DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and Clcn5

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_011245744.1	Gene:	Clcn5 / 12728	MGIID:	99486	Length:	851	Species:	Mus musculus

Alignment Length:	833	Identity:	482/833 - (57%)
Similarity:	608/833 - (72%)	Gaps:	43/833 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AGTDDEDMIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNHHNQRTMH 129
            :.:.|||::||     ||..:...         .|:.....|.|.: |:...||||...:.|.|
Mouse    58 SSSSDEDLMDI-----PGTAMDFS---------MRDDVPPLDREIE-GNKSYNGGGIGSSNRVM- 106

  Fly   130 QHVPTHSAFGDPMDGALSFYGSSDVQDDIPGIGQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSL 194
                                  ..:::.|||:|.|:||:||||.|:.:|||.|||.|..|.::|.
Mouse   107 ----------------------DFLEEPIPGVGTYDDFNTIDWVREKSRDRDRHREITNKSKEST 149

  Fly   195 WDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSV 259
            |.||....||.||||.:||:|:.:|.:||::||.|.||:|||.|||...||||.|.||:.::...
Mouse   150 WALIHSVSDAFSGWLLMLLIGLLSGSLAGLIDISAHWMTDLKEGICTGGFWFNHEHCCWNSEHVT 214

  Fly   260 FE-EGNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIK 323
            || ...|..|.:|.::......|...|||.|..|||||||||.|:.|||:.||||||||||||||
Mouse   215 FEHRDKCPEWNSWAQLIINTDQGAFAYIVNYFMYVLWALLFAFLAVSLVKAFAPYACGSGIPEIK 279

  Fly   324 TILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPKYGRNEAKK 388
            |||||||||||||||||:||::.|:|:||:||:||||||:||:|.|.|||..|.|.||.:||||:
Mouse   280 TILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLGKEGPLVHVACCCGNILCHCFNKYRKNEAKR 344

  Fly   389 REILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEHSV 453
            ||:|||||||||||||||||||||||||||||||||||||||||.||:|||.|||:.||||...|
Mouse   345 REVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLV 409

  Fly   454 LFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVLFVTLVTAI 518
            ||:||::.||..|||:||:.|||.||:.|..||:.|:.|||.||.::||:|||:|||.||.:|||
Mouse   410 LFYVEFHTPWHLFELVPFIVLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVVEVLIVTAITAI 474

  Fly   519 ICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIEVTEPGPGVYSSIWLLML 583
            :.:||.:|||:.:|||..|.:.|...| ::.||||:....||....:.....|.|:||::|.|.|
Mouse   475 LAFPNEYTRMSTSELISELFNDCGLLD-SSKLCDYENHFNTSKGGELPDRPAGVGIYSAMWQLAL 538

  Fly   584 TFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGECAD-SNLIT 647
            |.|||:.:||||||||:|:||||||:.:|||.||::|:|:||.||.:.:...|...|:. ::.||
Mouse   539 TLILKIVITIFTFGMKIPSGLFIPSMAVGAIAGRLLGVGMEQLAYYHHDWGIFNSWCSQGADCIT 603

  Fly   648 PGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGRQGIYDAHIA 712
            |||||:|||||.|||||||||||||||||||||:.||||||||||.||||.|||||:|||||||.
Mouse   604 PGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIR 668

  Fly   713 LNGYPFLDSKEEFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDVENLLKETEHNGYPVVVSREN 776
            |||||||::||||||.|||.|||:|:||: .|.|:|||||||:|||.::.||.::|:|||||||:
Mouse   669 LNGYPFLEAKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRES 733

  Fly   777 QYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLFTS-SQPIQNLGPQPLKLKKILDMAPITVTDQ 840
            |.||||||||||.::|.||::..:|:.|:||:.||. |.|:....|..|||:.|||::|.||||.
Mouse   734 QRLVGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPMPPYTPPTLKLRNILDLSPFTVTDL 798

  Fly   841 TPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQMDNEDPNTVLFN 893
            ||||.|||:||||||||.||||||||||:|||||||:|:.||.|:||:::|||
Mouse   799 TPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMANQDPDSILFN 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	319/505 (63%)
		Voltage_CLC	298..699	CDD:279048	264/401 (66%)
		CBS	738..876	CDD:223591	88/139 (63%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	88/138 (64%)
Clcn5	XP_011245744.1	ClC_3_like	177..675	CDD:239656	317/498 (64%)
		CBS_pair_voltage-gated_CLC_euk_bac	686..836	CDD:341367	96/149 (64%)
		CBS repeat	692..787	CDD:341367	51/94 (54%)
		CBS repeat	793..835	CDD:341367	35/41 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845467
Domainoid	1	1.000	544	1.000	Domainoid score	I260
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	960	1.000	Inparanoid score	I330
Isobase	1	0.950	-	0	Normalized mean entropy	S1170
OMA	1	1.010	-	-		QHG55339
OrthoDB	1	1.010	-	-		D116173at33208
OrthoFinder	1	1.000	-	-		FOG0000220
OrthoInspector	1	1.000	-	-		otm43308
orthoMCL	1	0.900	-	-		OOG6_100336
Panther	1	1.100	-	-	LDO	PTHR45711
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X829
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.720