Protein Alignment ClC-c and clh-5

DIOPT Version :9

• Sequence 1: NP_001261922.1
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: NP_495940.1
• Gene: clh-5 / 174449
• WormBaseID: WBGene00000532
• Length: 797
• Species: Caenorhabditis elegans
• Alignment Length: 853
• Identity: 426/853 - (49%)
• Similarity: 566/853 - (66%)
• Gaps: 90/853 - (10%)

  Fly    61 SLTAAGTDDEDMIDITPRSSPGDV-IGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNHHN 124
            |.|...|||   :::.|..:...: :....||||||.             ||...|
 Worm     7 SSTLGSTDD---VELEPSGTSATIHLDMTAGGGSSSS-------------DFNPFG--------- 46

  Fly   125 QRTMHQHVPTHSAFGDPMDGALSFYGSSDVQDDI--PGIGQYEDFHTIDWQRDIARDRMRHRYIV 187
                        |..|     :.|....|:.|.:  |...:|.||||||||||:||||:||:.|.
 Worm    47 ------------AIDD-----VRFKTDDDLPDVMAPPFFSKYGDFHTIDWQRDLARDRLRHKMIS 94

  Fly   188 KKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCC 252
            ||:.|....|::...|||:||:|||.||:|||..||::||||.||||||.|:|...||.:.|.||
 Worm    95 KKKVDFPLGLLQSGWDAGAGWICVLFVGLAAGATAGIIDIGARWMSDLKTGVCADRFWLDHEHCC 159

  Fly   253 YPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYI-VAYIWYVLWALLFASLSASLVRMFAPYACG 316
            :.:..:.:::.:|..|..||.:.....:.:..:: :.:|:|:.||:..::|:...|::|||||||
 Worm   160 WSSNDTFYKDDDCKAWTKWPWMLNYYNSSSFLFLFLEWIFYIGWAVAMSTLAVLFVKIFAPYACG 224

  Fly   317 SGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKY 381
            |||||||.|||||:|||||||||.:||||||:||.::||:|||||||||:|.|||||||::||||
 Worm   225 SGIPEIKCILSGFVIRGYLGKWTFIIKSVGLILSSASGLSLGKEGPMVHLACCIGNIFSYLFPKY 289

  Fly   382 GRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTP 446
            |.|||||||||||:||||||||||||||||||||||.||||||||:||||||||:|..:||.:.|
 Worm   290 GLNEAKKREILSASAAAGVSVAFGAPIGGVLFSLEEASYYFPLKTMWRSFFCALVAGIILRFVNP 354

  Fly   447 FGNEHSVLFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSK-LGQYPVMEVL 510
            ||:..:.||.|:|...|.|.||:||..||:.||:||:.||.||:.|.|:||.|| ||..|:.||:
 Worm   355 FGSNQTSLFHVDYMMKWTFIELVPFAILGLFGGIIGSLFIFANIRWSRFRKNSKMLGGNPIYEVM 419

  Fly   511 FVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDY-KRMNITSGNSFIEVTEPGPGV 574
            .:|||||.|.|.|||||.:...:|..|..:|......:.|||. |.::|..|
 Worm   420 LITLVTAAISYFNPFTRKSAQSMIQQLFDRCEDQIDEDSLCDQNKALSIAFG------------- 471

  Fly   575 YSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQF---AYSYP-NIWF 635
             ..:|.|    |.|..:||||||:|||.|||:||:.:|||.|||:||.|:|.   ..:.| :..:
 Worm   472 -QLLWAL----IFKFVITIFTFGIKVPCGLFVPSIGMGAIAGRILGITVDQIFRAVQATPGHSDY 531

  Fly   636 FTGECADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDA 700
            ||.:.. .:.:.|||||:||||||||||||||||||||||||||.:.:|||.|.|.|.|||:||.
 Worm   532 FTCQIG-KDCVMPGLYAMVGAAAVLGGVTRMTVSLVVIMFELTGSLEFIVPTMVATMFSKWIGDG 595

  Fly   701 LGRQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPK-----------------RNETLNVITQ 748
            :.:.|||:|||.||||||||||.|:.::|:|:.||:|.                 :|| |:|||:
 Worm   596 ISKMGIYEAHIELNGYPFLDSKGEYPYSTVASQVMRPSIHRQVADEMSMSDLRELKNE-LSVITE 659

  Fly   749 DSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLFTSS 813
            ..||:.|:|:||::|:.||:|||||:.:.:||||:.|||:.||:..|::....:.::||..|:..
 Worm   660 SGMTLGDLESLLRQTDFNGFPVVVSQNSMHLVGFITRRDILLALHTARKTQPYVVTNSIAYFSDG 724

  Fly   814 QP-IQNLGPQPLKLKKILDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLR 877
            .| ....||.||:|:|||||||:|||||||||||:|||||||||..|||.||::||:|||||:|:
 Worm   725 VPDAMPGGPAPLRLRKILDMAPMTVTDQTPMETVIDMFRKLGLRHVLVTKNGKVLGIITKKDILQ 789

  Fly   878 HVKQMDNE 885
            .::..:::
 Worm   790 FMRNKNSQ 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	284/510 (56%)
		Voltage_CLC	298..699	CDD:279048	240/406 (59%)
		CBS	738..876	CDD:223591	78/155 (50%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	78/137 (57%)
clh-5	NP_495940.1	ClC_3_like	122..614	CDD:239656	284/510 (56%)
		Voltage_CLC	206..594	CDD:279048	240/406 (59%)
		CBS	650..788	CDD:223591	78/138 (57%)
		CBS_pair_EriC_assoc_euk_bac	653..790	CDD:239964	78/137 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162459
Domainoid	1	1.000	461	1.000	Domainoid score	I240
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20435
Inparanoid	1	1.050	800	1.000	Inparanoid score	I251
Isobase	1	0.950	-	0	Normalized mean entropy	S1170
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D116173at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		oto20375
orthoMCL	1	0.900	-	-		OOG6_100336
Panther	1	1.100	-	-	LDO	PTHR45711
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1878
SonicParanoid	1	1.000	-	-		X829
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750