DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and ClC-b

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_610798.1	Gene:	ClC-b / 36381	FlyBaseID:	FBgn0033755	Length:	813	Species:	Drosophila melanogaster

Alignment Length:	936	Identity:	255/936 - (27%)
Similarity:	415/936 - (44%)	Gaps:	207/936 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EAAAEGNSYITAYQTVMKKSNGHTNGAGGDGDLDGTFRDHPLAQHTKLTTSLTAAGT----DDED 71
            |::||.:..|      ::|..|.|:.|..|..|..  |:.|  ..:.|....|.:|.    ||..
  Fly    13 ESSAEDDPII------LQKEAGPTSKAVQDFGLHQ--REEP--STSALARRATLSGNNHLLDDSQ 67

  Fly    72 MIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNHHNQRTMHQHVPTHS 136
            .:.:...|.|.|:...|..|..:...       :.:|..|          |...||.....|.
  Fly    68 PLLMGNNSVPPDIPINGSAGSPNRNI-------NSSEPIF----------HLRSRTAAASTPN-- 113

  Fly   137 AFGDPMDGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGS 201
                        |.|.|          ||......:| |..|.|:..|:.::|      |:|:
  Fly   114 ------------YESLD----------YEVCENTLFQ-DEQRKRLTERFSLRK------DIIR-- 147

  Fly   202 IDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCS 266
                  |:..:.:||....:|..:||....:|..|:     .|.:|      ..|::|
  Fly   148 ------WIIFIQIGIITALIACTIDIIIEELSIRKY-----TFLYN------SVKENV------- 188

  Fly   267 TWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFII 331
                 |.....||:    .::.|::::|::::..:..|::|....|...|||||::|:.|:|..|
  Fly   189 -----PLSDASDRD----LLIPYLYWLLFSIVPVAFGAAMVTYIEPITAGSGIPQVKSYLNGVKI 244

  Fly   332 RGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFS-----------HVFPKYGRNE 385
            ...:...||.:|::|::.||..||..||||||:|..:.:....|           .:|..: |::
  Fly   245 PRIVRIKTLAVKAIGVITSVVGGLAGGKEGPMIHAGAVVAAGISQGKSTTFLKDFRIFKAF-RDD 308

  Fly   386 AKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLR-SLTPFGN 449
            .:||:.:....|||||.||||||||:||||||.:.::....:||:...::|:.|.|. .|:.:..
  Fly   309 HEKRDFVLGGGAAGVSAAFGAPIGGMLFSLEEAASFWNQNLIWRTLVASIISVFTLNIVLSAYHG 373

  Fly   450 EHSVLF-----FVEYNKP--WIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFS---KLGQY 504
            .:...|     ..:::.|  :.:|||..|:.||:.||::|..:...|....::||..   |:|:
  Fly   374 LNDFTFTGLFNLGKFDTPLKFDYFELPIFMILGVTGGLLGAAWNSLNTKINKFRKRFIPWKIGK- 437

  Fly   505 PVMEVLFVTLV-TAIICYPNPFTRMNMNELIFLLVSKCSP--GDVT-NPL---CDYKRMNITSGN 562
             |:|.:.|.:: ..:.|            |:...::.|.|  .|.| ||:   |:....|..:..
  Fly   438 -VLEAVVVAMMGVTLAC------------LMIYFINDCRPLGNDPTNNPVQLFCEDNEYNAVAAL 489

  Fly   563 SF--IEVT------EPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIV 619
            .|  .|.|      :| ||.:..:.|.:.| ::...|:..|||:.|..|:|||:.|:||..||::
  Fly   490 WFQTPEATVRSLFHDP-PGSHKILTLALFT-VVYYVLSCATFGLNVSLGVFIPTALVGAAWGRLL 552

  Fly   620 GIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTG-GVRY 683
            .:   ...|.:|...|          :.||.||::||||.||||.|||:||.||:.|.|| ...:
  Fly   553 AM---LTYYVFPQAEF----------LHPGKYALIGAAANLGGVLRMTISLSVILMETTGVETSF 604

  Fly   684 IVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFL------DSKEEFAHTTLAADVMQPKRNET 742
            ..||:.|.:::|||||.. .:||||..|.:|..|.|      ..|...|...|:..|:..|..::
  Fly   605 FFPLIIALISAKWVGDYF-NEGIYDTQIQVNHVPMLTWEPLPQYKGLKAREILSKPVICIKIRDS 668

  Fly   743 LNVITQDSMTVDDVENLLKETEHNGYPVVVS-----RENQYLVGFVLRRDL------NLAIGNAK 796
            .|.|.:          :||:.:|||:|||..     |....:.|.:||..|      :|.:.| |
  Fly   669 ANYIYE----------MLKKCDHNGFPVVDDVCGDRRSEGRVCGIILRSQLIVILLKSLYVEN-K 722

  Fly   797 RLIEGISSSSIVLFTSSQP----IQNLGPQPLKLKKILDM------APITVTDQTPMETVVDMFR 851
            |.  .:..:||..|....|    |:::.....|:...:|:      :||.|.....:..:..:||
  Fly   723 RF--WLPETSIQTFRDLYPRFPSIKSVRKLDEKINYTVDLSMFMNPSPIRVNPHDSVPRIFQIFR 785

  Fly   852 KLGLRQTLV-THNGRLLGVITKKDVL 876
            .||||..|| .|..|:.|:||::|.:
  Fly   786 ALGLRHLLVINHENRIAGIITRRDFI 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	164/541 (30%)
		Voltage_CLC	298..699	CDD:279048	139/438 (32%)
		CBS	738..876	CDD:223591	44/159 (28%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	43/158 (27%)
ClC-b	NP_610798.1	CBS_pair_EriC_assoc_euk_bac	674..811	CDD:239964	41/149 (28%)
		ClC_6_like	115..639	CDD:239657	177/606 (29%)
		Voltage_CLC	213..620	CDD:279048	139/436 (32%)
		CBS	653..811	CDD:223591	46/170 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460702
Domainoid	1	1.000	102	1.000	Domainoid score	I344
eggNOG	1	0.900	-	-		E1_COG0038
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	87	1.000	Inparanoid score	I348
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D15659at33392
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.800