DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and Clcn2

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	XP_017172351.1	Gene:	Clcn2 / 12724	MGIID:	105061	Length:	915	Species:	Mus musculus

Alignment Length:	843	Identity:	214/843 - (25%)
Similarity:	346/843 - (41%)	Gaps:	218/843 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 HRYIVKKRQDSLWDLIKGSIDAGSGWLCVLLVGIAAGCVAGMVDIGASWMSDLKHGICPPAFWFN 247
            |:::|.:              .|..|:.::|:|:....|        ||..|....:|
Mouse    88 HKFLVSR--------------VGEDWIFLVLLGLLMALV--------SWAMDYAIAVC------- 123

  Fly   248 REQCCYPAKQSVFEEGNCSTWKT--WPEIFGLDRNGTGPYIVAYIWYVLWALLFASLSASLVRMF 310
                         .:|....|:.  |.. .||:.|    .::.|:.:|.:.::..:.||...::.
Mouse   124 -------------LQGEGKGWRAQQWMS-RGLNTN----ILLQYLAWVTYPVVLITFSAGFTQIL 170

  Fly   311 APYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGPMVHIASCIGNIFS 375
            ||.|.||||||:||||.|.:::.||...|.:.|.:||..::.:|:.||||||.|||||....:.|
Mouse   171 APQAVGSGIPEMKTILRGVVLKEYLTLKTFVAKVIGLTCALGSGMPLGKEGPFVHIASMCAALLS 235

  Fly   376 HVFPKYG---RNEAKKREILSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFCALIA 437
            .....:|   .:|::..|:|:||.|.||...|.|||||||||:|..|.:|.::..||.||.|..:
Mouse   236 KFLSLFGGIYEHESRNTEMLAAACAVGVGCCFAAPIGGVLFSIEVTSTFFAVRNYWRGFFAATFS 300

  Fly   438 AFVLRSLTPFGNEH---SVLFFVEY--NKPWIFFELIPFVFLGIMGGVIGTFFIKANLWWCR-YR 496
            ||:.|.|..:..:.   :.||...:  :.|:...||..|..:||..|..|..|:..|....: .|
Mouse   301 AFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQELPAFAVIGIASGFGGALFVYLNRKIVQVMR 365

  Fly   497 KFSKLGQYPVME-VLFVTLVTAII---CYPNPFTRMNMNELIFLLVSKCSPGDVTNPLCD---YK 554
            |...:.::.:.: :||..|||.:|   .:|..|.:....:|        |..:....|.|   :.
Mouse   366 KQKTINRFLMRKRLLFPALVTLLISTLTFPPGFGQFMAGQL--------SQKETLVTLFDNRTWV 422

  Fly   555 RMNITSGNSFIEVTEPGPGVYSSIWLLMLTFIL-KLALTIFTFGMKVPAGLFIPSLLLGAIMGRI 618
            |..:.........::......::::|.::.||| |..::.....:.||.|.|:|..::||..||:
Mouse   423 RQGLVEDLELPSTSQAWSPPRANVFLTLVIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRL 487

  Fly   619 VGIGVEQFAYSYPNIWFFTGECADSNL--ITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGV 681
            ||   |..|     .||..|...||:.  |.||.||||||||:.|.||. |||..||:|||||.:
Mouse   488 VG---ESMA-----AWFPDGIHTDSSTYRIVPGGYAVVGAAALAGAVTH-TVSTAVIVFELTGQI 543

  Fly   682 RYIVPLMAAAMASKWVGDALGRQGIYDAHIALNGYPFLDSKEEFAHTTLAADVMQPKRNETLNVI 746
            .:|:|:|.|.:.:..|..:| :..:||:.|.:...|:|.......|        |..|....:::
Mouse   544 AHILPVMIAVILANAVAQSL-QPSLYDSIIRIKKLPYLPELGWGRH--------QQYRVRVEDIM 599

  Fly   747 TQD------SMTVDDVENLLKETEHNGYPVVVSRENQYLVGFVLRRDLNLAIG------------ 793
            .:|      |.|..|:...|..|:.....:|.|.|:..|:|.:.|..:...:|
Mouse   600 VRDVPHVALSCTFRDLRLALHRTKGRMLALVESPESMILLGSIERSQVVALLGAQLSPARRRQHM 664

  Fly   794 -------------------------------------------------------NAKRLIEG-- 801
                                                                   |:..|.||
Mouse   665 QKLRKAQLSPPSDQESPPSSETSIRFQVNTEDSGFSGAHGQTHKPLKPALKRGPSNSTSLQEGTT 729

  Fly   802 --ISSSSIV---LFTSSQPIQNLGP-------QPLKLKKI------------------------- 829
              :.|:.|.   ||..|.|::....       ...|||::
Mouse   730 GNMESAGIALRSLFCGSPPLEATSELEKSESCDKRKLKRVRISLASDSDPEAEMSPEEILEWEEQ 794

  Fly   830 ------------LDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVK 880
                        :|.||..:.::|.:.....:|..||:....||..|||:|::|.|::.:.::
Mouse   795 QLDEPVNFSDCKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAIE 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	164/524 (31%)
		Voltage_CLC	298..699	CDD:279048	145/419 (35%)
		CBS	738..876	CDD:223591	42/261 (16%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	41/260 (16%)
Clcn2	XP_017172351.1	ClC_1_like	98..582	CDD:239655	167/534 (31%)
		CBS_pair_voltage-gated_CLC_euk_bac	594..855	CDD:341367	41/260 (16%)
		CBS repeat	600..806	CDD:341367	26/205 (13%)
		CBS repeat	812..854	CDD:341367	12/41 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845466
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740