Protein Alignment ClC-c and clh-6

DIOPT Version :10

• Sequence 1: NP_730105.3
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_506022.1
• Gene: clh-6 / 179655
• WormBaseID: WBGene00000533
• Length: 796
• Species: Caenorhabditis elegans
• Alignment Length: 854
• Identity: 256/854 - (29%)
• Similarity: 391/854 - (45%)
• Gaps: 194/854 - (22%)

  Fly   140 DPMDGALSFYGSSDVQ-------------------DDIPGIGQYE----DFHTIDWQRDIARDRM 181
            ||:.|......:|:::                   ||:.....:|    .:.::::  :|:.:|:
 Worm    19 DPVSGLERVMSNSNLEHVARQRRRLEEELLFSRQLDDVGRTDSHEALSARYESLNY--EISENRL 81

  Fly   182 RHRYIVKK--RQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAF 244
             :|...||  .|.:||.:.:      :.|....|:|:..|.||..:||...:..|:|..
 Worm    82 -YRDAEKKPSHQLTLWRISR------NRWFVCFLIGVFTGLVAAFIDIMVHYSKDIKFN------ 133

  Fly   245 WFNR---EQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWA-----LLFAS 301
            |..:   .:|                        |.::.||   ....:|.|:.|     .:..:
 Worm   134 WILKYLLSKC------------------------GEEQRGT---TAGCMWTVMIAWIGYNCVLVT 171

  Fly   302 LSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHI 366
            ::|.||...||.|.|||||:||..|:|..|...:...||:.|:||:..||..||..||||||:|.
 Worm   172 IAAILVIYVAPIAGGSGIPQIKCYLNGIAIPEVVRLKTLVSKAVGVACSVGGGLCAGKEGPMIHS 236

  Fly   367 ASCIGNIFSH-----------VFPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSY 420
            .:.:|...|.           :|.:: ||:.:||:.:||.|||||:.|||||||||||||||.:.
 Worm   237 GAAVGAGISQGKSYSLGIDFGLFREF-RNDREKRDFVSAGAAAGVAAAFGAPIGGVLFSLEEGAS 300

  Fly   421 YFPLKTLWRSFFCALIAAFVLRSLTPFGNEHS--------VLFFVEYNKPWIFFELIPFVFLGIM 477
            ::.....||.||.|:|::|.:..:..:.|..|        ..|.|..||.:..:|:..|:.:||:
 Worm   301 FWNQALTWRMFFSAMISSFTVNWILSWFNGRSGWLSWTGLANFGVFENKDYNIWEIPLFLLIGII 365

  Fly   478 GGVIGTFFIKANLWWCRYRK---FSKLGQYPVMEVLFVTLVTAII----------CYP---NP-F 525
            ||.:|..|...|.....:||   .||||:  :.|.|.|..|:..:          |.|   || .
 Worm   366 GGCLGALFNYLNTKLTEFRKKYVSSKLGR--LFECLLVAAVSGFLAFLTIFAIDDCQPIGANPTA 428

  Fly   526 TRMNMNELIFLLVSKCSPGDVT--------NPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLM 582
            |...:|::      .|..|:.:        ||....|.|..:..|||            .:..|:
 Worm   429 TSTQINQM------WCKKGEYSAVASLFFQNPEESVKSMFHSPINSF------------GVTTLV 475

  Fly   583 LTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNLIT 647
            :..|....||::|||:.||:|:|||::|.||..||:.||.||:.   :|::   ||       |.
 Worm   476 IFGIEYFLLTLWTFGISVPSGVFIPAILTGAAWGRLFGIFVERL---FPSV---TG-------ID 527

  Fly   648 PGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIA 712
            ||.||:.||||.||||.|||:||..|:.|.|..:.:.:|:|...|.:||||| :..:|:|||||.
 Worm   528 PGKYALAGAAAQLGGVVRMTISLTAIIMEATKDITFGLPIMLVLMVTKWVGD-MFNEGLYDAHID 591

  Fly   713 LNGYPFLD------SKEEFAHTTLAADVMQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVV 771
            |...|.|.      |:...|...:..||:..:|.|.::.|.:          :|:.|.|:|:|||
 Worm   592 LAEVPILGWNPPKMSRNILADRVMRKDVVALERRERVSRIVE----------ILRSTLHHGFPVV 646

  Fly   772 VS-RENQY--------LVGFVLRRDLNLAIGNAKRLIEGISSSSIVL-FTSSQ-------PIQNL 819
            .. .|:.|        |.|::||..|...:.|.....||.|:|::.. |...|       .:..|
 Worm   647 DRIEESPYESLPDYGRLKGYILRSQLFKLLENRIFEEEGASNSALPNDFYECQDDDDQMKSVAEL 711

  Fly   820 GPQPLKLKKILDMAPI------TVTDQTPMETVVDMFRKLGLRQTLVTH-NGRLLGVITKKDVLR 877
            |.........||:.|.      .|...|.:..:..:||.||||...|.: :..|.||||:|||.|
 Worm   712 GLTNFDESCFLDIEPYMHPHPHRVPLNTSLPFIFRLFRGLGLRYLFVVNDDNHLRGVITRKDVAR 776

  Fly   878 HVKQMDNED 886
            ..::..|.:
 Worm   777 FRERRRNRE 785

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_730105.3	ClC_3_like	215..719	CDD:239656	186/555 (34%)
		CBS_pair_voltage-gated_CLC_euk_bac	730..878	CDD:341367	48/171 (28%)
		CBS repeat	736..829	CDD:341367	26/109 (24%)
		CBS repeat	835..877	CDD:341367	17/48 (35%)
clh-6	NP_506022.1	ClC_6_like	70..598	CDD:239657	196/604 (32%)
		CBS_pair_voltage-gated_CLC_euk_bac	610..775	CDD:341367	48/174 (28%)
		CBS repeat	616..727	CDD:341367	30/120 (25%)
		CBS repeat	733..775	CDD:341367	16/41 (39%)