DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and Clcn5

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_038955439.1	Gene:	Clcn5 / 25749	RGDID:	2362	Length:	816	Species:	Rattus norvegicus

Alignment Length:	833	Identity:	483/833 - (57%)
Similarity:	608/833 - (72%)	Gaps:	43/833 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AGTDDEDMIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNHHNQRTMH 129
            :.:.|||::||     ||..:...         .|:.....|.|.: |:...||||...:.|.|
  Rat    23 SSSSDEDLMDI-----PGTAMDFS---------MRDDVPPLDREIE-GNKSYNGGGIGSSNRIM- 71

  Fly   130 QHVPTHSAFGDPMDGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSL 194
                                  ..:::.|||:|.|:||:||||.|:.:|||.|||.|..|.::|.
  Rat    72 ----------------------DFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKEST 114

  Fly   195 WDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSV 259
            |.||....||.||||.:||:|:.:|.:||::||.|.||:|||.|||...||||.|.||:.::...
  Rat   115 WALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVT 179

  Fly   260 FEE-GNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIK 323
            ||: ..|..|.:|.::......|...|||.|..|||||||||.|:.|||:.||||||||||||||
  Rat   180 FEDRDKCPEWNSWSQLIISTDQGAFAYIVNYFMYVLWALLFAFLAVSLVKAFAPYACGSGIPEIK 244

  Fly   324 TILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYGRNEAKK 388
            |||||||||||||||||:||::.|:|:||:||:||||||:||:|.|.|||..|.|.||.:||||:
  Rat   245 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKR 309

  Fly   389 REILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSV 453
            ||:|||||||||||||||||||||||||||||||||||||||||.||:|||.|||:.||||...|
  Rat   310 REVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLV 374

  Fly   454 LFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVLFVTLVTAI 518
            ||:||::.||..|||:||:.|||.||:.|..||:.|:.|||.||.::||:|||:|||.||.:|||
  Rat   375 LFYVEFHTPWHLFELVPFIVLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVVEVLIVTAITAI 439

  Fly   519 ICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLML 583
            :.:||.:|||:.:|||..|.:.|...| ::.||||:....||....:.....|.||||::|.|.|
  Rat   440 LAFPNEYTRMSTSELISELFNDCGLLD-SSKLCDYENHFNTSKGGELPDRPAGVGVYSAMWQLAL 503

  Fly   584 TFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECAD-SNLIT 647
            |.|||:.:||||||||:|:||||||:.:|||.||::|:|:||.||.:.:...|...|:. ::.||
  Rat   504 TLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGIFNSWCSQGADCIT 568

  Fly   648 PGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIA 712
            |||||:|||||.|||||||||||||||||||||:.||||||||||.||||.|||||:|||||||.
  Rat   569 PGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIR 633

  Fly   713 LNGYPFLDSKEEFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDVENLLKETEHNGYPVVVSREN 776
            |||||||::||||||.|||.|||:|:||: .|.|:|||||||:|||.::.||.::|:|||||||:
  Rat   634 LNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRES 698

  Fly   777 QYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLFTS-SQPIQNLGPQPLKLKKILDMAPITVTDQ 840
            |.||||||||||.::|.||::..:|:.|:||:.||. |.|:....|..|||:.|||::|.||||.
  Rat   699 QRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPMPPYTPPTLKLRNILDLSPFTVTDL 763

  Fly   841 TPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQMDNEDPNTVLFN 893
            ||||.|||:||||||||.||||||||||:|||||||:|:.||.|:||.::|||
  Rat   764 TPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPESILFN 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	320/505 (63%)
		Voltage_CLC	298..699	CDD:279048	265/401 (66%)
		CBS	738..876	CDD:223591	88/139 (63%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	88/138 (64%)
Clcn5	XP_038955439.1	ClC_3_like	142..640	CDD:239656	318/498 (64%)
		CBS_pair_voltage-gated_CLC_euk_bac	651..801	CDD:341367	96/149 (64%)
		CBS repeat	657..752	CDD:341367	51/94 (54%)
		CBS repeat	758..800	CDD:341367	35/41 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348877
Domainoid	1	1.000	546	1.000	Domainoid score	I251
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	964	1.000	Inparanoid score	I310
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D116173at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		otm45379
orthoMCL	1	0.900	-	-		OOG6_100336
Panther	1	1.100	-	-	LDO	PTHR45711
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X829
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810