DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ClC-c and clcn3

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_001923503.1	Gene:	clcn3 / 559340	ZFINID:	ZDB-GENE-030131-1699	Length:	874	Species:	Danio rerio

Alignment Length:	881	Identity:	476/881 - (54%)
Similarity:	606/881 - (68%)	Gaps:	96/881 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 NSYITAYQTVMKKSNGHTNGAGGDGDLD--GTFRDHPLAQHTKLTTSLTAAGTDDEDMI--DITP 77
            |||           |..|:.:..:..||  |...|.    ||          |:|::::  |.:|
Zfish    14 NSY-----------NSITSASSDEELLDGAGVIMDF----HT----------TEDDNLLDGDASP 53

  Fly    78 RSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNHHNQRTMHQHVPTHSAFGDPM 142
            .|:.....|||||||:||..|.....|
Zfish    54 GSNYAMSNGGGGGGGASSSTHLLDLLE-------------------------------------- 80

  Fly   143 DGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGSG 207
                         :.|||:|.|:|||||||.|:..:||.|||.|..|:::|.|:..|...||.||
Zfish    81 -------------EPIPGVGTYDDFHTIDWVREKCKDRERHRKINSKKKESAWEFTKSLYDAWSG 132

  Fly   208 WLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVF-EEGNCSTWKTW 271
            ||.|.|.|:|:|.:||.:||.|.||:|||.|:|..|.|||.||||:.:.::.| |...|..||||
Zfish   133 WLVVTLTGLASGALAGGIDIAADWMNDLKEGVCLSAMWFNHEQCCWGSNKTTFAERDKCPQWKTW 197

  Fly   272 PEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLG 336
            .|:......|.|.||:.|..:..|||.||.|:.|||::|||||||||||||||||||||||||||
Zfish   198 AELILGQEQGPGSYIMNYFMFTFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLG 262

  Fly   337 KWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYGRNEAKKREILSAAAAAGVS 401
            ||||:||::.|:|:|::||:||||||:||:|.|.|||||::||||.:|||||||:||||:|||||
Zfish   263 KWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSKNEAKKREVLSAASAAGVS 327

  Fly   402 VAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSVLFFVEYNKPWIFF 466
            |||||||||||||||||||||||||||||||.||:|||||||:.||||...|||:|||:.||..|
Zfish   328 VAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLF 392

  Fly   467 ELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVLFVTLVTAIICYPNPFTRMNMN 531
            ||.||:.||:.||:.|.|||:||:.|||.||.::.|:|||:||:.|..:|||:.:|||:||.|.:
Zfish   393 ELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTRFGKYPVLEVITVAAITAIVAFPNPYTRQNTS 457

  Fly   532 ELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPG------PGVYSSIWLLMLTFILKLA 590
            |||..|.:.|.|.: ::.||.|:.:   ...|..:.|.|.      |||||::|.|.|..:.|:.
Zfish   458 ELIKELFTDCGPLE-SSQLCQYRSL---MNGSQADPTGPDTASAATPGVYSAMWQLSLALVFKII 518

  Fly   591 LTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECAD--SNLITPGLYAV 653
            :||||||:|||:||||||:.:|||.||||||.|||.|| |.:.||...|..:  ::.|||||||:
Zfish   519 MTIFTFGLKVPSGLFIPSMAIGAIAGRIVGIAVEQLAY-YHHDWFVFREWCEVGADCITPGLYAM 582

  Fly   654 VGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPF 718
            |||||.||||||||||||||:||||||:.||||||||.|.|||||||.||:|||:|||.||||||
Zfish   583 VGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPF 647

  Fly   719 LDSKEEFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGF 782
            ||:||||.|||||.:||:|:|:: .|.|:|||.||:.:::.::.||.:||:||:||:|:|.||||
Zfish   648 LDAKEEFTHTTLAREVMRPRRSDPPLAVLTQDDMTLAELQGIISETSYNGFPVIVSKESQRLVGF 712

  Fly   783 VLRRDLNLAIGNAKRLIEGISSSSIVLFTSSQP-IQNLGPQPLKLKKILDMAPITVTDQTPMETV 846
            .||||:.:||.||:|..|||..:|.|.||...| :....|:||||:.||||:|.||||.||||.|
Zfish   713 ALRRDITIAIENARRKQEGIVLNSRVYFTQHAPTLPADSPRPLKLRSILDMSPFTVTDHTPMEIV 777

  Fly   847 VDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQM 882
            ||:||||||||.||||||.:||:||||::|.|::::
Zfish   778 VDIFRKLGLRQCLVTHNGIVLGIITKKNILEHLEEI 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	321/512 (63%)
		Voltage_CLC	298..699	CDD:279048	266/408 (65%)
		CBS	738..876	CDD:223591	80/139 (58%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	80/138 (58%)
clcn3	XP_001923503.1	ClC_3_like	140..648	CDD:239656	321/512 (63%)
clcn3	XP_001923503.1	CBS_pair_EriC_assoc_euk_bac	671..809	CDD:239964	80/137 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590034
Domainoid	1	1.000	539	1.000	Domainoid score	I261
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20435
Inparanoid	1	1.050	923	1.000	Inparanoid score	I348
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D116173at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		otm24575
orthoMCL	1	0.900	-	-		OOG6_100336
Panther	1	1.100	-	-	O	PTHR45711
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1878
SonicParanoid	1	1.000	-	-		X829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940