAVITIFTFGMKVPSGLFIPSMAVGAIMGRLLGVAMEQLSF 540

  Fly   629 SYPNIWFFTGEC-ADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAM 692
            .:.:...|.|.| ..::.|||||||:|||||.|||.|||||||||||||||||:.||||||||||
 Frog   541 YHHDWLIFRGWCNQGADCITPGLYAMVGAAACLGGATRMTVSLVVIMFELTGGLEYIVPLMAAAM 605

  Fly   693 ASKWVGDALGRQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDV 756
            .||||.|||||:.||||||.|||||||::||||:|.|||.|||:|:||: .|.|||||||||:|:
 Frog   606 TSKWVADALGRESIYDAHIHLNGYPFLEAKEEFSHKTLAMDVMRPRRNDPILTVITQDSMTVEDI 670

  Fly   757 ENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLFTSSQPIQNLGP 821
            |.::.||.::|:|:|:|||:|.||||||||||.:::.:|::..|||.|:|.:.||...|     |
 Frog   671 EAIINETTYSGFPIVISRESQRLVGFVLRRDLIISVESARKKQEGIVSTSQIYFTEHTP-----P 730

  Fly   822 QP------LKLKKILDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVK 880
            ||      |||:.|:|::|.|:|||||||.|||:||||||||.||||||||||:|||||||:|:.
 Frog   731 QPPTAPPSLKLRAIMDLSPFTITDQTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIA 795

  Fly   881 QMDNEDPNTVLFN 893
            ||.|:||:::|||
 Frog   796 QMANQDPDSILFN 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	316/506 (62%)
		Voltage_CLC	298..699	CDD:279048	259/402 (64%)
		CBS	738..876	CDD:223591	85/144 (59%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	85/143 (59%)
clcn5	NP_001039210.1	ClC_3_like	127..632	CDD:239656	316/506 (62%)
		CBS_pair_voltage-gated_CLC_euk_bac	643..793	CDD:341367	93/154 (60%)
		CBS repeat	649..744	CDD:341367	49/99 (49%)
		CBS repeat	750..792	CDD:341367	35/41 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	544	1.000	Domainoid score	I261
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	942	1.000	Inparanoid score	I340
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D116173at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		otm48457
Panther	1	1.100	-	-	LDO	PTHR45711
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080