DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and Clcn6

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001099949.1	Gene:	Clcn6 / 295586	RGDID:	1305379	Length:	870	Species:	Rattus norvegicus

Alignment Length:	925	Identity:	253/925 - (27%)
Similarity:	370/925 - (40%)	Gaps:	294/925 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 LSFYGSSDVQDD--IPGIGQYEDFHTIDWQRDIARDRMRHRYI-VKKRQDSLWDLIKGSIDAGSG 207
            |:..|.:..::|  :|    .:|:.::|:.|.|     ...|: |.:..|:.    ||.......
  Rat    29 LTILGETQEEEDEILP----RKDYESLDYDRCI-----NDPYLEVLETMDNK----KGRRHEAVK 80

  Fly   208 WLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWP 272
            |:.|..:|:..|.|...||......:.||.|:...:.    |:|         .:..|......
  Rat    81 WMVVFAIGVCTGLVGLFVDFSVRLFTQLKFGVVQTSV----EEC---------SQKGCLALSLL- 131

  Fly   273 EIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGK 337
            |:.|.:                  |.|..| |||:.:..|.|.||||||||..|:|..:.|.:..
  Rat   132 ELLGFN------------------LTFVFL-ASLLVLIEPVAAGSGIPEIKCYLNGVKVPGIVRL 177

  Fly   338 WTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIG---NIFSHV--------FPKYGRNEAKKREI 391
            .|||.|..|::.||:.||.:||||||:|..:.:|   ..|..:        || |.|::..||:.
  Rat   178 RTLLCKVFGVLFSVAGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFP-YFRSDRDKRDF 241

  Fly   392 LSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVL---RSLTPFGNEHS- 452
            :||.|||||:.||||||||.||||||.|.::.....|:..||::.|.|.|   ||...||:..:
  Rat   242 VSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGAF 306

  Fly   453 ----VLFFVEYN--------KPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFS-----K 500
                :|.|.|:.        ..|...:|..||.:|::||::|..|...|....:||..:     |
  Rat   307 QLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPK 371

  Fly   501 LGQYPVMEVLFVTLVTAII----------CYPNPFTRMNMNELIFLLVSK-----------CSPG 544
            |.:  |:|.|.|:|||.::          |.....|....|....|.|:.           | |.
  Rat   372 LVR--VLESLLVSLVTTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKTFFC-PN 433

  Fly   545 DVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSL 609
            |..|   |...:...|..|.|.......|.:|.: .|.|.|.|...:..:|||..||:|||:|||
  Rat   434 DTYN---DMATLFFNSQESAILQLFHQDGTFSPV-TLALFFALYFLMACWTFGTSVPSGLFVPSL 494

  Fly   610 LLGAIMGRIV--------GIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRM 666
            |.||..||:|        |:|   ..||                   |.:|::||||.||||.||
  Rat   495 LCGAAFGRLVANVLKSYIGLG---HLYS-------------------GTFALIGAAAFLGGVVRM 537

  Fly   667 TVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEFAHTTL- 730
            |:||.||:.|.|..:.|.:|:|...|.:||.||...: ||||.||.|.|.|.|:.:.|.....|
  Rat   538 TISLTVILIESTNEITYGLPIMVTLMVAKWTGDFFNK-GIYDIHIGLRGVPLLEWETEVEMDRLR 601

  Fly   731 AADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNA 795
            |:|:|:|  |.|   .......:..:.::|:.|.|:.:|||.  ||:               ||.
  Rat   602 ASDIMEP--NLT---YVYPHTRIQSLVSILRTTVHHAFPVVT--ENR---------------GNE 644

  Fly   796 KRLIEG---------ISSSSIVL--------------FTSSQ----------------------- 814
            |..::|         ...|||:.              :.||:
  Rat   645 KEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPSSELRNVCDEHVASEEPAEKEDLLQQ 709

  Fly   815 -------PIQNLGP----------------------------------------------QP--- 823
                   |..||.|                                              ||
  Rat   710 MLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRSQLVTLLVRGVCYSESQSSASQPRLS 774

  Fly   824 ---------------------LKLKKILDM------APITVTDQTPMETVVDMFRKLGLRQ-TLV 860
                                 |..:.|:|:      :|.||:..|.:..|.::||.:|||. .:|
  Rat   775 YAEMAEDYPRFPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVV 839

  Fly   861 THNGRLLGVITKKDV 875
            ...|.::|:||:.::
  Rat   840 NAVGEIVGIITRHNL 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	188/564 (33%)
		Voltage_CLC	298..699	CDD:279048	163/461 (35%)
		CBS	738..876	CDD:223591	43/268 (16%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	42/265 (16%)
Clcn6	NP_001099949.1	ClC_6_like	49..589	CDD:239657	198/612 (32%)
		Voltage_CLC	140..571	CDD:279048	164/461 (36%)
		CBS	609..656	CDD:214522	14/66 (21%)
		CBS_pair_EriC_assoc_euk_bac	<801..854	CDD:239964	17/52 (33%)
		CBS	804..>854	CDD:223591	15/49 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348880
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.740