Protein Alignment ClC-c and clh-1

DIOPT Version :9

• Sequence 1: NP_001261922.1
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_001022373.1
• Gene: clh-1 / 174821
• WormBaseID: WBGene00000528
• Length: 906
• Species: Caenorhabditis elegans
• Alignment Length: 851
• Identity: 204/851 - (23%)
• Similarity: 346/851 - (40%)
• Gaps: 217/851 - (25%)

  Fly   151 SSDVQDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVG 215
            |||.:|......:|||::|   .....|......::.::.|:.:...::       .|.....:|
 Worm    78 SSDTEDQNDLDEEYEDYYT---DSKSTRRETTKEFLTRQFQNIVHFFVE-------DWFISAALG 132

  Fly   216 IAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRN 280
            ......:..:|:|..::...::.:......||                |.:.:..|  :|
 Worm   133 FITAIFSIFIDMGIEYLIHFRNFMLESLEQFN----------------NYAAFCGW--VF----- 174

  Fly   281 GTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSV 345
                ||...::          |:|.:...|...|.||||||:|.|:.||.::.||...||:.|.:
 Worm   175 ----YITGLVY----------LAALVCYGFGKQAVGSGIPEVKVIIHGFQLKNYLSGKTLIAKMI 225

  Fly   346 GLMLSVSAGLTLGKEGPMVHIASCIGNIFSHV-----FPKYGRNEAKKREILSAAAAAGVSVAFG 405
            ||.|::.:||.:|||||.|||.:.:.::.:.|     :..:..||.:..|:||...|.|::..|.
 Worm   226 GLTLTIGSGLPVGKEGPFVHIGAIVASLLNKVTAACQYNAFFSNEGRAMEMLSIGCAVGIACTFS 290

  Fly   406 APIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLR-SLTPFGNEHSVLFFVEY------NKPW 463
            ||:|.||:.:|..|.||.:|..|||||....:|.:.| ::..|..:|.......|      |:.:
 Worm   291 APMGAVLYGIESTSKYFAVKNYWRSFFATTCSAMLFRFAIAFFVPQHIAGTITAYYQTYFPNEVF 355

  Fly   464 IFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSK---------LGQYPVMEVLFVTLVTAII 519
            :..||..|:.||:|.|::|..|:    ::.|...|.|         .|:.|::.......:.|::
 Worm   356 VVEELPFFIGLGVMTGLLGALFV----YYHRRIAFFKRKNRIFQALFGKSPILFTACCAAIFAVL 416

  Fly   520 CYPNPF-----TRMNMNELIFLLVSKCSPGDVTNPL--CDYKRMNITSG--------NSFIEVTE 569
            .|||..     .:....|.:...:|.|:....||..  |....:...||        ||.:
 Worm   417 VYPNGLGSYVAGKYTFRETLVDFLSNCTLWKQTNGSEGCPPHMLEHWSGPEGDMMPINSLL---- 477

  Fly   570 PGPGVYSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIW 634
                    |:.|....|:.:.:|::     :|:|:|:|..::||..|||.|..:..       ||
 Worm   478 --------IYFLFYFIIVPICITLY-----IPSGIFVPCFVIGACGGRIFGEIISM-------IW 522

  Fly   635 FFTGECADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGD 699
            .:.........|.||||||||||:..|.||. ::|:.:|:.|.||.:..::|::.|.|.|..: .
 Worm   523 PYGLRGLGQPQIYPGLYAVVGAASFTGSVTH-SLSIALIVCETTGQLCALLPVLIALMISNAI-C 585

  Fly   700 ALGRQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPKRNETLNVITQDSMTVDDVENLLKETE 764
            |..:..|||:.|.:||||:|            ||:  |....:::.:..:.:.|.|:..:.:||.
 Worm   586 AFLQPSIYDSIIKINGYPYL------------ADL--PPSRMSVHQMKVERIMVKDIFYITRETT 636

  Fly   765 H-------------NGYPVVVSRENQYLVGFVLRRDL---------------------------- 788
            :             ..||.|....:..|:|.|.|:.|
 Worm   637 YRELREMLLESPTLRSYPFVTDSRSMTLLGSVARKYLLYLIQRKLGPEPELFGHRRRSRTASEIF 701

  Fly   789 --------------------NLAIGNAKRLIEGISSSSI------------------VLFTSS-- 813
                                :::.|||......||.:::                  :|:..:
 Worm   702 STINNLRKYSRRGSLAANGAHMSSGNALMTDRNISGNTLLPQSPLHEDQGDRSPLAPLLYAQTNQ 766

  Fly   814 -QPI-QNLGPQPLKLKKILDM-------APITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGV 869
             :|| .:|..:...|.|.|||       ||..:...|.:..|..:|..|.|....||..|||.||
 Worm   767 HEPIVHSLAKRAEILSKKLDMEEVAIDPAPFQLVRGTSLYKVHTLFSLLALNHAYVTEKGRLCGV 831

  Fly   870 ITKKDV 875
            :..|::
 Worm   832 VAVKEL 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	148/539 (27%)
		Voltage_CLC	298..699	CDD:279048	129/436 (30%)
		CBS	738..876	CDD:223591	41/228 (18%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	41/225 (18%)
clh-1	NP_001022373.1	ClC_1_like	124..607	CDD:239655	150/561 (27%)
		Voltage_CLC	182..585	CDD:279048	129/432 (30%)
		CBS_pair_EriC_assoc_euk_bac	<768..840	CDD:239964	23/70 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1170
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.860