DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and clh-6

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_506022.1	Gene:	clh-6 / 179655	WormBaseID:	WBGene00000533	Length:	796	Species:	Caenorhabditis elegans

Alignment Length:	854	Identity:	256/854 - (29%)
Similarity:	391/854 - (45%)	Gaps:	194/854 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   140 DPMDGALSFYGSSDVQ-------------------DDIPGIGQYE----DFHTIDWQRDIARDRM 181
            ||:.|......:|:::                   ||:.....:|    .:.::::  :|:.:|:
Worm    19 DPVSGLERVMSNSNLEHVARQRRRLEEELLFSRQLDDVGRTDSHEALSARYESLNY--EISENRL 81

  Fly   182 RHRYIVKK--RQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAF 244
             :|...||  .|.:||.:.:      :.|....|:|:..|.||..:||...:..|:|..
Worm    82 -YRDAEKKPSHQLTLWRISR------NRWFVCFLIGVFTGLVAAFIDIMVHYSKDIKFN------ 133

  Fly   245 WFNR---EQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWA-----LLFAS 301
            |..:   .:|                        |.::.||   ....:|.|:.|     .:..:
Worm   134 WILKYLLSKC------------------------GEEQRGT---TAGCMWTVMIAWIGYNCVLVT 171

  Fly   302 LSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHI 366
            ::|.||...||.|.|||||:||..|:|..|...:...||:.|:||:..||..||..||||||:|.
Worm   172 IAAILVIYVAPIAGGSGIPQIKCYLNGIAIPEVVRLKTLVSKAVGVACSVGGGLCAGKEGPMIHS 236

  Fly   367 ASCIGNIFSH-----------VFPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSY 420
            .:.:|...|.           :|.:: ||:.:||:.:||.|||||:.|||||||||||||||.:.
Worm   237 GAAVGAGISQGKSYSLGIDFGLFREF-RNDREKRDFVSAGAAAGVAAAFGAPIGGVLFSLEEGAS 300

  Fly   421 YFPLKTLWRSFFCALIAAFVLRSLTPFGNEHS--------VLFFVEYNKPWIFFELIPFVFLGIM 477
            ::.....||.||.|:|::|.:..:..:.|..|        ..|.|..||.:..:|:..|:.:||:
Worm   301 FWNQALTWRMFFSAMISSFTVNWILSWFNGRSGWLSWTGLANFGVFENKDYNIWEIPLFLLIGII 365

  Fly   478 GGVIGTFFIKANLWWCRYRK---FSKLGQYPVMEVLFVTLVTAII----------CYP---NP-F 525
            ||.:|..|...|.....:||   .||||:  :.|.|.|..|:..:          |.|   || .
Worm   366 GGCLGALFNYLNTKLTEFRKKYVSSKLGR--LFECLLVAAVSGFLAFLTIFAIDDCQPIGANPTA 428

  Fly   526 TRMNMNELIFLLVSKCSPGDVT--------NPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLM 582
            |...:|::      .|..|:.:        ||....|.|..:..|||            .:..|:
Worm   429 TSTQINQM------WCKKGEYSAVASLFFQNPEESVKSMFHSPINSF------------GVTTLV 475

  Fly   583 LTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNLIT 647
            :..|....||::|||:.||:|:|||::|.||..||:.||.||:.   :|::   ||       |.
Worm   476 IFGIEYFLLTLWTFGISVPSGVFIPAILTGAAWGRLFGIFVERL---FPSV---TG-------ID 527

  Fly   648 PGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIA 712
            ||.||:.||||.||||.|||:||..|:.|.|..:.:.:|:|...|.:||||| :..:|:|||||.
Worm   528 PGKYALAGAAAQLGGVVRMTISLTAIIMEATKDITFGLPIMLVLMVTKWVGD-MFNEGLYDAHID 591

  Fly   713 LNGYPFLD------SKEEFAHTTLAADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVV 771
            |...|.|.      |:...|...:..||:..:|.|.::.|.:          :|:.|.|:|:|||
Worm   592 LAEVPILGWNPPKMSRNILADRVMRKDVVALERRERVSRIVE----------ILRSTLHHGFPVV 646

  Fly   772 VS-RENQY--------LVGFVLRRDLNLAIGNAKRLIEGISSSSIVL-FTSSQ-------PIQNL 819
            .. .|:.|        |.|::||..|...:.|.....||.|:|::.. |...|       .:..|
Worm   647 DRIEESPYESLPDYGRLKGYILRSQLFKLLENRIFEEEGASNSALPNDFYECQDDDDQMKSVAEL 711

  Fly   820 GPQPLKLKKILDMAPI------TVTDQTPMETVVDMFRKLGLRQTLVTH-NGRLLGVITKKDVLR 877
            |.........||:.|.      .|...|.:..:..:||.||||...|.: :..|.||||:|||.|
Worm   712 GLTNFDESCFLDIEPYMHPHPHRVPLNTSLPFIFRLFRGLGLRYLFVVNDDNHLRGVITRKDVAR 776

  Fly   878 HVKQMDNED 886
            ..::..|.:
Worm   777 FRERRRNRE 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	186/555 (34%)
		Voltage_CLC	298..699	CDD:279048	160/444 (36%)
		CBS	738..876	CDD:223591	45/161 (28%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	45/160 (28%)
clh-6	NP_506022.1	ClC_6_like	70..598	CDD:239657	196/604 (32%)
		Voltage_CLC	168..580	CDD:279048	162/446 (36%)
		CBS_pair_EriC_assoc_euk_bac	620..774	CDD:239964	44/163 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810