DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and clcn1b

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_021322563.1	Gene:	clcn1b / 567478	ZFINID:	ZDB-GENE-100921-11	Length:	956	Species:	Danio rerio

Alignment Length:	924	Identity:	244/924 - (26%)
Similarity:	378/924 - (40%)	Gaps:	251/924 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 RETATESDTERDFGHSGGNGGGNHHNQRTMHQHVPTHSAFGD--PMDGALSFYGSSDVQDDIPGI 161
            |..||...||:.:.....|      ::.|...|...|.|..|  |:...||           |..
Zfish    31 RREATRLLTEKQWKRHADN------SKATRRGHGRAHHASLDVGPLTPGLS-----------PSS 78

  Fly   162 GQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVD 226
            ...:.......|..:||.:   ||||.|              .|..|:.::|:|:....|
Zfish    79 SLIKSHPYFKCQDCLARVQ---RYIVTK--------------LGEDWIFLVLLGLTMALV----- 121

  Fly   227 IGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYIW 291
               ||..|                  |.:.:|:         :.:..::|..:.......:|::.
Zfish   122 ---SWSMD------------------YASAKSI---------QAYKWMYGELKGNVALQYLAWVS 156

  Fly   292 YVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLT 356
            |.:..::||||...||   ||.|.||||||:||||.|.:::.||.....:.|.:||...:.:|:.
Zfish   157 YPIILVVFASLFCHLV---APQAIGSGIPELKTILRGVVLKEYLTLKAFVAKVIGLTAGLGSGMP 218

  Fly   357 LGKEGPMVHIASCIGNIFSHV---FPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEV 418
            :|||||.|||||....:.|.|   |.....|.....:||:...|.||...||.|:||||||:|..
Zfish   219 IGKEGPFVHIASICAAVLSRVMSIFTGVYENPYGYTDILTVGCAVGVGCCFGTPLGGVLFSIEVT 283

  Fly   419 SYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSV----LFFVEYNK--PWIFFELIPFVFLGIM 477
            |.||.::..||.:|.|..:||:.|.|:.: |:.||    ||...:..  |:...||..|..:||.
Zfish   284 STYFAVRNYWRGYFAATFSAFIFRVLSVW-NKDSVTITALFRTNFRMDFPFDLQELPAFAIIGIS 347

  Fly   478 GGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVLF-----------VTLVTAIICYPNPFTRMNMN 531
            .|.:|.||:..|      |:...:.:.|.....|           |||:.|...:|..|.:....
Zfish   348 CGFLGAFFVYLN------RQVVLIMRRPTALTRFLTKHRLIYPGAVTLIIASFTFPPGFGQFMAG 406

  Fly   532 ELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWL---------LMLTFIL 587
            ||:        |.:..|.|.|    |.|....:.....||.| .|:.||         |:|.|::
Zfish   407 ELM--------PRECINSLFD----NYTWTKIWGSPVPPGLG-RSAAWLHPQVSVFVILLLFFVM 458

  Fly   588 KLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNLITPGLYA 652
            |..::..:..|.||:|.|:|..:|||..||:||   |..|..:||...|.|....   |.||.||
Zfish   459 KFWMSAVSTTMPVPSGAFMPVFILGAAFGRLVG---EIMATLFPNGILFDGIVYQ---ILPGGYA 517

  Fly   653 VVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYP 717
            |:||||:.|.||. |||..||.|||||.:.:|:|:|.|.:.:..|...| :..:||:.|.:...|
Zfish   518 VIGAAAMTGAVTH-TVSTAVICFELTGQISHILPMMVAVILANMVAQGL-QPSLYDSIIQVKKLP 580

  Fly   718 FLD-------SKEEFAHTTLAADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRE 775
            :|.       ||    :.....|:|..|    :..::..| |..::::||:.|.....|::.|::
Zfish   581 YLPELGIGHISK----YNIFVEDIMVKK----IKFLSPQS-TYRELKDLLESTSLKTIPLIDSKD 636

  Fly   776 NQYLVGFVLRRDLNLAIG---NAKRLI----EGISS-------SSIV------------------ 808
            ...|:|.:.|.:|..|:.   :|:|.:    ||::|       .|.|
Zfish   637 TMILLGSIERCELQAALDWWLSAERRVYNRGEGMASLVSEGSWESFVFVDEEVGEENRDKGNRVS 701

  Fly   809 ----------------------------------LFTSSQP------------------------ 815
                                              ||:||..
Zfish   702 EECNGPVGSSKTTDISTNHTTSGALKSMRRTFQRLFSSSSSSGQTKPEFTKLSPAGGVKSPAAPP 766

  Fly   816 -IQNLGPQ------------PLKLKKI-LDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRL 866
             :.|:.|:            |:.:.:| :|.:|..:.::|.:.....:|..|||....||..|:|
Zfish   767 VVDNMTPEEIKAWEEKELDKPIGIDQIRVDPSPFQLVERTSLHKTHTLFSLLGLSHAYVTSIGKL 831

  Fly   867 LGVITKKDVLRHVK 880
            :||:..|::.:.::
Zfish   832 VGVVALKELQKAIE 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	171/532 (32%)
		Voltage_CLC	298..699	CDD:279048	156/429 (36%)
		CBS	738..876	CDD:223591	42/241 (17%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	41/240 (17%)
clcn1b	XP_021322563.1	ClC_1_like	107..584	CDD:239655	174/542 (32%)
clcn1b	XP_021322563.1	CBS_pair_EriC_assoc_euk_bac	<795..843	CDD:239964	14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590037
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840