DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and Clcn2

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_058833.1	Gene:	Clcn2 / 29232	RGDID:	2361	Length:	907	Species:	Rattus norvegicus

Alignment Length:	843	Identity:	216/843 - (25%)
Similarity:	347/843 - (41%)	Gaps:	224/843 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 HRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPA-FWF 246
            |:::|.:              .|..|:.::|:|:....|        ||..|....:|..| .|.
  Rat    86 HKFLVSR--------------VGEDWIFLVLLGLLMALV--------SWAMDYAIAVCLQAQQWM 128

  Fly   247 NREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFA 311
            :|                           ||:.|    .::.|:.:|.:.::..:.||...::.|
  Rat   129 SR---------------------------GLNTN----ILLQYLAWVTYPVVLITFSAGFTQILA 162

  Fly   312 PYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSH 376
            |.|.||||||:||||.|.:::.||...|.:.|.:||..::.:|:.||||||.|||||....:.|.
  Rat   163 PQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLSK 227

  Fly   377 VFPKYG---RNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAA 438
            ....:|   .||::..|:|:||.|.||...|.|||||||||:|..|.:|.::..||.||.|..:|
  Rat   228 FLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFSA 292

  Fly   439 FVLRSLTPFGNEH---SVLFFVEY--NKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCR-YRK 497
            |:.|.|..:..:.   :.||...:  :.|:...||..|..:||..|..|..|:..|....: .||
  Rat   293 FIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMRK 357

  Fly   498 FSKLGQYPVME-VLFVTLVTAII---CYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCD---YKR 555
            ...:.::.:.: :||..|||.:|   .:|..|.:....:|        |..:....|.|   :.|
  Rat   358 QKTINRFLMKKRLLFPALVTLLISTLTFPPGFGQFMAGQL--------SQKETLVTLFDNRTWVR 414

  Fly   556 MNITSGNSFIEVTEPGPGVYSSIWLLMLTFIL-KLALTIFTFGMKVPAGLFIPSLLLGAIMGRIV 619
            ..:.........::......::::|.::.||| |..::.....:.||.|.|:|..::||..||:|
  Rat   415 QGLVEDLGAPSTSQAWSPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLV 479

  Fly   620 GIGVEQFAYSYPNIWFFTGECADSNL--ITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVR 682
            |   |..|     .||..|...||:.  |.||.||||||||:.|.||. |||..||:|||||.:.
  Rat   480 G---ESMA-----AWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH-TVSTAVIVFELTGQIA 535

  Fly   683 YIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPKRNETLNVIT 747
            :|:|:|.|.:.:..|..:| :..:||:.|.:...|:|.......|        |..|....:::.
  Rat   536 HILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGRH--------QQYRVRVEDIMV 591

  Fly   748 QD------SMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIG------------- 793
            :|      |.|..|:...|..|:.....:|.|.|:..|:|.:.|..:...:|
  Rat   592 RDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHMQ 656

  Fly   794 ------------------------------------------------------NAKRLIEG--- 801
                                                                  ||..|.||
  Rat   657 KLRKAQMSPPSDQESPPSSETSIRFQVNTEDSGFPGAHGQTHKPLKPALKRGPSNATSLQEGTTG 721

  Fly   802 -ISSSSIV---LFTSSQPIQNLGPQ--------PLKLKKI------------------------- 829
             :.|:.|.   ||..|.|:::...:        ..|||::
  Rat   722 NMESAGIALRSLFCGSPPLESTTSELEKSESCDKRKLKRVRISLASDSDLEGKMSPEEILEWEEQ 786

  Fly   830 ------------LDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVK 880
                        :|.||..:.::|.:.....:|..||:....||..|||:|::|.|::.:.::
  Rat   787 QLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIE 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	165/523 (32%)
		Voltage_CLC	298..699	CDD:279048	146/419 (35%)
		CBS	738..876	CDD:223591	43/262 (16%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	42/261 (16%)
Clcn2	NP_058833.1	ClC_1_like	96..573	CDD:239655	168/533 (32%)
		Voltage_CLC	149..552	CDD:279048	146/419 (35%)
		Selectivity filter part_1. /evidence=ECO:0000250	167..171		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	209..213		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	463..467		2/3 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..720		5/69 (7%)
		CBS_pair_EriC_assoc_euk_bac	<799..847	CDD:239964	15/47 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	865..907
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348875
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740