DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and Clcnka

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_001139779.1	Gene:	Clcnka / 12733	MGIID:	1329026	Length:	687	Species:	Mus musculus

Alignment Length:	676	Identity:	193/676 - (28%)
Similarity:	305/676 - (45%)	Gaps:	151/676 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 GTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSV 345
            |.| :::.|:.:.::.:...|.|:...:...|::.|||:||:||:|||.::..||.......|.|
Mouse    86 GDG-HLLRYLSWTVYPVALLSFSSGFSQSITPFSGGSGLPELKTMLSGVVLENYLDIKNFGAKVV 149

  Fly   346 GLMLSVSAGLT--LGKEGPMVHIASCIGNIFSHVFPK-YGRNEAKKREI--LSAAAAAGVSVAFG 405
            ||..:::.|.|  |||.||.||::..|......|..| .|..|:|.:|:  ||||||.||:..|.
Mouse   150 GLSCTLATGSTIFLGKVGPFVHLSVMISAYLGRVRAKAVGDTESKAKEVEMLSAAAAVGVATVFA 214

  Fly   406 APIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSVL-------FFVE--YNK 461
            ||..|||||:|.:|.:|.:...||.||.|...||:.|.|..|.:|...:       |.|:  ::.
Mouse   215 APFSGVLFSIEVMSSHFSVWNYWRGFFAATCGAFMFRLLAVFNSEQETITSIYKTRFRVDVPFDL 279

  Fly   462 PWIFFELIPFVFLGIMGGVIGTFFIKANLWWCR--YRKFSKLGQY---------PVMEVLFVTLV 515
            |.|||    ||.||.:.|::...::     :|:  :.:|.|..:|         |....| |.||
Mouse   280 PEIFF----FVALGFICGILSCVYL-----FCQRNFLRFIKTNRYTSKLLATSKPSYAAL-VALV 334

  Fly   516 TAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVT---------EPG 571
            .|.:.||....|        .:.|:.|..:..:.|.|        .||:..:|         ||.
Mouse   335 LASVTYPPGVGR--------FMASRLSMAEHLHSLFD--------NNSWALMTRNASPPWPSEPD 383

  Fly   572 PGVYSSIW-----------------LLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIV 619
            |   .::|                 |:|..::|.||.||     .:|||.|:|..::||.:||::
Mouse   384 P---QNLWFEWYHPRFTIFGTLAFFLIMKFWMLILATTI-----PMPAGYFMPIFIIGAAIGRLL 440

  Fly   620 GIGVEQFAYSYPNIWFFTGECADSNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYI 684
            |   |..:.::|......||...   |.||.||:.||||..|.||. |:|..::.|||||.:.:.
Mouse   441 G---EALSVAFPEGIVAGGEVYP---IMPGGYALAGAAAFSGAVTH-TISTALLAFELTGQIVHA 498

  Fly   685 VPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLD------------SKEEFAH---TTLAADV 734
            :|::.|.:|:..:...| :...||..|.....|:|.            :.|.|.:   ||||.|
Mouse   499 LPVLMAVLAANVISQNL-QPSFYDGTIMAKKLPYLPWIRGRQIGSYPVTVEHFMNSNLTTLAKD- 561

  Fly   735 MQPKRNETLNVITQDSMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIGNAKRLI 799
                            |.:::|..::..|:.:.||:|.:||:|.|||.|.|..|..|:
Mouse   562 ----------------MPLEEVVKVVTSTDVSQYPLVETRESQTLVGIVERTHLVQAL------- 603

  Fly   800 EGISSSSIVLFTSSQPIQNLGPQPLKLKKIL----DMAPIT--VTDQTPMETVVDMFRKLGLRQT 858
                        .:||......|...|:.||    ...|:|  ::.:|.:.....:|..|.|:..
Mouse   604 ------------QTQPASWAPGQERFLQDILAGGCPTQPVTLQLSPETSLYQAHRLFELLTLQAL 656

  Fly   859 LVTHNGRLLGVITKKDVLRHVKQMDN 884
            .||..||.:|.::..::.:.:..:.|
Mouse   657 FVTSRGRAVGSVSWVELKKAISTLIN 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	151/488 (31%)
		Voltage_CLC	298..699	CDD:279048	143/451 (32%)
		CBS	738..876	CDD:223591	33/143 (23%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	33/142 (23%)
Clcnka	NP_001139779.1	ClC_1_like	49..533	CDD:239655	151/489 (31%)
		Voltage_CLC	106..514	CDD:279048	142/448 (32%)
		CBS_pair_EriC_assoc_euk_bac	555..676	CDD:239964	38/156 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845465
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D271925at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.760