DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and SPBC887.02

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_596476.2	Gene:	SPBC887.02 / 2541132	PomBaseID:	SPBC887.02	Length:	696	Species:	Schizosaccharomyces pombe

Alignment Length:	769	Identity:	209/769 - (27%)
Similarity:	360/769 - (46%)	Gaps:	138/769 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 EDFHTIDW-------QRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVA 222
            :|...|||       |:...|...|.|::..:.:.|:..:|.               ||..|..|
pombe     2 KDDQLIDWIHERYEEQKSANRLAGRFRFLGLETKYSIISIIS---------------GIFIGLTA 51

  Fly   223 GMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIV 287
            .:::..||.::..:.|.|.....|:::.||    .::.|:..|..:..|       ||....::.
pombe    52 ALLNALASLLNSFREGYCTVNILFDKQTCC----STLTEDYECQEFFFW-------RNNHSVFVS 105

  Fly   288 AYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGF---IIRGYLGKWTLLIKSVGLML 349
            ..| ||..::.||.::.:|..:.||.|..||||.||.||||:   .:..:....||..||:.:..
pombe   106 CLI-YVSVSVGFAFIATTLGYVVAPAARASGIPTIKAILSGYKYPDMNVFFSIKTLCSKSLAVCF 169

  Fly   350 SVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFS 414
            ||::||.:|||||.||||:.|..:...:.|....:|...|::|:||.|:|::.:|.||:|||:|:
pombe   170 SVASGLWVGKEGPFVHIATNIIYLVERIAPSLADSEIFTRQLLAAAMASGIAASFNAPVGGVIFA 234

  Fly   415 LEEV-SYYFP---LKTLWRSFFCALIAAFVLRSLTPFGNEHSVLFFVEYNKPWIFFELIPFVFLG 475
            ||:: |..||   ..::|..|.|:..:...|:.:..:..:...|.:|..::.|.:.:.:||:|:.
pombe   235 LEQLASSSFPSLFTGSIWYEFLCSASSVVALQLIRSWHTDVGYLSYVSLDRRWSYKDTLPFIFIS 299

  Fly   476 IMGGVIGTFFIKANLWWCRYRK-FSKLGQYPVMEVLFVTLVTAIICYP---------NPFTRMNM 530
            |:.|.:|:..|..|:.:....| |||:..  |..|:|::|:|::..|.         ||.
pombe   300 ILCGCLGSVLIYLNMKFASKTKGFSKISN--VFFVIFLSLITSLTAYAILGESELLFNPM----- 357

  Fly   531 NELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIW----LLMLTFILKLAL 591
             ||...:::.|||...| .||:                       ::.|    :|..:.:|.|.|
pombe   358 -ELFPQVINSCSPSSST-VLCE-----------------------TTFWVTAIVLFTSALLGLLL 397

  Fly   592 TIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGA 656
            |..|||..:|.|:.:|||.:||.:||.||..::.   .:|            :|....:|.|:|:
pombe   398 TSATFGAAIPTGIIVPSLAIGACIGRAVGTLLKS---RFP------------SLAGTSIYGVIGS 447

  Fly   657 AAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDS 721
            .|.|...||:.|:||||:|||||.:...:|||.|.:.||||.|::....||||.|.....|:..|
pombe   448 IAFLSSTTRLVVALVVILFELTGALNIALPLMLATLISKWVSDSIIETSIYDAWIQFRNIPYFPS 512

  Fly   722 KEEFAHT-TLAADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLR 785
            ......: .|...|..|::...|.:   .|.:::::|..:.::..:.: ||:..:.::..||:.|
pombe   513 SNSLKFSIPLNFPVRSPEQLVRLPI---RSCSIEELERAMHDSSQSFF-VVLKNDTEFFEGFISR 573

  Fly   786 RDLNLAIGNAKRLIEGISSSSIVLFTSSQPIQNLGPQPLKLKKILDMAPI--------------- 835
            ..::       .|:.....||     :.|...|.|..||:...    ||:
pombe   574 NKVS-------ELLNRRPMSS-----NMQTTDNTGLDPLRSAS----APVDSTFDLFDYIHPTTF 622

  Fly   836 TVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQMDNEDPNT 889
            |:...||...::.:|:..|:....:.::|:|.||:||.|::.:.|:......||
pombe   623 TLNYDTPPVLMLKLFKDAGITNLALLNHGKLHGVLTKIDIIEYAKKCKTHTGNT 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	162/524 (31%)
		Voltage_CLC	298..699	CDD:279048	136/421 (32%)
		CBS	738..876	CDD:223591	30/152 (20%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	30/151 (20%)
SPBC887.02	NP_596476.2	ClC_3_like	105..509	CDD:239656	145/451 (32%)
		Voltage_CLC	115..490	CDD:279048	136/421 (32%)
		CBS_pair	541..665	CDD:239067	28/140 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55339
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100336
Panther	1	1.100	-	-	LDO	PTHR45711
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.780