DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ClC-c and Clcn1

DIOPT Version :9

Sequence 1:	NP_001261922.1	Gene:	ClC-c / 39759	FlyBaseID:	FBgn0036566	Length:	893	Species:	Drosophila melanogaster
Sequence 2:	NP_038519.1	Gene:	Clcn1 / 12723	MGIID:	88417	Length:	994	Species:	Mus musculus

Alignment Length:	966	Identity:	239/966 - (24%)
Similarity:	368/966 - (38%)	Gaps:	317/966 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 FGHSGGNGGGNHHNQRTMHQHVPTHSA-----FG--------DPMDGAL-SFYGSSDVQDDIPGI 161
            :|....|||..|..::.|.   |.|:|     :|        ...||.: ...|||...|.:.
Mouse    33 YGLPSENGGLQHRPRKDMG---PRHNAHPTQIYGHQKEQYSYKAQDGGMPKKMGSSSTMDSLD-- 92

  Fly   162 GQYEDFHTIDWQRDIARDRMRHRYIVKKRQDSLWDLIKGSI---DAGSGWLCVLLVGIAAGCVAG 223
               ||.::                   |.||.:..|  |.:   ..|..|:.::|:|:....|
Mouse    93 ---EDHYS-------------------KCQDCVHRL--GRVLRRKLGEDWIFLVLLGLLMALV-- 131

  Fly   224 MVDIGASWMSDLKHGICPPAFWFNREQCCYPAKQSVFEEGNCSTWKTWPEIFGLDRNGTGPYI-V 287
                  ||..|                  |.:.:|:    ....| |:.::        .|.: :
Mouse   132 ------SWCMD------------------YVSAKSL----QAYKW-TYAQM--------KPSLPL 159

  Fly   288 AYIWYVLWALLFASLSASLVRMFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKSVGLMLSVS 352
            .|:.:|.:.|:....||...::.:|.|.||||||:||||.|.:::.||.....:.|.|.|...:.
Mouse   160 QYLAWVTFPLILILFSALFCQLISPQAVGSGIPEMKTILRGVVLKEYLTLKAFVAKVVALTAGLG 224

  Fly   353 AGLTLGKEGPMVHIAS-CIG------NIFSHVF--PKYGRNEAKKREILSAAAAAGVSVAFGAPI 408
            :|:.:|||||.||||| |..      ::||.|:  |.|      ..:||:...|.||...||.|:
Mouse   225 SGIPVGKEGPFVHIASICAAVLSKFMSMFSGVYEQPYY------YTDILTVGCAVGVGCCFGTPL 283

  Fly   409 GGVLFSLEEVSYYFPLKTLWRSFFCALIAAFVLRSLTPFGNEH---SVLFFVEYNK--PWIFFEL 468
            ||||||:|..|.||.::..||.||.|..:|||.|.|..:..:.   :.||...:..  |:...||
Mouse   284 GGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKEL 348

  Fly   469 IPFVFLGIMGGVIGTFFIKANLWWCRY---------RKFSKLGQYPVMEVL----FVTLVTAIIC 520
            ..|..:||..|.:|..|:        |         ||...|.|:.....|    .||.|.|.:.
Mouse   349 PAFAVIGICCGFLGAVFV--------YLHRQVMLGVRKHKCLSQFLAKHRLLYPGIVTFVIASLT 405

  Fly   521 YPNPFTRMNMNELIFLLVSKCSPGDVTNPLCDYKRMNITSGNSFIE-VTEPGPGVYSSIWL---- 580
            :|....:....||:        |.:..:.|.|        .|:::: :.:|.....|::||
Mouse   406 FPPGMGQFMAGELM--------PREAISTLFD--------NNTWVKHIGDPQSLGQSAVWLHPQV 454

  Fly   581 -----LMLTFILKLALTIFTFGMKVPAGLFIPSLLLGAIMGRIVGIGVEQFAYSYPNIWFFTGEC 640
                 ::|.|::|..::|....|.:|.|.|:|..:|||..||:||   |..|..:|.     |..
Mouse   455 NVIIIILLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVG---EIMAMLFPE-----GIL 511

  Fly   641 ADSNL--ITPGLYAVVGAAAVLGGVTRMTVSLVVIMFELTGGVRYIVPLMAAAMASKWVGDALGR 703
            .|..:  |.||.|||:||||:.|.|:. |||..||.|||||.:.:|:|:|.|.:.:..|..:| :
Mouse   512 FDDIIYKILPGGYAVIGAAALTGAVSH-TVSTAVICFELTGQIAHILPMMVAVILANMVAQSL-Q 574

  Fly   704 QGIYDAHIALNGYPFL-----DSKEEFAHTTLAADVMQPKRNETLNVITQD------SMTVDDVE 757
            ..:||:.|.:...|:|     :...:|  |....|:|           .:|      |.|..::.
Mouse   575 PSLYDSIIQVKKLPYLPDLGWNQLSKF--TIFVEDIM-----------VRDVKFVSASCTYGELR 626

  Fly   758 NLLKETEHNGYPVVVSRENQYLVGFVLR--------------RDLNLAIGNAKRLIE-------- 800
            |||:.|.....|:|.|:::..|:|.|.|              |.|..|...|::|.|
Mouse   627 NLLQATTVKTLPLVDSKDSMILLGSVERSELQSLLQRHLCAERRLKAAQDMARKLSELPYNGKAQ 691

  Fly   801 -------GISSSSIVL----------------------------------FTSSQPIQNLGPQP- 823
                   |....|...                                  ...|.|.:..||.|
Mouse   692 LAGDWHPGGRPESFAFVDEDEDEDLSRKMELPLTPAPPPPSPPPPPSQFPIAPSNPEEPNGPLPS 756

  Fly   824 ------------------------------LKLKKI----------------------------- 829
                                          .|.|||
Mouse   757 HKQPPEASDSADQRSSTFQRLLHCLLGKAHSKKKKITQDSTDLVDNMSPEEIEAWEREQLSQPVC 821

  Fly   830 -----LDMAPITVTDQTPMETVVDMFRKLGLRQTLVTHNGRLLGVITKKDVLRHVK 880
                 :|.:|..:.:||.:.....:|..|||....||..|:|.||:..:::.:.::
Mouse   822 FDCCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIE 877

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ClC-c	NP_001261922.1	ClC_3_like	215..719	CDD:239656	163/543 (30%)
		Voltage_CLC	298..699	CDD:279048	145/439 (33%)
		CBS	738..876	CDD:223591	45/271 (17%)
		CBS_pair_EriC_assoc_euk_bac	741..878	CDD:239964	45/270 (17%)
Clcn1	NP_038519.1	ClC_1_like	117..592	CDD:239655	166/553 (30%)
		Voltage_CLC	170..571	CDD:279048	145/439 (33%)
		Selectivity filter part_1. /evidence=ECO:0000250	188..192		3/3 (100%)
		Selectivity filter part_2. /evidence=ECO:0000250	230..234		3/3 (100%)
		Selectivity filter part_3. /evidence=ECO:0000250	482..486		2/3 (67%)
		CBS_pair	610..>665	CDD:301603	14/54 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	710..770		5/59 (8%)
		CBS_pair_EriC_assoc_euk_bac	<827..875	CDD:239964	14/47 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..954
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	971..994
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0038
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740