Protein Alignment ClC-c and ClC-a

DIOPT Version :10

• Sequence 1: NP_730105.3
• Gene: ClC-c / 39759
• FlyBaseID: FBgn0036566
• Length: 893
• Species: Drosophila melanogaster
• Sequence 2: XP_061498046.1
• Gene: ClC-a / 1273077
• VectorBaseID: AGAMI1_005630
• Length: 1150
• Species: Anopheles gambiae
• Alignment Length: 996
• Identity: 237/996 - (23%)
• Similarity: 384/996 - (38%)
• Gaps: 338/996 - (33%)

  Fly   140 DPMDGALSFYGSSDVQDDIPGIGQYEDFHTI---------DWQRDIAR------------DRMRH 183
            ||.|       ..:::..|..| :.|:|:.:         ::.:|.||            |:.|:
Mosquito   144 DPAD-------KDEIRRSIVDI-EIEEFYYMYGRYTKDLGEYAKDEARRLRLLERRRKKDDKARN 200

  Fly   184 RYIVKKRQDS-------LWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICP 241
            :.::..|.:.       ||......:  |..|:.:.|:||....::.::|.|.|.
Mosquito   201 KELLDVRDNKFFKAASWLWRNTFARL--GEDWVFLALLGIIMALLSYVMDKGISM---------- 253

  Fly   242 PAFWFNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASL 306
                                   |:..:.|     |.|:.|...::.|:.:|...:.....||..
Mosquito   254 -----------------------CTNSRVW-----LYRDLTNHPVLQYLAWVSLPVCLILFSAGF 290

  Fly   307 VRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIG 371
            |.:.||.:.||||||:||||.|..::.||...||:.|.:||..::.:|:.||||||.|||||.:.
Mosquito   291 VHLVAPQSIGSGIPEMKTILRGVALKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVHIASIVS 355

  Fly   372 NIFSHV---FPKYGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFC 433
            .:.|.:   |.....||::..|:|:||.|.||...|.|||||||||:|..:.||.::..||.||.
Mosquito   356 QLLSKIITSFQSIYENESRNTEMLAAACAVGVGACFAAPIGGVLFSIEVTTTYFAVRNYWRGFFA 420

  Fly   434 ALIAAFVLRSLTPF---GNEHSVLFFVEYNKPWIF--FELIPFVFLGIMGGVIGTFFI----KAN 489
            |:..|.|.|.|..:   .:..:.:|...:...:.|  .||..|..:|::.|:.|..::    |..
Mosquito   421 AVCGATVFRLLAVWFQKADTVTAMFSTNFTSDFPFDPQELFVFALIGLVCGLGGALYVWVHRKYV 485

  Fly   490 LWWCRYRKFSKLGQ-----YPVMEVLFVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNP 549
            |:....:|.:|..|     ||.:    |.|:.|.:.:|..|.:....||        |..|..:.
Mosquito   486 LFMRSNKKMNKFLQKNRFLYPGI----VALIVATLSFPLGFGKYIAGEL--------STHDQVHQ 538

  Fly   550 LCDYKRMNITSGNSFIEVT-------EPGPGVYSS--IWLLMLTFILKLALTIFTFGMKVPAGLF 605
            |  :.....|.....:|..       .|...|:::  |:||...|:..:|.||     .||:|:|
Mosquito   539 L--FSNFTWTKHELTVEQAAVVSNWRTPETNVFANLIIYLLYTFFMSIIASTI-----PVPSGMF 596

  Fly   606 IPSLLLGAIMGRIVGIGVEQFAYSYPNIWF-----FTGECADSNLITPGLYAVVGAAAVLGGVTR 665
            ||...:||..|||:|..:        ::||     :.|..|.   |.||.|:||||||..|.||.
Mosquito   597 IPVFKIGAAFGRIIGEAM--------HLWFPHGVRYGGMLAP---IIPGGYSVVGAAAFSGAVTH 650

  Fly   666 MTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEFAHTTL 730
             |||:.||:||:||.:.:|||:|.||:.|..|. ||.:..:||:.|.:...|:|..
Mosquito   651 -TVSVGVIVFEMTGQITHIVPVMIAALISNAVA-ALLQPSMYDSIILIKKLPYLPD--------- 704

  Fly   731 AADVMQPKRNETLNVITQDSMTVD-----------DVENLLKETEH-NGYPVVVSRENQYLVGFV 783
                :.|..:...|:..:|.|..|           .::.:||..:. ...|:|.|.:|:.|:|.|
Mosquito   705 ----LLPSGSGMYNIYVEDFMVRDVRYIWKGISYQQLKEILKANKSLRSLPIVDSPDNRTLLGSV 765

  Fly   784 LRRDL----NLAIGNAKRL---------------------------------------------- 798
            .|.:|    :..||..|||
Mosquito   766 QRYELIKMIDKHIGREKRLEVAAKLMKEAEEKAREEQERQKREAAEAAKARRPSRFEVVPAPDIL 830

  Fly   799 ----------------------------------------------IEGIS-------------- 803
                                                          ::|.|
Mosquito   831 KLRERANNEMLPPQARRESNASLTSGPMFGATQPKKSILKKTNSFTLKGFSPLSPHSPVHTPYTT 895

  Fly   804 ---------SSSIVLFTSSQPIQNLGPQP---------------------------LKLKKILDM 832
                     |:..::|..|..:|::.|.|                           |..::::||
Mosquito   896 ITGTESRIRSAFDIIFRKSATLQDVTPDPEIGSIGTPSIVGSEVAPLTPGISKKVQLPRERVIDM 960

  Fly   833 --------------------------APITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVIT 871
                                      ||..:.::|.:..|..:|..:|:....||:.|||:||:.
Mosquito   961 SPEDQKAWEMEEMAKPIDVGNLHIDPAPFQLVERTSILKVHSLFSMVGINHAYVTNVGRLVGVVA 1025

  Fly   872 KKDVLRHVKQMDNE--DPNTV 890
            .|::...::.::|.  .|.||
Mosquito  1026 LKELRTAIESVNNGTLTPETV 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_730105.3	ClC_3_like	215..719	CDD:239656	168/534 (31%)
		CBS_pair_voltage-gated_CLC_euk_bac	730..878	CDD:341367	46/331 (14%)
		CBS repeat	736..829	CDD:341367	30/250 (12%)
		CBS repeat	835..877	CDD:341367	12/41 (29%)
ClC-a	XP_061498046.1	None