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Protein Alignment ClC-c and Clcn3

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_776299.1	Gene:	Clcn3 / 12725	MGIID:	103555	Length:	866	Species:	Mus musculus

Alignment Length:	834	Identity:	482/834 - (57%)
Similarity:	610/834 - (73%)	Gaps:	56/834 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SLTAAGTDDEDMIDITPRSSPGDVIGGGGGGGSSSGYHRETATESDTERDFGHSGGNGGGNHHNQ 125
            |:|:| :.||:::|               |.|:...:.   .:|.|...|    |....|.|:.
Mouse    18 SITSA-SSDEELLD---------------GAGAIMDFQ---TSEDDNLLD----GDTAAGTHYT- 58

  Fly   126 RTMHQHVPTHSAFGDPMDGALSFYGSS---DVQDD-IPGIGQYEDFHTIDWQRDIARDRMRHRYI 186
                            |....|...|:   |:.|: |||:|.|:|||||||.|:..:||.|||.|
Mouse    59 ----------------MTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRI 107

  Fly   187 VKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFNREQC 251
            ..|:::|.|::.|...||.||||.|.|.|:|:|.:||::||.|.||:|||.|||..|.|:|.|||
Mouse   108 NSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQC 172

  Fly   252 CYPAKQSVFEE-GNCSTWKTWPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPYAC 315
            |:.:.::.||| ..|..||||.|:......|.|.||:.||.|:.|||.||.|:.|||::||||||
Mouse   173 CWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYAC 237

  Fly   316 GSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFSHVFPK 380
            |||||||||||||||||||||||||:||::.|:|:|::||:||||||:||:|.|.|||||::|||
Mouse   238 GSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPK 302

  Fly   381 YGRNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLT 445
            |..|||||||:||||:||||||||||||||||||||||||||||||||||||.||:|||||||:.
Mouse   303 YSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSIN 367

  Fly   446 PFGNEHSVLFFVEYNKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCRYRKFSKLGQYPVMEVL 510
            ||||...|||:|||:.||..|||.||:.||:.||:.|.|||:||:.|||.||.:|.|:|||:||:
Mouse   368 PFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVI 432

  Fly   511 FVTLVTAIICYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKR-MNITSGNSFIEVTEPGPGV 574
            .|..:||:|.:|||:||:|.:|||..|.:.|.|.: ::.||||:. ||.:.....|.....|.||
Mouse   433 IVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLE-SSSLCDYRNDMNASKIVDDIPDRPAGVGV 496

  Fly   575 YSSIWLLMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGE 639
            ||:||.|.|..|.|:.:|:||||:|||:||||||:.:|||.||||||.|||.|| |.:.||...|
Mouse   497 YSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAY-YHHDWFIFKE 560

  Fly   640 CAD--SNLITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALG 702
            ..:  ::.|||||||:|||||.||||||||||||||:||||||:.||||||||.|.|||||||.|
Mouse   561 WCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFG 625

  Fly   703 RQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPKRNE-TLNVITQDSMTVDDVENLLKETEHN 766
            |:|||:|||.||||||||:||||.|||||||||:|:|:: .|.|:|||:|||||:||::.||.:|
Mouse   626 REGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYN 690

  Fly   767 GYPVVVSRENQYLVGFVLRRDLNLAIGNAKRLIEGISSSSIVLF---TSSQPIQNLGPQPLKLKK 828
            |:||::|:|:|.||||.|||||.:||.:|::..|||..||.|.|   |.|.|.::  |:||||:.
Mouse   691 GFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAES--PRPLKLRS 753

  Fly   829 ILDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVKQM 882
            ||||:|.||||.||||.|||:||||||||.||||||.:||:||||::|.|::|:
Mouse   754 ILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKNILEHLEQL 807

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.