Protein Alignment ClC-c and clh-2

DIOPT Version :10

• Sequence 1: NP_730105.3
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_001364585.1
• Gene: clh-2 / 174738
• WormBaseID: WBGene00000529
• Length: 878
• Species: Caenorhabditis elegans
• Alignment Length: 718
• Identity: 192/718 - (26%)
• Similarity: 320/718 - (44%)
• Gaps: 162/718 - (22%)

  Fly   286 IVAYIWYVLWA------LLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKS 344
            |.:|:.:..|.      .:||::...:|   :..|.||||||:|.|:.||.:..||...||:.|.
 Worm   125 ISSYLAFSQWVAHIVILTMFAAIFCQIV---SKQAVGSGIPEVKVIMHGFKMENYLTTRTLVAKM 186

  Fly   345 VGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHV-----FPKYGRNEAKKREILSAAAAAGVSVAF 404
            |||.|::..||.:|||||.||:.:.:..:.|.:     :..:..||.::.|:||:..|.|::..|
 Worm   187 VGLTLAMGGGLPIGKEGPFVHMGAIVATLLSKITSACQYSAFFSNEGREMEMLSSGCAVGIACTF 251

  Fly   405 GAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPF---GNEHSVLFFVEYNKP---W 463
            .||||.||:::|..|.||.:|..||.|..|..:|.|.|....|   ....::..|.:...|   :
 Worm   252 SAPIGAVLYAIESTSKYFAVKNYWRGFLAATCSAIVFRCANFFVTAEQSGTITAFYQTRFPTDCF 316

  Fly   464 IFFELIPFVFLGIMGGVIGTFFI----KANLWWCRYRKFSKLGQYPVME-VLFVTLVTAIICYPN 523
            :..||..|:.||.:.|::|:|||    :.:::..:.|.:..:.:...:. .:|:..|..::.:||
 Worm   317 LVEELPIFLLLGFISGLMGSFFIFIHRQISIFRSKNRVYKLIFRNNFLAFTVFMAFVVGVLTFPN 381

  Fly   524 PFTRMNMNELIFL-----LVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLML 583
            ...|.....|.|.     ..:.|:  .|:|   |.:|...|....:...:|....:::|   |:|
 Worm   382 GLGRYFAGRLTFRETMADFFNNCT--WVSN---DSRRCPDTILTHWTGGSEGDVSIFTS---LVL 438

  Fly   584 TFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECADSNLITP 648
            .:||...|......:.||||:|:||.::||..||::|   |.....:|......|    ...|.|
 Worm   439 YYILYFVLVAICISINVPAGVFVPSFIIGAAGGRLMG---ETMVVLFPEGMRGPG----GPPIHP 496

  Fly   649 GLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGR---QGIYDAH 710
            ||||||||||..|.||. |:|:.||:.||||.:..|:|::.|.:    :|:|:.:   ..||::.
 Worm   497 GLYAVVGAAAYTGAVTH-TLSVSVIICELTGQLSPILPVLIAML----MGNAVCKFLQPSIYESI 556

  Fly   711 IALNGYPFLDS---KEEFAHTT-----LAADVMQPKRNETLNVITQDSMTVDDVENLLKETEH-N 766
            |.:..||:|..   .....||.     :..||:         .||:| ||..:::.:|:...| .
 Worm   557 IRVKKYPYLPDLPPSRVSVHTVKVEQLMVTDVI---------YITKD-MTYREMKEILQLAPHLR 611

  Fly   767 GYPVVVSRENQYLVGFVLRRDLNLA--------------IGN----------------------- 794
            .:|:|...||:.|:|.|.:|.|.:.              ||.
 Worm   612 SFPIVTDHENKILLGSVAKRYLTMLLRRHVLVNQQDSRNIGRMTPSEIFNTIRRTSMRLSRRSPS 676

  Fly   795 -----------------------------AKRLIEG--ISSSSIVLFTSSQPIQNLGPQP----- 823
                                         ::|.|.|  :.|.|.:...::.|:|.:..:|
 Worm   677 RRSNSSQTRENSVPETARSDAPSDQVEFVSERTISGNTLLSISPLHCPNNIPLQAVFTRPSSADL 741

  Fly   824 --------LKLKKILDMAPITVTDQTPMETVV--------DMFRKLGLRQTLVTHNGRLLGVITK 872
                    :.|.:.:|:..|.: |..|.:.|:        .:|..|||....||..|:|:||:..
 Worm   742 SKTETNADILLNRNIDLDEIAI-DAAPFQLVLGSSLYKVHTLFSLLGLSHAYVTDCGKLVGVVGL 805

  Fly   873 KDV 875
            |::
 Worm   806 KEL 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_730105.3	ClC_3_like	215..719	CDD:239656	144/462 (31%)
		CBS_pair_voltage-gated_CLC_euk_bac	730..878	CDD:341367	45/236 (19%)
		CBS repeat	736..829	CDD:341367	27/174 (16%)
		CBS repeat	835..877	CDD:341367	15/49 (31%)
clh-2	NP_001364585.1	ClC_1_like	86..567	CDD:239655	145/464 (31%)
		CBS_pair_SF	580..809	CDD:449531	45/240 (19%)
		CBS repeat	585..761	CDD:341358	30/185 (16%)
		CBS repeat	768..809	CDD:341358	12/41 (29%)