Protein Alignment ClC-c and Clcn6

DIOPT Version :10

• Sequence 1: NP_730105.3
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_001099949.1
• Gene: Clcn6 / 295586
• RGDID: 1305379
• Length: 870
• Species: Rattus norvegicus
• Alignment Length: 925
• Identity: 253/925 - (27%)
• Similarity: 370/925 - (40%)
• Gaps: 294/925 - (31%)

  Fly   146 LSFYGSSDVQDD--IPGIGQYEDFHTIDWQRDIARDRMRHRYI-VKKRQDSLWDLIKGSIDAGSG 207
            |:..|.:..::|  :|    .:|:.::|:.|.|     ...|: |.:..|:.    ||.......
  Rat    29 LTILGETQEEEDEILP----RKDYESLDYDRCI-----NDPYLEVLETMDNK----KGRRHEAVK 80

  Fly   208 WLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWP 272
            |:.|..:|:..|.|...||......:.||.|:...:.    |:|         .:..|......
  Rat    81 WMVVFAIGVCTGLVGLFVDFSVRLFTQLKFGVVQTSV----EEC---------SQKGCLALSLL- 131

  Fly   273 EIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGK 337
            |:.|.:                  |.|..| |||:.:..|.|.||||||||..|:|..:.|.:..
  Rat   132 ELLGFN------------------LTFVFL-ASLLVLIEPVAAGSGIPEIKCYLNGVKVPGIVRL 177

  Fly   338 WTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIG---NIFSHV--------FPKYGRNEAKKREI 391
            .|||.|..|::.||:.||.:||||||:|..:.:|   ..|..:        || |.|::..||:.
  Rat   178 RTLLCKVFGVLFSVAGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFP-YFRSDRDKRDF 241

  Fly   392 LSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVL---RSLTPFGNEHS- 452
            :||.|||||:.||||||||.||||||.|.::.....|:..||::.|.|.|   ||...||:..:
  Rat   242 VSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGAF 306

  Fly   453 ----VLFFVEYN--------KPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFS-----K 500
                :|.|.|:.        ..|...:|..||.:|::||::|..|...|....:||..:     |
  Rat   307 QLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPK 371

  Fly   501 LGQYPVMEVLFVTLVTAII----------CYPNPFTRMNMNELIFLLVSK-----------CSPG 544
            |.:  |:|.|.|:|||.::          |.....|....|....|.|:.           | |.
  Rat   372 LVR--VLESLLVSLVTTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKTFFC-PN 433

  Fly   545 DVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSL 609
            |..|   |...:...|..|.|.......|.:|.: .|.|.|.|...:..:|||..||:|||:|||
  Rat   434 DTYN---DMATLFFNSQESAILQLFHQDGTFSPV-TLALFFALYFLMACWTFGTSVPSGLFVPSL 494

  Fly   610 LLGAIMGRIV--------GIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRM 666
            |.||..||:|        |:|   ..||                   |.:|::||||.||||.||
  Rat   495 LCGAAFGRLVANVLKSYIGLG---HLYS-------------------GTFALIGAAAFLGGVVRM 537

  Fly   667 TVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEFAHTTL- 730
            |:||.||:.|.|..:.|.:|:|...|.:||.||...: ||||.||.|.|.|.|:.:.|.....|
  Rat   538 TISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNK-GIYDIHIGLRGVPLLEWETEVEMDRLR 601

  Fly   731 AADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNA 795
            |:|:|:|  |.|   .......:..:.::|:.|.|:.:|||.  ||:               ||.
  Rat   602 ASDIMEP--NLT---YVYPHTRIQSLVSILRTTVHHAFPVVT--ENR---------------GNE 644

  Fly   796 KRLIEG---------ISSSSIVL--------------FTSSQ----------------------- 814
            |..::|         ...|||:.              :.||:
  Rat   645 KEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPSSELRNVCDEHVASEEPAEKEDLLQQ 709

  Fly   815 -------PIQNLGP----------------------------------------------QP--- 823
                   |..||.|                                              ||
  Rat   710 MLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRSQLVTLLVRGVCYSESQSSASQPRLS 774

  Fly   824 ---------------------LKLKKILDM------APITVTDQTPMETVVDMFRKLGLRQ-TLV 860
                                 |..:.|:|:      :|.||:..|.:..|.::||.:|||. .:|
  Rat   775 YAEMAEDYPRFPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVV 839

  Fly   861 THNGRLLGVITKKDV 875
            ...|.::|:||:.::
  Rat   840 NAVGEIVGIITRHNL 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_730105.3	ClC_3_like	215..719	CDD:239656	188/564 (33%)
		CBS_pair_voltage-gated_CLC_euk_bac	730..878	CDD:341367	48/277 (17%)
		CBS repeat	736..829	CDD:341367	27/215 (13%)
		CBS repeat	835..877	CDD:341367	14/42 (33%)
Clcn6	NP_001099949.1	ClC_6_like	49..589	CDD:239657	198/612 (32%)
		CBS_pair_voltage-gated_CLC_euk_bac	601..854	CDD:341367	47/274 (17%)
		CBS repeat	607..807	CDD:341367	29/221 (13%)
		CBS repeat	813..854	CDD:341367	14/40 (35%)