DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and Clcn7

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_113756.1	Gene:	Clcn7 / 29233	RGDID:	61836	Length:	803	Species:	Rattus norvegicus

Alignment Length:	745	Identity:	228/745 - (30%)
Similarity:	344/745 - (46%)	Gaps:	155/745 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 WLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSV---FEEGNCSTWK 269
            |:...|:||..|.||..:||....::.||:.:               .|.::   .|:|..|
  Rat   125 WVICALIGILTGLVACFIDIVVENLAGLKYRV---------------IKDNIDKFTEKGGLS--- 171

  Fly   270 TWPEIFGLDRNGTGPYIVAYIWYVLWALL---FASLSASLVRMFAPYACGSGIPEIKTILSGFII 331
                 |.|               :|||.|   |..:.:.:|....|.|.|||||:||..|:|..|
  Rat   172 -----FSL---------------LLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKI 216

  Fly   332 RGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSH-----------VFPKYGRNE 385
            ...:...||:||..|::|||..||.:||||||:|..|.|....|.           :| :|.|.:
  Rat   217 PHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIF-EYFRRD 280

  Fly   386 AKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLR-------- 442
            .:||:.:||.||||||.|||||:|||||||||.:.::.....||.||.::|:.|.|.
  Rat   281 TEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHG 345

  Fly   443 --------SLTPFGNEHSVLFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYR-KF 498
                    .|..||.      |......:...|:..|:.:|::||::|..|...|.|...:| ::
  Rat   346 NMWDLSSPGLINFGR------FDSEKMAYTIHEIPVFIAMGVVGGILGAVFNALNYWLTMFRIRY 404

  Fly   499 SKLGQYPVMEVLFVTLVTAII----------CYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDY 553
            .......|:|.:.|..|||.:          |.|...:.|:....:|     |:.|:..:....:
  Rat   405 IHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSYPLQLF-----CADGEYNSMAAAF 464

  Fly   554 KRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRI 618
            ..   |...|.:.:....||.|:.:.|.:.|.:. ..|..:|:|:.|.||:||||||:||..||:
  Rat   465 FN---TPEKSVVSLFHDPPGSYNPMTLGLFTLVY-FFLACWTYGLTVSAGVFIPSLLIGAAWGRL 525

  Fly   619 VGIGVEQFAYSYPNIWFFTGEC--ADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGV 681
            .||.:.          :.||..  ||     ||.||::||||.|||:.|||:||.|||.|.|..|
  Rat   526 FGISMS----------YLTGAAIWAD-----PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNV 575

  Fly   682 RYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEF-AHTTLAADVMQP-----KRN 740
            .|..|:|...|.:|.|||.. .:|:||.||.|...|||..:... :|:..|.:||..     :|.
  Rat   576 TYGFPIMLVLMTAKIVGDVF-IEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRR 639

  Fly   741 ETLNVITQDSMTVDDVENLLKET--EHNGYPVVV---SRENQYLVGFVLRRDLNLAIGNAKRLIE 800
            |.:.:|.          ::|.:|  .|||:|||.   ..:...|.|.:||..| :.:...|..:|
  Rat   640 EKVGIIV----------DVLSDTASNHNGFPVVEDVGDTQPARLQGLILRSQL-IVLLKHKVFVE 693

  Fly   801 ----GISSSSIVL------FTSSQPIQNLGPQ------PLKLKKILDMAPITVTDQTPMETVVDM 849
                |:....:.|      :....|||::...      .:.|.:.::.:|.||..:..:..|..:
  Rat   694 RSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKL 758

  Fly   850 FRKLGLRQTLVTHN-GRLLGVITKKDVLRH 878
            ||.||||..:|..| .:::|::|:||:.|:
  Rat   759 FRALGLRHLVVVDNHNQVVGLVTRKDLARY 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	179/549 (33%)
		Voltage_CLC	298..699	CDD:279048	152/443 (34%)
		CBS	738..876	CDD:223591	40/159 (25%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	39/158 (25%)
Clcn7	NP_113756.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		ClC_6_like	93..618	CDD:239657	183/562 (33%)
		Voltage_CLC	183..593	CDD:279048	151/440 (34%)
		Selectivity filter part_1. /evidence=ECO:0000250	201..205		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	243..247		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	510..514		2/3 (67%)
		CBS_pair_EriC_assoc_euk_bac	634..788	CDD:239964	40/164 (24%)
		CBS	736..>793	CDD:223591	17/53 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810