DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and Clcn4

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_006256890.1	Gene:	Clcn4 / 60586	RGDID:	708381	Length:	774	Species:	Rattus norvegicus

Alignment Length:	757	Identity:	461/757 - (60%)
Similarity:	584/757 - (77%)	Gaps:	8/757 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 GALSFYGS-SDVQDD-IPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGS 206
            ||:|..|: .|..|: .|.:|.|||||||||.|:.:||..|||.|..|.::|:|:.||..:||.|
  Rat    19 GAMSASGNLMDFLDEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIKSLLDAWS 83

  Fly   207 GWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEE-GNCSTWKT 270
            ||:.:||:|:.||.:||::|:...||:|||.|:|..|||::.||||:.:.::.||: ..|..|:.
  Rat    84 GWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQK 148

  Fly   271 WPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYL 335
            |.|:......|...||:.|:.|:|||||||.|:.||||:||||||||||||||||||||||||||
  Rat   149 WSELLLSQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYL 213

  Fly   336 GKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYGRNEAKKREILSAAAAAGV 400
            ||||||||:|.|:|.||:||:||||||:||:|.|.||.||.:|.||.:||.|:||:|||||||||
  Rat   214 GKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGV 278

  Fly   401 SVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSVLFFVEYNKPWIF 465
            ||||||||||||||||||||||||||||||||.||:|||.|||:.||||...|||:|||:.||..
  Rat   279 SVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYM 343

  Fly   466 FELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVLFVTLVTAIICYPNPFTRMNM 530
            .||.||:.||:.||:.||.|.:.|:.|||.||.::||:|||:||:.||.:||||.||||:||.:.
  Rat   344 AELFPFILLGVFGGLWGTVFTRCNIAWCRRRKTTRLGKYPVLEVIVVTAITAIIAYPNPYTRQST 408

  Fly   531 NELIFLLVSKCSPGDVTNPLCDY-KRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFILKLALTIF 594
            :|||..|.:.|...: ::.|||| ...|:|.....|.....|.|||:::|.|.|..|.|:.:|||
  Rat   409 SELISELFNDCGALE-SSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVITIF 472

  Fly   595 TFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGEC-ADSNLITPGLYAVVGAAA 658
            |||||:|:||||||:.:||:.||:|||||||.||.:.:...|...| ..::.:||||||:|||||
  Rat   473 TFGMKIPSGLFIPSMAVGAMAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAA 537

  Fly   659 VLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKE 723
            .|||||||||||||||||||||:.|||||||||:.||||.||.|::|||:|||.||||||||.|:
  Rat   538 CLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKD 602

  Fly   724 EFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRD 787
            ||.|.|||.|||:|:|.| .|:|:|||||||:|||.|:|||::||:||||||:::.|:||..||:
  Rat   603 EFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRE 667

  Fly   788 LNLAIGNAKRLIEGISSSSIVLFTSSQP-IQNLGPQPLKLKKILDMAPITVTDQTPMETVVDMFR 851
            |.|||.||::..|||.|:||:.||...| :....|.||||::||:::|.||||.||||||||:||
  Rat   668 LILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFR 732

  Fly   852 KLGLRQTLVTHNGRLLGVITKKDVLRHVKQMDNEDPNTVLFN 893
            ||||||.|||.:|||||:|||||||||:.||.|:||.:::||
  Rat   733 KLGLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	313/506 (62%)
		Voltage_CLC	298..699	CDD:279048	264/402 (66%)
		CBS	738..876	CDD:223591	87/139 (63%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	88/138 (64%)
Clcn4	XP_006256890.1	ClC_3_like	92..598	CDD:239656	313/506 (62%)
		Voltage_CLC	176..578	CDD:279048	264/402 (66%)
		CBS	612..757	CDD:223591	91/144 (63%)
		CBS_pair_EriC_assoc_euk_bac	621..759	CDD:239964	87/137 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348879
Domainoid	1	1.000	546	1.000	Domainoid score	I251
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	964	1.000	Inparanoid score	I310
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D116173at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		otm45379
orthoMCL	1	0.900	-	-		OOG6_100336
Panther	1	1.100	-	-	O	PTHR45711
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.770