DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-c and Clcn2

DIOPT Version :10

Sequence 1:NP_730105.3 Gene:ClC-c / 39759 FlyBaseID:FBgn0036566 Length:893 Species:Drosophila melanogaster
Sequence 2:NP_058833.1 Gene:Clcn2 / 29232 RGDID:2361 Length:907 Species:Rattus norvegicus


Alignment Length:843 Identity:216/843 - (25%)
Similarity:347/843 - (41%) Gaps:224/843 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 HRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPA-FWF 246
            |:::|.:              .|..|:.::|:|:....|        ||..|....:|..| .|.
  Rat    86 HKFLVSR--------------VGEDWIFLVLLGLLMALV--------SWAMDYAIAVCLQAQQWM 128

  Fly   247 NREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFA 311
            :|                           ||:.|    .::.|:.:|.:.::..:.||...::.|
  Rat   129 SR---------------------------GLNTN----ILLQYLAWVTYPVVLITFSAGFTQILA 162

  Fly   312 PYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSH 376
            |.|.||||||:||||.|.:::.||...|.:.|.:||..::.:|:.||||||.|||||....:.|.
  Rat   163 PQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSK 227

  Fly   377 VFPKYG---RNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAA 438
            ....:|   .||::..|:|:||.|.||...|.|||||||||:|..|.:|.::..||.||.|..:|
  Rat   228 FLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSA 292

  Fly   439 FVLRSLTPFGNEH---SVLFFVEY--NKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCR-YRK 497
            |:.|.|..:..:.   :.||...:  :.|:...||..|..:||..|..|..|:..|....: .||
  Rat   293 FIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRK 357

  Fly   498 FSKLGQYPVME-VLFVTLVTAII---CYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCD---YKR 555
            ...:.::.:.: :||..|||.:|   .:|..|.:....:|        |..:....|.|   :.|
  Rat   358 QKTINRFLMKKRLLFPALVTLLISTLTFPPGFGQFMAGQL--------SQKETLVTLFDNRTWVR 414

  Fly   556 MNITSGNSFIEVTEPGPGVYSSIWLLMLTFIL-KLALTIFTFGMKVPAGLFIPSLLLGAIMGRIV 619
            ..:.........::......::::|.::.||| |..::.....:.||.|.|:|..::||..||:|
  Rat   415 QGLVEDLGAPSTSQAWSPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLV 479

  Fly   620 GIGVEQFAYSYPNIWFFTGECADSNL--ITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVR 682
            |   |..|     .||..|...||:.  |.||.||||||||:.|.||. |||..||:|||||.:.
  Rat   480 G---ESMA-----AWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH-TVSTAVIVFELTGQIA 535

  Fly   683 YIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPKRNETLNVIT 747
            :|:|:|.|.:.:..|..:| :..:||:.|.:...|:|.......|        |..|....:::.
  Rat   536 HILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGRH--------QQYRVRVEDIMV 591

  Fly   748 QD------SMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIG------------- 793
            :|      |.|..|:...|..|:.....:|.|.|:..|:|.:.|..:...:|             
  Rat   592 RDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQ 656

  Fly   794 ------------------------------------------------------NAKRLIEG--- 801
                                                                  ||..|.||   
  Rat   657 KLRKAQMSPPSDQESPPSSETSIRFQVNTEDSGFPGAHGQTHKPLKPALKRGPSNATSLQEGTTG 721

  Fly   802 -ISSSSIV---LFTSSQPIQNLGPQ--------PLKLKKI------------------------- 829
             :.|:.|.   ||..|.|:::...:        ..|||::                         
  Rat   722 NMESAGIALRSLFCGSPPLESTTSELEKSESCDKRKLKRVRISLASDSDLEGKMSPEEILEWEEQ 786

  Fly   830 ------------LDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVK 880
                        :|.||..:.::|.:.....:|..||:....||..|||:|::|.|::.:.::
  Rat   787 QLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIE 849

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
ClC-cNP_730105.3 ClC_3_like 215..719 CDD:239656 165/523 (32%)
CBS_pair_voltage-gated_CLC_euk_bac 730..878 CDD:341367 44/272 (16%)
CBS repeat 736..829 CDD:341367 29/180 (16%)
CBS repeat 835..877 CDD:341367 12/41 (29%)
Clcn2NP_058833.1 Essential for channel gating by both voltage and cell volume. /evidence=ECO:0000269|PubMed:1334533 22..40
Modulates channel gating by both voltage and cell volume. /evidence=ECO:0000269|PubMed:1334533 42..55
ClC_1_like 96..573 CDD:239655 168/533 (32%)
Selectivity filter part_1. /evidence=ECO:0000250 167..171 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 209..213 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 463..467 2/3 (67%)
CBS_pair_voltage-gated_CLC_euk_bac 585..847 CDD:341367 42/261 (16%)
CBS repeat 591..798 CDD:341367 27/206 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 650..720 5/69 (7%)
CBS repeat 804..846 CDD:341367 12/41 (29%)