DRSC/TRiP Functional Genomics Resources

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Protein Alignment ClC-c and Clcn6

DIOPT Version :9

Sequence 1:NP_001261922.1 Gene:ClC-c / 39759 FlyBaseID:FBgn0036566 Length:893 Species:Drosophila melanogaster
Sequence 2:NP_036059.1 Gene:Clcn6 / 26372 MGIID:1347049 Length:870 Species:Mus musculus


Alignment Length:930 Identity:254/930 - (27%)
Similarity:373/930 - (40%) Gaps:292/930 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   146 LSFYGSSDVQDD--IPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGSGW 208
            |:..|.:..::|  :|    .:|:.::|:.|.|....:.....:..::...::.:|        |
Mouse    29 LTILGETQEEEDEILP----RKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVK--------W 81

  Fly   209 LCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWPE 273
            :.|..:|:..|.|...||......:.||.|:...:.    |:|         .:..|...... |
Mouse    82 MVVFAIGVCTGLVGLFVDFSVRLFTQLKFGVVQTSV----EEC---------SQKGCLALSLL-E 132

  Fly   274 IFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKW 338
            :.|.:                  |.|..| |||:.:..|.|.||||||||..|:|..:.|.:...
Mouse   133 LLGFN------------------LTFVFL-ASLLVLIEPVAAGSGIPEIKCYLNGVKVPGIVRLR 178

  Fly   339 TLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIG---NIFSHV--------FPKYGRNEAKKREIL 392
            |||.|..|::.|||.||.:||||||:|..:.:|   ..|..:        || |.|::..||:.:
Mouse   179 TLLCKVFGVLFSVSGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFP-YFRSDRDKRDFV 242

  Fly   393 SAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVL---RSLTPFGNEHS-- 452
            ||.|||||:.||||||||.||||||.|.::.....|:..||::.|.|.|   ||...||:..|  
Mouse   243 SAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQ 307

  Fly   453 ---VLFFVEYN--------KPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFS-----KL 501
               :|.|.|:.        ..|...:|..||.:|::||::|..|...|....:||..:     ||
Mouse   308 LPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKL 372

  Fly   502 GQYPVMEVLFVTLVTAII----------CYPNPFTRMNMNELIFLLVSK-----------CSPGD 545
            .:  |:|.|.|:|||.::          |.....|....|....|.|:.           | |.|
Mouse   373 VR--VLESLLVSLVTTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKAFFC-PND 434

  Fly   546 VTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLL 610
            ..|   |...:...|..|.|.......|.:|.: .|.|.|||...|..:|||..||:|||:||||
Mouse   435 TYN---DMATLFFNSQESAILQLFHQDGTFSPV-TLALFFILYFLLACWTFGTSVPSGLFVPSLL 495

  Fly   611 LGAIMGRIV--------GIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRMT 667
            .||..||:|        |:|   ..||                   |.:|::||||.||||.|||
Mouse   496 CGAAFGRLVANVLKSYIGLG---HLYS-------------------GTFALIGAAAFLGGVVRMT 538

  Fly   668 VSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEFAHTTL-A 731
            :||.||:.|.|..:.|.:|:|...|.:||.|| |..:||||.||.|.|.|.|:.:.:.....| |
Mouse   539 ISLTVILIESTNEITYGLPIMVTLMVAKWTGD-LFNKGIYDVHIGLRGVPLLEWETDVEMDKLRA 602

  Fly   732 ADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNAK 796
            :|:|:|  |.|   .......:..:.::|:.|.|:.:|||.  ||:               ||.|
Mouse   603 SDIMEP--NLT---YVYPHTRIQSLVSILRTTVHHAFPVVT--ENR---------------GNEK 645

  Fly   797 RLIEG---------ISSSSIVL--------------FTSSQ------------------------ 814
            ..::|         ...|||:.              :.||:                        
Mouse   646 EFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPSSELRNVCDEHVASEEPAEKEDLLQQM 710

  Fly   815 ------PIQNLGP----------------------------------------------QP---- 823
                  |..||.|                                              ||    
Mouse   711 LERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRSQLVTLLVRGVCYSESQSSASQPRLSY 775

  Fly   824 --------------------LKLKKILDM------APITVTDQTPMETVVDMFRKLGLRQ-TLVT 861
                                |..:.|:|:      :|.||:..|.:..|.::||.:|||. .:|.
Mouse   776 AEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVN 840

  Fly   862 HNGRLLGVITKKDVLRHVKQ 881
            ..|.::|:||:.::.....|
Mouse   841 AVGEIVGIITRHNLTNEFLQ 860

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ClC-cNP_001261922.1 ClC_3_like 215..719 CDD:239656 193/564 (34%)
Voltage_CLC 298..699 CDD:279048 167/461 (36%)
CBS 738..876 CDD:223591 43/267 (16%)
CBS_pair_EriC_assoc_euk_bac 741..878 CDD:239964 42/266 (16%)
Clcn6NP_036059.1 ClC_6_like 49..589 CDD:239657 199/611 (33%)
Voltage_CLC 140..571 CDD:279048 169/462 (37%)
Selectivity filter part_1. /evidence=ECO:0000250 156..160 3/3 (100%)
Selectivity filter part_2. /evidence=ECO:0000250 198..202 3/3 (100%)
Selectivity filter part_3. /evidence=ECO:0000250 488..492 3/3 (100%)
CBS 609..656 CDD:214522 14/66 (21%)
CBS_pair_EriC_assoc_euk_bac <801..854 CDD:239964 17/52 (33%)
CBS 804..>854 CDD:223591 15/49 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167845470
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000220
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.840

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